A5076887655- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- RNA regulation and disease
- Chromatography in Natural Products
- SARS-CoV-2 and COVID-19 Research
- Marine and coastal plant biology
- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological disorders and treatments
- HIV/AIDS drug development and treatment
Guangzhou University of Chinese Medicine
2019-2025
Shenzhen Pingle Orthopedic Hospital
2020-2024
Shanxi Medical University
2024
Shanxi Province Hospital of Traditional Chinese Medicine
2024
Ocean University of China
2021-2023
Innovation Research Center
2023
Xuzhou Medical College
2022
Nanjing Drum Tower Hospital
2014-2022
Anhui Medical University
2020-2022
Chinese Center For Disease Control and Prevention
2022
Abstract Mammalian target of rapamycin complex 1 (mTORC1) plays an important role in maintaining proper cellular functions, and genetic variations this may affect cancer risk. In study, we examined the associations between eight potential functional single nucleotide polymorphisms mTORC1 genes (rs2536T>C rs1883965G>A for mTOR , rs3160T>C, rs26865A>G mLST8 rs3751934C>A, rs1062935T>C, rs3751932T>C, rs12602885G>A Raptor not included published gastric genome‐wide...
The modification of methyltransferase-like (METTL) enzymes plays important roles in various cellular responses by regulating microRNA expression. However, how m6A is involved stress granule (SG) formation the early stage acute ischemic stroke affecting biogenesis processing microRNAs remains unclear. Here, we established a middle cerebral artery occlusion (MCAO) model rats and an oxygen-glucose deprivation/reperfusion (OGD/R) primary cortical neurons PC12 cells to explore potential mechanism...
Ferroptosis is a type of cell death induced by the iron-dependent accumulation lipid hydroperoxides and reactive oxygen species (ROS) in cells. Inhibiting ferroptosis important for improving survival transplanted bone marrow-derived mesenchymal stem cells (BMSCs). Although it known that NOP2/Sun RNA methyltransferase 5 (NSUN5) post-transcriptionally regulates BMSCs through methylation, precise mechanisms underlying these effects have not been reported. In this study, we demonstrate NSUN5...
Parkinson's disease (PD) is a neurodegenerative characterized by the selective loss of dopaminergic neurons in substantia nigra (SN). In previous study, authors demonstrated that ferritin heavy chain 1 (FTH1) inhibited ferroptosis model 6‑hydroxydopamine (6‑OHDA)‑induced PD. However, whether and how microRNAs (miRNAs/miRs) modulate FTH1 PD not yet well understood. present <em>in vivo</em> vitro</em> models induced 6‑OHDA were established. The results revealed levels marker protein,...
Objective Current evidence on the association between dietary vitamin E intake and risk of Parkinson's disease (PD) is limited. The aim study was to explore with PD in United States among adults over 40 years. Methods We conducted a cross-sectional data collected from National Health Nutrition Examination Survey (NHANES) 2009 2018. A total sample 13,340 participants were included. To identify different characteristics participants, we utilized propensity score matching (PSM) reduce effects...
The internal anal sphincter develops tone important for maintaining high pressure and continence. Controversy exists regarding the mechanisms underlying development. We examined hypothesis that depends upon electrical slow waves (SWs) initiated in intramuscular interstitial cells of Cajal (ICC-IM) by activation Ca2+ -activated Cl- channels (ANO1, encoded Ano1) voltage-dependent L-type (CavL , Cacna1c). Measurement membrane potential contraction indicated ANO1 CavL have a central role SW...
Abstract Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding mutational landscape this subtype in Chinese patients is currently limited. We performed whole exome sequencing samples from 100 with SQCCs to search somatic mutations and the subsequent target capture another 98 validation. identified 20 significantly mutated genes, including TP53 , CDH10 NFE2L2 PTEN . Pathways frequently genes included those cell-cell adhesion/Wnt/Hippo 76%,...
Seagrasses are marine flowering plants found in tropical and sub-tropical areas that live coastal regions between the sea land. All seagrass species evolved from terrestrial monocotyledons, providing opportunity to study plant adaptation environments. Here, we sequenced chloroplast genomes (cpGenomes) of three Zostera species, then analyzed compared their cpGenome structures sequence variations. We also performed a phylogenetic analysis using published chloroplasts calculated selection...
Seed development is a crucial phase in the life cycle of seed-propagated plants. As only group angiosperms that evolved from terrestrial plants to complete their submerged marine environments, mechanisms underlying seed seagrasses are still largely unknown. In present study, we attempted combine transcriptomic, metabolomic, and physiological data comprehensively analyze molecular mechanism regulates energy metabolism Zostera marina seeds at four major developmental stages. Our results...
Thyroid hormones (THs) are critical for metabolic regulation and brain development. Disruptions in TH homeostasis, especially during fetal development, can lead to irreversible neurodevelopmental impairments. hormone system-disrupting chemicals (THSDCs), of growing concern human health due their potential interfere with signaling. This study investigates the toxicokinetic properties two THSDCs: propylthiouracil (PTU), which inhibits synthesis, pregnenolone-16α‑carbonitrile (PCN), enhances...
Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in East Asian population. MicroRNAs (miRNAs) have been studied to play important roles tumorigenesis. Single nucleotide polymorphisms (SNPs) miRNA lead aberrant expression and structural alteration are hypothesized be involved tumorigenesis development. We conducted a population-based case-control study evaluate association between SNPs miRNAs ESCC risk 1400 cases 2185 matched controls. Four including...
Parkinson’s disease (PD) is a common neurodegenerative in the elderly, which related to brain iron metabolism disorders. Ferroptosis newly discovered iron-dependent programmed cell death mode, has been considered an essential mechanism of PD pathogenesis recent years. However, its underlying mechanisms have not fully understood. In present study, rat model and were induced by 6-hydroyxdopamine (6-OHDA). The results showed that expression Sorting Nexin 5 (SNX5) level ferroptosis will increase...
Purpose This study was conducted in order to properly understand whether prior seasonal human coronavirus (HCoV) immunity could impact the potential cross-reactivity of humoral responses induced by SARS-CoV-2 vaccine, thereby devising universal vaccines for future outbreaks. Methods We performed enzyme-linked immunosorbent assay (ELISA) quantify immunoglobulin G (IgG) antibody levels spike (S) protein and S1 subunit HCoVs (HCoV-OC43, HCoV-HKU1, HCoV-NL63, HCoV-229E), ELISA [anti-RBD...
Parkinson's disease dementia (PDD) is a common complication of that seriously affects patients' health and quality life. At present, the process pathological mechanisms PDD remain controversial, which hinders development treatments. An increasing number clinical studies have shown alpha-synuclein (α-syn), tau, beta-amyloid (Aβ), iron are closely associated with severity. Thus, we inferred vicious cycle causes oxidative stress (OS), due to synergistic effects α-syn, Aβ, and, iron, plays...
The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, olive oil, has anti-oxidative anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well the influence different factors on relationship between depression. Here, we investigated associations alternate (aMED) score...
The objective of this study was to explore the neuroprotective effect moxibustion on rats with Parkinson's disease (PD) and its mechanism. A model established in using a two-point stereotactic 6-hydroxydopamine injection right substantia nigra (SN) ventral tegmental area. received at Baihui (GV20) Sishencong (EX-HN1) acupoints for 20 minutes, six times week, 6 weeks. SN tissue histologically immunohistochemically examined. Differentially expressed genes (DEGs) were identified through RNA...