A5066500327- Peroxisome Proliferator-Activated Receptors
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Nuclear Receptors and Signaling
- Retinoids in leukemia and cellular processes
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Nicotinic Acetylcholine Receptors Study
- Marine Sponges and Natural Products
- Chemical Synthesis and Analysis
- Immune Response and Inflammation
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- IL-33, ST2, and ILC Pathways
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Microbial Natural Products and Biosynthesis
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
Scripps Research Institute
2016-2025
Scripps (United States)
2013-2025
The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
2023-2025
Scripps Institution of Oceanography
2013-2024
University of Florida
2023-2024
University of Plymouth
2024
Jupiter Medical Center
2023
Institute of Molecular Medicine
2020
Icahn School of Medicine at Mount Sinai
2018
Translational Research Institute
2010
Damage to the insular cortex can profoundly disrupt tobacco addiction in human smokers, reflected spontaneous cessation of habit and persistently decreased urge smoke. Little is known concerning neurobiological mechanisms through which insula may control maintenance habit. Emerging evidence suggests that hypocretin (orexin) transmission play an important role drug reinforcement processes, but its rewarding actions nicotine, considered key addictive component smoke, remains largely...
Significance Hypocretin (orexin) and dynorphin are neuromodulators that play an important role in regulating affect motivation. Orexin is critical for reward implicated drug seeking, whereas mediates negative mood depressive-like states. Considering these opposing effects, reports both peptides expressed the same neurons coreleased counterintuitive. Here, we demonstrate orexin coexpressed within synaptic vesicles this colocalization has a profound influence on reward, taking, impulsive-like...
Abstract Nuclear receptors (NRs) are thought to dynamically alternate between transcriptionally active and repressive conformations, which stabilized upon ligand binding. Most NR series exhibit limited bias, primarily consisting of agonists or neutral antagonists, but not inverse agonists—a limitation that restricts understanding the functional conformational ensemble. Here, we report a for peroxisome proliferator-activated receptor gamma (PPARγ) spans pharmacological spectrum from...
Nuclear receptors (NRs) are ligand-regulated transcription factors that display canonical domain structure with highly conserved DNA-binding and ligand-binding domains. The identification of the endogenous ligands for several remains elusive or is controversial, thus these classified as orphans. One such orphan receptor retinoic acid receptor-related γ (RORγ). An isoform RORγ, RORγt, has been shown to be essential expression Interleukin 17 (IL-17) differentiation Th17 cells. cells have...
The nuclear receptor peroxisome proliferator-activated gamma (PPARγ) is the master regulator of adipogenesis and pharmacological target thiazolidinedione (TZD) class insulin sensitizers. Activation PPARγ by TZDs promotes at expense osteoblast formation, contributing to their associated adverse effects on bone. Recently, we reported development antagonist SR1664, designed block obesity-induced phosphorylation serine 273 (S273) in absence classical agonism, derive insulin-sensitizing efficacy...
Abstract A subset of nuclear receptors (NRs) function as obligate heterodimers with retinoid X receptor (RXR), allowing integration ligand-dependent signals across the dimer interface via an unknown structural mechanism. Using magnetic resonance (NMR) spectroscopy, x-ray crystallography and hydrogen/deuterium exchange (HDX) mass spectrometry, here we show allosteric mechanism through which RXR co-operates a permissive partner, peroxisome proliferator-activated (PPAR)-γ, while rendered...
RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH17) cell development. However, cell-intrinsic mechanisms that negatively regulate TH17 development and autoimmunity remain poorly understood. Here, we demonstrate transcriptional repressor REV-ERBα exclusively expressed in cells, competes with their shared DNA consensus sequence, regulates via repression of genes traditionally characterized dependent, including Il17a. Deletion enhanced TH17-mediated...
Nuclear receptors (NRs) are thought to dynamically alternate between transcriptionally active and repressive conformations, which stabilized upon ligand binding. Most NR series exhibit limited bias, primarily consisting of agonists or neutral antagonists, but not inverse agonists-a limitation that restricts understanding the functional conformational ensemble. Here, we report a for peroxisome proliferator-activated receptor gamma (PPARγ) spans pharmacological spectrum from repression...
The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbα expression is induced 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for binding required receptor’s activity. therefore hypothesized REV-ERB ligands may play regulation detected increase intracellular levels adipogenesis correlated with induction aminolevulinic acid synthase 1 (Alas1)...