A5100418891- Stroke Rehabilitation and Recovery
- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Shoulder Injury and Treatment
- Exercise and Physiological Responses
- Diabetic Foot Ulcer Assessment and Management
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Oral and Maxillofacial Pathology
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Electromagnetic wave absorption materials
- Cardiovascular Health and Disease Prevention
- Music Therapy and Health
- High Altitude and Hypoxia
- Musculoskeletal Disorders and Rehabilitation
- Vestibular and auditory disorders
- Muscle activation and electromyography studies
- Virtual Reality Applications and Impacts
- Aldose Reductase and Taurine
Fudan University
2009-2025
Huashan Hospital
2009-2025
Sichuan University
2023-2024
Capital Medical University
2023-2024
Affiliated Hospital of North Sichuan Medical College
2020-2024
Nanjing Medical University
2020-2024
Nanjing Brain Hospital
2024
West China Hospital of Sichuan University
2023
Binzhou University
2022
Binzhou Medical University
2022
Neuronal pyroptosis and neuroinflammation with excess microglial activation are widely involved in the early pathological process of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive neuromodulatory technique, has recently been reported to be anti-inflammatory regulate function. However, few studies have elucidated role mechanism rTMS underlying regulating neuronal polarization.We evaluated motor function middle cerebral artery occlusion/reperfusion...
Background Motor imagery therapy (MIT) showed positive effects on upper limbs motor function. However, the mechanism by which MIT improves limb function is not fully understood. Therefore, our purpose was to investigate changes in functional connectivity (FC) within and outside sensorimotor network (SMN) induced associated with improvement stroke patients. Methods A total of 26 hemiplegic patients were randomly divided into ( n = 13) control groups. Fugl-Meyer Assessment Upper Extremity...
Background Stroke is the main disease that causes burden of neurological disease, leading to upper limb dysfunction and affecting their self-care abilities. Robot-assisted rehabilitation therapy has been gradually used in function after stroke. However, it would be beneficial explore auxiliary interventions such as reminiscent music therapy, a combination reminiscent, relieve negative emotions post-stroke fatigue improve outcomes. This protocol aims evaluate effectiveness combined with...
Abstract The neurovascular unit plays a critical role in maintaining brain structure, function, and homeostasis. Following ischemic stroke, dysfunction dysregulation of this contribute to nerve–blood vessel uncoupling. Intermittent theta-burst stimulation is repetitive transcranial magnetic that operates within the theta wave range can either promote or inhibit cortical excitability. Previous studies have shown intermittent has neuroprotective effects, but underlying mechanisms remain...
Abstract Background Although some studies suggest that robot-assisted technology can significantly improve upper limb function in stroke patients compared to traditional rehabilitation training, it is still necessary incorporate an auxiliary intervention alleviate negative emotions, thereby alleviating the post-stroke fatigue and encouraging actively respond rehabilitation. However, effect of unknown. Objective To evaluate reminiscent music therapy combined with elderly dysfunction. Methods...
Repetitive TMS has been used as an alternative treatment for various neurological disorders. However, most mechanism studies in rodents have based on the whole brain stimulation, lack of rodent-specific focal coils restricts proper translation human protocols to animal models. In this study, we designed a new shielding device, which was made high magnetic permeability material, enhance spatial focus animal-use coils. With finite element method, analyzed electromagnetic field coil with and...
Although skeletal muscle is the main effector organ largely accounting for disability after stroke, considerably less attention paid to secondary abnormalities of stroke-related loss. It necessary explore mechanism atrophy stroke and further develop effective rehabilitation strategy. Here, we evaluated effects high-intensity interval (HIIT) versus moderate-intensity aerobic training (MOD) on physical function, mass, gene expression profile muscle. After model middle cerebral artery occlusion...
Abstract Elderly individuals with non-dipper hypertension are at high risk of cardiovascular disease because increased stiffness peripheral arteries. Since, vitamin D deficiency is prevalent in elderly Chinese. We examined whether reduced plasma levels 25-hydroxyvitamin [25(OH)D] may help promote this stiffness. Hypertensive patients least 60 years old without history arterial our hospital were retrospectively divided into dipper and groups according to the results 24-hour ambulatory blood...
An enriched environment (EE) has been demonstrated to improve functional recovery in animal models of ischaemic stroke through enhancing vascular endothelial growth factor- (VEGF-) mediated neuroprotection accompanied by angiogenesis the hemisphere. Whether EEs also promote VEGF-mediated and contralateral hemisphere remains unclear. Here, we explored effect on VEGF expression within cerebral cortex a rat middle artery occlusion/reperfusion (MCAO/r) model. We assessed levels platelet cell...
Abstract Neurovascular decoupling plays a significant role in dysfunction following an ischemic stroke. This study aimed to explore the effect of low- and high-frequency repetitive transcranial magnetic stimulation on neurovascular remodeling after To achieve this goal, we compared functional hyperemia, cerebral blood flow regulatory factors, neurochemical transmitters peri-infract cortex 21 days photothrombotic Our findings revealed that increased real-time healthy mice improved...
Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is an effective therapy in post‐stroke motor recovery. However, the underlying mechanisms of rTMS regulates long‐lasting changes with synaptic transmission and glutamate receptors function (including AMPARs or NMDARs) remains unclear. Methods Mice were received 10‐Hz treatment once daily on third day after photothrombotic (PT) stroke for 18 days. Motor behaviors Western blot used to evaluate therapeutic efficacy mice PT...
Skeletal muscle atrophy is one of the major side effects high dose or sustained usage glucocorticoids. Pyroptosis a novel form pro-inflammatory programmed cell death that may contribute to skeletal injury. Trimetazidine, well-known anti-anginal agent, can also improve performance both in human and mice. We here showed dexamethasone induced atrophy, evidenced by increase F-box (Atrogin-1) ring finger 1 (MuRF1) expression , decrease myotube diameter C2C12 myotubes. Dexamethasone pyroptosis,...
Wound infection, especially chronic ones, not only increases the opportunity to generate superbacteria but also imposes significant burden, both physically and mentally, on patients. Therefore, development of suitable wound addressing is an important way deal with this matter. Here in study, we employed good gelling property agarose (AR) healing promotion effect hyaluronic acid (HA) prepare agarose-hyaluronic hydrogel. The AR-HA gel was loaded silver ion (Ag + from AgNO 3 ) upon (AR-HA/Ag)...
In recent years, emergence of telerehabilitation systems for home-based therapy has altered healthcare systems. Telerehabilitation enables therapists to observe patients status via Internet, thus a patient does not have visit rehabilitation facilities every session. Despite the fact that provides great opportunities, there are two major issues affect effectiveness telerehabilitation: relegation at home, and loss direct supervision therapist. Since no actual interaction with other persons...
Objective To determine the correlation between family functioning and depression in primary care givers of community-dwelling stroke patients. Methods Totally 200 caregivers patients were investigated using Family Assessment Device (FAD) Center for Epidemiologic Studies Depression Scale (CES-D). Results The mean score was 2.21±0.38. The 10.19±3.17. Correlation analysis revealed a negative (r=-0.551, P < 0.01). Conclusions It is suggested to take actions enhance patients,...