A5074273728- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Nitric Oxide and Endothelin Effects
- Lymphoma Diagnosis and Treatment
- Inflammasome and immune disorders
- Uterine Myomas and Treatments
- Neural dynamics and brain function
- Balance, Gait, and Falls Prevention
- Lung Cancer Treatments and Mutations
- Ion channel regulation and function
- Cancer-related molecular mechanisms research
- Quinazolinone synthesis and applications
- Endometriosis Research and Treatment
- Obstructive Sleep Apnea Research
- Nerve injury and regeneration
- Diabetic Foot Ulcer Assessment and Management
- Inflammatory mediators and NSAID effects
- Wound Healing and Treatments
- Renin-Angiotensin System Studies
- Fibroblast Growth Factor Research
- Cardiac electrophysiology and arrhythmias
- Protease and Inhibitor Mechanisms
- Neurogenesis and neuroplasticity mechanisms
Fudan University
2012-2025
Huashan Hospital
2020-2025
Soochow University
2023
The First People's Hospital of Changzhou
2023
Air Force Medical University
2009-2019
Xijing Hospital
2009-2019
Qingdao University
2018-2019
Hunan Provincial People's Hospital
2019
Wenzhou Medical University
2017-2018
Nanjing Medical University
2017-2018
Neuronal pyroptosis and neuroinflammation with excess microglial activation are widely involved in the early pathological process of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive neuromodulatory technique, has recently been reported to be anti-inflammatory regulate function. However, few studies have elucidated role mechanism rTMS underlying regulating neuronal polarization.We evaluated motor function middle cerebral artery occlusion/reperfusion...
// Luo Lu 1 , Yaoyu Chen and Yu Zhu Department of Hematology, The First Affiliated Hospital Nanjing Medical University, Jiangsu Province Hospital, 210029, China Correspondence to: Zhu, email: zhuyu@jsph.org.cn Keywords: PFKFB3, glycolysis, autophagy, solid tumors, hematologic malignancies Received: April 23, 2017 Accepted: July 12, Published: 24, ABSTRACT 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) are bifunctional enzymes which regulate the transformation between...
• PTEN, TLR4, NF-κB and NLRP3 are increased in the hippocampus of PSD mice. PTEN suppression downregulates mouse . Exercise ameliorates via PTEN/TLR4/NF-κB/NLRP3 signaling.
Purpose.: Hyperosmotic stress causes cell shrinkage, perturbs function, and damages DNA, resulting in cycle arrest apoptosis. In the present study, authors explore mechanism involving hyperosmotic stress-induced activation of c-Jun/AP-1 through a novel Plk3 pathway human corneal epithelial cells. Methods.: Human primary cells line were cultured serum-free keratinocyte medium DMEM/F12 containing 10% FBS 37°C incubator supplied with 5% CO2, respectively. Western blot analysis was used to...
Enriched environment (EE) can protect the brain against damages caused by an ischemic stroke; however, underlying mechanism remains elusive. Autophagy and mitochondria quality control are instrumental in pathogenesis of stroke. In this study, we investigated whether how autophagy contribute to protective effect EE acute phase cerebral ischemia-reperfusion injury.We exposed transient middle artery occlusion (tMCAO) mice or standard condition (SC) for 7 days then studied them neurological...
Stroke remains a leading cause of death and disability worldwide, electroacupuncture has long history use in stroke treatment. This meta-analysis systematic review aimed to evaluate the efficacy explore its potential mechanisms animal models ischemic stroke. The PubMed, EMBASE, Web Science, CENTRAL, CINAHL databases were comprehensively searched up May 1, 2024. included articles on preclinical investigations treating Data from 70 eligible studies analyzed Stata 18.0, using random-effects...
Abstract The neurovascular unit plays a critical role in maintaining brain structure, function, and homeostasis. Following ischemic stroke, dysfunction dysregulation of this contribute to nerve–blood vessel uncoupling. Intermittent theta-burst stimulation is repetitive transcranial magnetic that operates within the theta wave range can either promote or inhibit cortical excitability. Previous studies have shown intermittent has neuroprotective effects, but underlying mechanisms remain...
The exposure of mammalian cells to UV irradiation induces the expression immediate early genes such as c-jun and c-fos activates transcription factors AP-1 NF-κB. JunD is one three members Jun family shares some functional characteristics with c-Jun. In present study, we found that myeloblastic leukemia ML-1 light (UVC) caused a significant increase injunD mRNA within 5 min persisted for period 3 h. activation protein kinase C (PKC) 12-O-tetradecaoylphorbol-13-acetate (TPA) also induced...
We designed and synthesized 26 prototype compounds studied their anti-inflammatory activity underlying molecular mechanisms. The inhibitory effects of the on production nitric oxide (NO), cytokines, inflammatory-related proteins, mRNAs in lipopolysaccharide (LPS)-stimulated macrophages were determined by Griess assay, Enzyme linked immunosorbent assay (ELISA), Western blot analysis, Reverse transcription-Polymerase Chain Reaction (RT-PCR), respectively. Our results indicated that treatment...
gamma-Aminobutyric acid (GABA) receptor/channel rho 1 subunits are important components in inhibitory pathways the central nervous system. However, precise locations and roles of these receptors system unknown. We studied expression localization GABA subunit mouse spinal cord dorsal root ganglia (DRG). The immunohistochemistry results indicated that were expressed superficial horn (lamina I lamina II) DRG. To understand functions crucial sites sensory transmission vivo, we generated mutant...
purpose. The purpose of the present study is to determine role K+ channel activity as an early event in UV-induced corneal epithelial cell apoptosis. method. Both cell-attached and nystatin-perforated patch-clamping were performed record rabbit (RCE) primary cultured (PRCE) cells exposed UV irradiation. On exposure or intact corneas UV-C irradiation treatment with etoposide, apoptosis was determined by DNA fragmentation, ethidium bromide-acridine orange nuclear stain TdT-mediated dUTP...
Abstract Background Generalised recalcitrant facial verruca plana responds poorly to current therapeutic options, including cryotherapy, topical drugs and carbon dioxide (CO 2 ) laser. Case reports uncontrolled studies suggested that photodynamic therapy (PDT) is effective choice of treatment free from potential complications associated with invasive therapies. Aims To investigate the efficacy safety PDT different concentrations photosensitiser in plana. Materials & Methods The two sides...