A5100784066- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Urinary and Genital Oncology Studies
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- Renal cell carcinoma treatment
- 14-3-3 protein interactions
- Urological Disorders and Treatments
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Ureteral procedures and complications
- Cancer Immunotherapy and Biomarkers
- Endometriosis Research and Treatment
- Peptidase Inhibition and Analysis
- Pelvic and Acetabular Injuries
- Cancer-related molecular mechanisms research
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Pregnancy-related medical research
- Ovarian cancer diagnosis and treatment
- Renal and Vascular Pathologies
- HER2/EGFR in Cancer Research
- Mesenchymal stem cell research
- Anorectal Disease Treatments and Outcomes
Union Hospital
2011-2025
Huazhong University of Science and Technology
2011-2025
Air Force Medical University
2011-2025
Shanghai Changzheng Hospital
2021-2024
Second Hospital of Anhui Medical University
2012-2024
Anhui Medical University
2012-2024
First People's Hospital of Chongqing
2015-2024
Southwest Medical University
2024
Osaka Dental University
2024
Nanjing University of Chinese Medicine
2022-2023
While there has been significant progress in determining the transcriptional cascade involved terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It recently discovered that zinc finger protein 423 (Zfp423) an actor adipose determination. Here, we show a close paralog of Zfp423, Zfp521, acts as key regulator differentiation vitro vivo. Zfp521 exerts its actions by binding B factor 1 (Ebf1), transcription required for...
Treatment strategy for hepatocellular carcinoma (HCC) and Vp4 [main trunk] portal vein tumor thrombosis (PVTT) remains limited due to posttreatment liver failure. We aimed assess the efficacy of irradiation stent placement with 125 I plus transcatheter arterial chemoembolization (TACE) (ISP-TACE) compared sorafenib TACE (Sora-TACE) in these patients.In this multicenter randomized controlled trial, participants HCC PVTT without extrahepatic metastases were enrolled from November 2018 July...
The aim of the present study was to explore underlying mechanisms roles mechanical factors in pathogenesis pelvic organ prolapse (POP). experiments were performed on fibroblasts derived from uterosacral ligaments and cardinal patients who received total hysterectomy due benign disease excluding POP. Fibroblasts cultured after collagenase digestion identified by morphological observation immunocytochemical methods. A four‑point bending device used subject at passage 4‑6 strains 0, 1,333 µ (1...
Endometrial cancer (EC) is commonly diagnosed in women, and the prognosis of advanced types EC extremely poor. Kinesin family member 2C (KIF2C) has been reported as an oncogene cancers. However, its pathophysiological roles correlation with tumor-infiltrating lymphocytes remain unclear. The mRNA protein levels KIF2C tissues were detected by qRT-PCR, Western blot (WB), IHC. CCK8, Transwell, colony formation assay applied to assess effects on cell proliferation, migration, invasion. Cell...
Radiation therapy (RT) remains the primary treatment modality for advanced cervical cancer, however, recurrence due to radioresistance presents a significant challenge. Cancer-associated fibroblasts (CAFs) within tumor microenvironment (TME) are key contributors this resistance, driven by their inherent and radiation-induced phenotypic adaptations. Addressing issue requires strategies specifically designed target CAFs enhance radiosensitivity. In study, we developed biomimetic metal–organic...
194 Background: Colorectal cancer (CRC) is increasingly prevalent in China, with rising incidence and mortality rates. Often, early-stage CRC presents no symptoms, leading to most patients being diagnosed at an advanced stage, where prognosis poor. First- second-line treatments for typically include chemotherapy combined cetuximab or bevacizumab. However, third-line therapies such as regorafenib, furosemide, TAS102 have shown limited efficacy. Anlotinib, a multi-targeted tyrosine kinase...
Abstract Objective The objective of this study was to assess the quality clinical practice guidelines providing diagnostic recommendations on pheochromocytoma ( PHEO ) using new Appraisal Guidelines for Research and Evaluation AGREE II instrument promote development guidelines. design methods We searched MEDLINE electronic databases published between 2001 2010 regarding diagnosis . methodological three fields evaluated by two independent appraisers. also compared different types determine...
To compare clinical outcomes in laparoscopic and open radical hysterectomy with pelvic lymphadenectomy (LRH) early cervical cancer without the selection bias.One special retrospective study was conducted more than 400 patients involved procedure.Our results suggest that estimated blood loss transfusion requirements were significantly lower LRH group. Postoperative hospital stay also shorter Significant difference found number of lymph nodes retrieved between (ORH) groups. There no...
Mechanical loading on pelvic supports contributes to organ prolapse (POP). However, the underlying mechanisms remain be elucidated. Our previous study identified that mechanical strain induced oxidative stress (OS) and promoted apoptosis senescence in support fibroblasts. The aim of present is investigate molecular signaling pathway linking force with POP. Using a four‑point bending device, human uterosacral ligament fibroblasts (hUSLF) were exposed tensile at frequency 0.3 Hz intensity 5333...
The present study aimed to reveal the metabolic alterations of extracellular matrix (ECM) in uterosacral ligament (USL) with pelvic organ prolapse (POP) and explore role transforming growth factor‑β1 (TGF‑β1) pathogenesis POP. For this purpse, 60 participants who underwent hysterectomy for benign indications were enrolled, 30 which had symptomatic POP (grade II, III or IV) composed group, other asymptomatic I less) served as controls. Collagen fibers, elastin,matrix metalloproteinase...
The regulation of the extracellular matrix (ECM) by mechanical stress is interest as ECM essential in development pelvic organ prolapse. In present study, effect overexposure to on ECM, and probable underlying mechanisms cultured human uterosacral ligament fibroblasts (hUSLFs), was explored. Mechanical has an oxidation‑antioxidation products parametrial fibroblasts. Thus, hUSLFs were incubated with different concentrations hydrogen peroxide elucidate any potential interactions. Excess H2O2...
Stress urinary incontinence (SUI) is a common hygienic problem affecting the quality of women's life worldwide. In this research, we revealed involvement and regulation extracellular matrix (ECM) remodeling, oxidative damage, TGF-β1 signaling in pathological mechanisms mechanical trauma-induced SUI. We found that excessive strain significantly increased apoptosis rate, decreased cell viability ECM production, broke balance MMPs/TIMPs compared with nonstrain control (NC) group. The expression...
Hepatocellular carcinoma (HCC) is the seventh most common malignancy and third leading cause of cancer-related death worldwide with an extremely grim prognosis. Berberine (BBR) has been found to inhibit proliferation human HCC cells, although underlying mechanism(s) are unclear.Protein expression was detected by Western blots. Cell viability determined using CellTiter Assay kit.We confirm that BBR treatment inhibits HepG2, Hep3B, SNU-182 cell viability, suggest it regulates this via...
Pancreatic cancer (PAC) is one of the most malignant types and immunotherapy has emerged as a promising treatment option. PAC cells undergo metabolic reprogramming, which thought to modulate tumor microenvironment (TME) affect outcomes. However, landscape its association with TME remains largely unexplored. We characterized based on 112 pathways constructed novel metabolism-related signature (MBS) using data from 1,188 patients PAC. evaluated predictive performance MBS for outcomes in 11...
Cigarette smoke has been shown to be a major risk factor for bladder cancer. Epithelial-mesenchymal transition (EMT) is crucial process in cancer development. The role of MAPK pathways regulating cigarette smoke-triggered urocystic EMT remains elucidated. Human normal urothelial cells and BALB/c mice were used as vitro vivo exposure models. Exposure human induced morphological change, enhanced migratory invasive capacities, reduced epithelial marker expression increased mesenchymal...
A mouse model was used to investigate the role of hyaluronidase, transmembrane protein 2 (TMEM2), on progression Graves' orbital (GO) disease. We established a GO through immunization with plasmid expressing thyroid stimulating hormone receptor. Orbital fibroblasts (OFs) were subsequently isolated from both and non-GO mice for comprehensive in vitro analyses. The expression TMEM2 assessed using qRT-PCR, Western blot immunohistochemistry vivo. Disease pathology evaluated by H&E staining...
Objective To investigate the efficacy and safety of a novel method hyperthermic intraperitoneal chemotherapy (HIPEC) as adjuvant therapy for stage-III gastric cancer.Methods Patients with cancer who underwent D2 radical gastrectomy were randomly assigned to HIPEC or control group four weeks after surgery. The was treated cisplatin (60 mg/m2) administered device on days 1 3 (30 mg/m2 each time), along oral S-1, 40–60 mg, twice daily, 14 days. intravenously plus S-1 (40–60 2/d days). primary...