A5003355573- Nerve injury and regeneration
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell death mechanisms and regulation
- Nerve Injury and Rehabilitation
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Thermal Regulation in Medicine
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Mesenchymal stem cell research
- Ion Transport and Channel Regulation
- 14-3-3 protein interactions
- FOXO transcription factor regulation
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Graphene and Nanomaterials Applications
- Autophagy in Disease and Therapy
- Anesthesia and Neurotoxicity Research
- Advanced Glycation End Products research
- Mechanisms of cancer metastasis
- Sirtuins and Resveratrol in Medicine
Tianjin Economic-Technological Development Area
2023-2024
Nanchang Hangkong University
2022
Logistics University of People's Armed Police Force
2013-2021
Chinese People's Armed Police Force
2006-2021
Pingjin Hospital
2012-2017
Tianjin University of Traditional Chinese Medicine
2015
Chinese People's Armed Police Force Medical College Affiliated Hospital
2006-2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2010
Regeneration of damaged neurons and recovery sensation motor function after complete spinal cord injury (SCI) are challenging. We previously developed a collagen scaffold, NeuroRegen, to promote axonal growth along fibers inhibit glial scar formation SCI. When functionalized with multiple biomolecules, this scaffold promoted neurological regeneration functional in animals In study, eight patients chronic SCI were enrolled examine the safety efficacy implanting NeuroRegen human umbilical...
Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the of complete SCI patients was still huge challenge clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as SCI. Here, two patients, with at thoracic 11 (T11) cervical 4 (C4) level respectively, were judged by stricter method combined American Spinal Injury Association (ASIA) Impairment...
The objective of this clinical study was to assess the safety and feasibility collagen scaffold, NeuroRegen one year after scar tissue resection implantation. Scar is a physical chemical barrier that prevents neural regeneration. However, identification still major challenge. In study, nerve electrophysiology method used distinguish from normal tissue, then different lengths scars ranging 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury (SCI) patients. scaffold...
Necroptosis, a novel type of programmed cell death, is involved in stroke-induced ischemic brain injury. Although studies have sought to explore the mechanisms necroptosis, its signaling pathway has not yet be completely elucidated. Thus, we used oxygen-glucose deprivation (OGD) and middle cerebral artery occlusion (MCAO) models mimicking stroke (IS) conditions investigate necroptosis. We found that OGD MCAO induced local ischemia neurological deficit, while zVAD-fmk (zVAD, an apoptotic...
Traumatic spinal cord injury (SCI) causes neuronal death, demyelination, axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in interruption of neural signaling loss nerve function. Multifactorial targeted therapy is a promising strategy for SCI.The anti-inflammatory peptide KAFAKLAARLYRKALARQLGVAA (KAFAK) brain-derived neurotrophic factor (BDNF)-modified hyaluronan-methylcellulose (HAMC) hydrogel was designed minimally invasive, localized, sustained...
The intricate electrophysiological functions and anatomical structures of spinal cord tissue render the establishment in vitro models for cord-related diseases highly challenging. Currently, both vivo are still underdeveloped, complicating exploration development effective therapeutic drugs or strategies. Organoids cultured from human induced pluripotent stem cells (hiPSCs) hold promise as suitable diseases. However, cultivation organoids predominantly relies on Matrigel, a matrix derived...
Background Forkhead box Q1 (FoxQ1) is a member of the forkhead transcription factor family, and it has recently been found to participate in cancer development. However, whether FoxQ1 expression contributes glioma development progression not known. We investigate gliomas role during tumorgenesis. Methods Reverse quantitative real-time PCR (RT-qPCR) Western blot were used determine Neurexins 3 (NRXN3) gliomas. Chromatin immunoprecipitation (ChIP) luciferase assays regulation between NRXN3....
Neuroblastoma is a common childhood tumor. Vincristine (VCR), an alkaloid extracted from Catharanthus roseus, commonly used in combination chemotherapy. However, the mechanisms of VCR-induced neuroblastoma cell death are not clear. The aim this study was to investigate impact VCR on mitosis and apoptosis SH-SY5Y cells underlying mechanisms. were treated with increasing doses for different time points. Cell proliferation detected using MTT assay. Mitotic rate quantified by immunofluorescence....
Forkhead box M1 (FoxM1) is a member of the forkhead transcription factor family and overexpression in malignant gliomas. However, molecular mechanisms by which FoxM1lead to glioma carcinogenesis progression are still not well known. In present study, we show that Anxa1 was gliomas predicted poor outcome. Furthermore, closely related FoxM1 expression direct transcriptional target FoxM1. Overexpression up-regulated expression, whereas suppression down-regulated cells. Finally, enhanced...
Glioma is one of the most malignant forms brain tumor, and has been persistent concern due to its high recurrence mortality rates, limited therapeutic options. As a cardiac glycoside, ouabain widespread applications in congestive heart diseases positive inotropic effect by inhibiting Na+/K+‑ATPase. Previous studies have demonstrated that antitumor activity several types human including glioma. However, exact underlying mechanism remains be elucidated. The purpose present study was elucidate...
Many studies have shown the Na+/K+-ATPase (NKA) might be a potential target for anticancer therapy. Cardiac glycosides (CGs), as family of naturally compounds, inhibited NKA activity. The present study investigates antitumor effect ouabain and elucidates pharmacological mechanisms CG activity in liver cancer HepG2 cell using SILAC coupled to LC–MS/MS method. Bioinformatics analysis 330 proteins that were changed cells under treatment with 0.5 μmol/L showed biological processes are associated...
To analyze and compare the difference prognosis between vascular embolization craniotomy occlusion in patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) with Hunt-Hess level III-IV, acute postoperative hydrocephalus.A retrospective study was conducted on 767 who had undergone (vascular group, n = 403) or operation (craniotomy 364), hydrocephalus were screened. The clinical data of both groups analyzed. By judging short-term Glasgow outcome scale (GOS) score estimated at...
Objective To explore the association between glycogen synthase kinase-3β (GSK-3β) rs334558 gene polymorphism and major depressive disorder (MDD) in Han Chinese. Methods Genotypes alleles frequency of GSK-3β were examined 250 patients 300 healthy controls by method polymerase chain reaction-restriction fragment length (PCR-RFLP). SPSS 17.0 statistical software was used for analysis. Results (1) locus CC, CT+ TT genotypes distribution patient group (CC, genotypes: 38.4%, 61.6%.C,...