A5091039728- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Fatty Acid Research and Health
- Aquaculture Nutrition and Growth
- Diet and metabolism studies
- Trypanosoma species research and implications
- Autophagy in Disease and Therapy
- Reproductive biology and impacts on aquatic species
- Physiological and biochemical adaptations
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pancreatic function and diabetes
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
Harvard University
2008-2025
Beth Israel Deaconess Medical Center
2020-2025
Howard Hughes Medical Institute
2022-2025
Dana-Farber Cancer Institute
2007-2024
Hadassah Medical Center
2021-2024
Broad Institute
2024
Weatherford College
2024
University of California, San Francisco
2012-2021
Broad Center
2015-2021
Diabetes Australia
2016-2018
The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity a major risk factor for metabolic disease in rodents humans, while expansion fat does not carry the same risks. Brown produces heat as defense against hypothermia obesity, appearance brown-like adipocytes within tissue depots associated with improved phenotypes. Thus, understanding differences cell biology function these different types may be critical to development new...
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising distinct developmental lineages: "classical" develop during the prenatal stage whereas "beige" or "brite" cells that reside in white (WAT) postnatal response chronic PPARγ agonists. Beige cells' inducible characteristics make them a promising therapeutic target for obesity treatment, however, relevance this cell...
Brown fat is a specialized tissue that can dissipate energy and counteract obesity through pattern of gene expression greatly increases mitochondrial content uncoupled respiration. PRDM16 zinc-finger protein controls brown determination by stimulating fat-selective expression, while suppressing the genes selective for white cells. To determine mechanisms regulating this switching programs, we purified native complexes from We show here transcriptional holocompex contains C-terminal-binding...