A5100688090- Fungal Plant Pathogen Control
- Ovarian function and disorders
- Coal Properties and Utilization
- Hydrocarbon exploration and reservoir analysis
- Cancer, Hypoxia, and Metabolism
- Rock Mechanics and Modeling
- Spinal Cord Injury Research
- Plant Virus Research Studies
- Ionosphere and magnetosphere dynamics
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Plant-Microbe Interactions and Immunity
- Solar and Space Plasma Dynamics
- Geoscience and Mining Technology
- Geological Modeling and Analysis
- Reproductive Biology and Fertility
- Neurological Disease Mechanisms and Treatments
- Geomechanics and Mining Engineering
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and disorders
- Mitochondrial Function and Pathology
- Hormonal Regulation and Hypertension
- Congenital Heart Disease Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Shanghai Jiao Tong University
2025
Shanghai First People's Hospital
2025
Guizhou University
2007-2024
Nanjing Medical University
2007-2024
Guangzhou University of Chinese Medicine
2020-2024
Beijing Tsinghua Chang Gung Hospital
2024
Tsinghua University
2024
Nanjing General Hospital of Nanjing Military Command
2021-2024
Nanjing University
2021-2024
Southeast University
2024
Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the of complete SCI patients was still huge challenge clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as SCI. Here, two patients, with at thoracic 11 (T11) cervical 4 (C4) level respectively, were judged by stricter method combined American Spinal Injury Association (ASIA) Impairment...
Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin polycystic ovary syndrome (PCOS), disease partly characterized by resistance, and its potential connection type 2 diabetes mellitus (T2DM) PCOS has not been thoroughly elucidated to date. To investigate association metabolic profiles, sex-related hormones, or inflammation females T2DM PCOS, plasma indicators were measured 66 healthy females, 53 female...
The objective of this clinical study was to assess the safety and feasibility collagen scaffold, NeuroRegen one year after scar tissue resection implantation. Scar is a physical chemical barrier that prevents neural regeneration. However, identification still major challenge. In study, nerve electrophysiology method used distinguish from normal tissue, then different lengths scars ranging 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury (SCI) patients. scaffold...
In this study, 24 indole derivatives containing 1,3,4-thiadiazole were discovered and synthesized. The target compounds' antifungal efficacy against 14 plant pathogenic fungal pathogens was then determined in vitro. With an EC50 value of 2.7 μg/mL, Z2 demonstrated the highest level bioactivity among them Botrytis cinerea (B.c.), exceeding concentrations control prescription drugs azoxystrobin (Az) (EC50 = 14.5 μg/mL) fluopyram (Fl) 10.1 μg/mL). underwent vivo testing on blueberry leaves...
Patients with diabetes often experience multiple disease complications. Hypoglycemic agents can have both positive and negative effects on diabetic complications, which should be carefully assessed when personalized treatment strategies are developed. In this study we report that dipeptidyl peptidase 4 inhibitors (DPP-4is), a group of widely used antihyperglycemic agents, improve wound healing, independent their beneficial glycemic control. particular, DPP-4is promoted the migration...
BackgroundIncreasing evidence indicates that the gut microbiota contributes to occurrence and development of metabolic diseases. However, little is known about effects commonly used antidiabetic agents on microbiota. In this study, we investigated roles dipeptidyl peptidase-4 inhibitors (DPP-4i) α-glucosidase inhibitor in modulating microbiota.Methods16S-rDNA sequencing was performed analyse DPP-4i acarbose mice fed a high-fat diet (HFD). Fecal transplantation (FMT) from type 2 diabetes...
Abstract We present in situ observation of double layer (DL) and associated electron measurement the subspin time resolution separatrix region during reconnection for first time. The DL is inferred to propagate away from X line at a velocity about ion acoustic speed parallel electric field carried by can reach −20 mV/m. displays beam distribution inside streams toward with local Alfvén velocity. A series holes moving are observed wake DL. identification multiple similar DLs indicates that...
A series of myricetin derivatives containing amide and hydrazide were designed synthesized. All the compounds characterized by NMR HRMS. Bioactivity test showed that some target had excellent anti-tobacco mosaic virus (TMV) activity. In particular, median effective concentration (EC50) values anti-TMV curative protective activities N-(2-(2-(2-((5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromen-3-yl)oxy)acetyl)hydrazineyl)-2-oxoethyl)-4-(trifluoromethyl)benzamide (G9) 202.3 164.0...
A series of myricetin derivatives containing isoxazole were designed and synthesized. All the synthesized compounds characterized by NMR HRMS. In terms antifungal activity, Y3 had a good inhibitory effect on Sclerotinia sclerotiorum (Ss), median effective concentration (EC50) value was 13.24 μg mL-1, which better than azoxystrobin (23.04 mL-1) kresoxim-methyl (46.35 mL-1). Release cellular contents cell membrane permeability experiments further revealed that causes destruction hyphae, in...
Cancer remains a leading global cause of mortality, making early detection crucial for improving survival outcomes. The study aims to develop machine learning-enabled blood-derived exosomal RNA profiling platform multi-cancer and localization. In this multi-phase, multi-center study, we analyzed from exosomes derived peripheral blood plasma in 818 participants across eight cancer types during the discovery phase. Machine learning techniques were applied identify potential pan-cancer...
Abstract Background In recent years, immunotherapy has made significant progress. However, the understanding of heterogeneity and function T cells, particularly CD8 + in cervical cancer (CESC) microenvironment remains insufficient. We aim to characterize heterogeneity, developmental trajectory, regulatory network, intercellular communication cells squamous cell carcinoma construct a prognostic risk model based on transcriptomic characteristics cells. Methods integrated single-cell RNA...
Numerous studies have focused on the development of novel and innovative approaches for treatment peripheral nerve injury using artificial guide conduits. In this study, we attempted to bridge 3.5-cm defects sciatic with a longitudinally oriented collagen conduit (LOCC) loaded human umbilical cord mesenchymal stem cells (hUC-MSCs). The LOCC contains bundle aligned collagenous fibres enclosed in hollow tube. Our previous showed that an combined neurotrophic factors enhances regeneration....
Abstract Background Myocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, efficacy for MI treatment remains unsatisfactory. Therefore, it urgent to develop a novel therapeutic strategy. Methods Left anterior descending arteries (LAD) mice were ligated induce MI. Another set intravenously injected with PTEN inhibitor BPV (1 mg/kg) 1 h after LAD ligation and continued receive injection daily following 6 days. Mice performed echocardiography 14...
A series of chalcone derivatives containing indanone were designed and synthesized by aldehyde-ketone condensation etherification. The activity test demonstrated that the majority compounds had good therapeutic protective activities against tobacco mosaic virus (TMV) at a concentration 500 μg/mL when being tested. Among them, target N2 N7 showed TMV with EC50 values 70.7 89.9 μg/mL, respectively, which better than ningnanmycin (158.3 μg/mL). N10 60.8 120.3 superior to (175.6 hydrogen bond...
A series of myricetin derivatives containing phenoxypyridine structure were designed and synthesized on the basis natural product myricitrin, which structurally characterized NMR HRMS. The results antiviral activity tests showed that some target compounds exhibited better inhibitory effects. Among them, B19 B21 curative with EC50 values 195.67 173.64 μg/mL, respectively, superior to control agent ningnanmycin(NNM) (238.30 μg/mL). protective value 236.37 was than NNM (269.89 microcalorimetry...