A5100372311- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Ion channel regulation and function
- Spinal Cord Injury Research
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Neuroscience and Neuropharmacology Research
- Renal and related cancers
University of Macau
2025
Guangdong Polytechnic of Science and Technology
2022-2025
Chinese Academy of Sciences
2011-2024
Binzhou University
2014-2024
Cangzhou Central Hospital
2019-2024
ZheJiang Academy of Agricultural Sciences
2022-2024
Ministry of Agriculture and Rural Affairs
2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Second Affiliated Hospital of Jilin University
2024
Xiangnan University
2022-2024
Abstract More than 90% of clear cell renal carcinomas (ccRCC) exhibit inactivation the von Hippel–Lindau (pVHL) tumor suppressor, establishing it as major underlying cause this malignancy. pVHL results in stabilization hypoxia-inducible transcription factors, HIF1α and HIF2α, leading to expression a genetic program essential for initiation progression ccRCC. Herein, we describe potent, selective, orally active small-molecule inhibitor PT2385 specific antagonist HIF2α that allosterically...
Abstract The lower reach of the Yangtze River basin (LYRB) is located at central region mei-yu and baiu front, which represents subtropical East Asian (EA) summer monsoon. Based on newly released daily rainfall data, two dominant intraseasonal variation (ISV) modes are identified over LYRB during boreal (May–August), with spectral peaks occurring day 15 (the biweekly mode) 24 21–30-day mode). These have comparable intensities, together they account for above about 57% total variance. Both...
The excessive accumulation of soluble amyloid peptides (Aβ) plays a crucial role in the pathogenesis Alzheimer's disease (AD), particularly synaptic dysfunction. two major chaperone proteins, Hsp70 and Hsp90, clearing misfolded protein aggregates has been established. Despite their abundant presence synapses, these chaperones synapses remains elusive. Here, we report that Hsp90 inhibition by 17-AAG elicited not only heat shock-like response but also upregulated presynaptic postsynaptic such...
Initiation of cocaine self-administration in rats was associated with release glutamate the ventral tegmental area (VTA). The transient, despite continued intake. Similar seen earning, for first time, unexpected saline rather than expected cocaine. VTA not similarly trained earning instead 13th time. also that received yoked earned injections on test day. a group had never but during training period. Glutamate no previous experience GABA levels did fluctuate any aspect seeking. Blockade...
Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise control mRNA requires investigation. We report that Fmr1-encoded protein, FMRP-mediated axonal delivery miR-181d negatively regulates elongation by locally transcripts MAP1B (Map1b) calmodulin (Calm1) in primary sensory neurons. affected synthesis axons. FMRP was associated with miR-181d, Map1b, Calm1. Both deficiency Fmr1(I304N) mice Fmr1 knockdown impeded Calm1 reduced protein...
In Aspergillus nidulans, the nitrogen metabolite repression regulator NmrA plays a major role in regulating activity of GATA transcription factor AreA during metabolism. However, function nmrA flavus has not been previously studied. Here, we report identification and functional analysis A. flavus. Our work showed that amino acid sequences are highly conserved among species protein contains canonical Rossmann fold motif. Deletion slowed growth but significantly increased conidiation sclerotia...
Abstract Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding mutational landscape this subtype in Chinese patients is currently limited. We performed whole exome sequencing samples from 100 with SQCCs to search somatic mutations and the subsequent target capture another 98 validation. identified 20 significantly mutated genes, including TP53 , CDH10 NFE2L2 PTEN . Pathways frequently genes included those cell-cell adhesion/Wnt/Hippo 76%,...
Adipogenesis of bone marrow mesenchymal stem cells (MSCs) promotes chemoresistance acute myeloid leukaemia (AML) cells. MSCs from AML patients (AML-MSCs) display enhanced adipogenesis compared with healthy donors. However, the precise molecular mechanism by which differs normal counterparts remains obscure. We found that METTL3 significantly inhibits MSC adipogenesis. Here, we aimed to identify linking and Analysis m6 A epigenetic changes in determined via RIP-qPCR MeRIP-qPCR indicated...
Background: Hepatocellular carcinoma (HCC) is a primary aggressive gastrointestinal neoplasm that affects patients worldwide. It has been shown Wilms' tumor 1-associating protein (WTAP) frequently upregulated in various cancers. However, the potential role of WTAP HCC remains largely unknown. Methods: The expression levels human tissues were determined by western blotting and immunohistochemical (IHC) staining. A correlation between expression, clinicopathological features, prognosis was...
Nucleotide de novo synthesis is essential to cell growth and survival, its dysregulation leads cancers drug resistance. However, how this pathway dysregulated in cancer has not been well clarified. This study aimed identify the regulatory mechanisms of nucleotide resistance.By combining ChIP-Seq data from Cistrome Data Browser, RNA sequencing (RNA-Seq) a luciferase-based promoter assay, we identified transcription factor FOXK2 as regulator synthesis. To explore biological functions cancers,...
Over the South China Sea, year‐to‐year variations in intensity of quasi‐biweekly (QBW) and 30–50‐day oscillations during June–July are anti‐correlated. An explanation is offered for out‐of‐phase relationship. We found strong QBW years, mean convection easterly vertical shear enhanced over equatorial western‐central Pacific, with corresponding low‐level cyclonic meridional to northwest. These conditions, concurring eastern Pacific warming, favorable emanation moist Rossby waves from western...
Gene therapy holds tremendous potential for the treatment of incurable brain diseases including Alzheimer's disease (AD), stroke, glioma, and Parkinson's disease. The main challenge is lack effective gene delivery systems traversing blood-brain barrier (BBB), due to complex microvessels present in which restrict substances from circulating blood passing through. Recently, increasing efforts have been made develop promising carriers brain-related therapies. One such development self-assembled...
Triple-negative breast cancer (TNBC), the most aggressive subtype of cancer, always exhibits a poor prognosis due to high risk early recurrence and distant metastasis. Long noncoding RNAs (lncRNAs) have been reported as crucial regulators in cancer. However, functions action mechanisms lncRNA ST8SIA6-AS1 TNBC are largely unknown.Quantitative real-time PCR western blot assays were used measure expression levels different genes proteins. Cell proliferation ability was monitored by CCK-8,...