A5065258001- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Pharmacology and Obesity Treatment
- Neurotransmitter Receptor Influence on Behavior
- Eating Disorders and Behaviors
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Diabetes Management and Research
- Gastrointestinal motility and disorders
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University of Pennsylvania
2016-2025
California University of Pennsylvania
2021-2024
Oxford University Hospitals NHS Trust
2024
Sanford USD Medical Center
2021
University of South Dakota
2021
University at Buffalo, State University of New York
2018
Lonza (United States)
2018
Northwestern University
2014
University of Alabama at Birmingham
2011
Zero to Three
2011
Central glucagon-like-peptide-1 (GLP-1) receptor activation reduces food intake; however, brain nuclei and mechanism(s) mediating this effect remain poorly understood. Although central nervous system GLP-1 is produced almost exclusively in the nucleus of solitary tract hindbrain, receptors (GLP-1R) are expressed throughout brain, including mesolimbic reward (MRS), e.g. ventral tegmental area (VTA) accumbens (NAc). Here, we examine MRS as a potential site action for GLP-1-mediated control...
The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake body weight. mediating site(s) of action for the anorectic effects produced by peripheral administration these GLP-1R agonists are not known. Experiments addressed whether suppression after ip delivery liraglutide is mediated exclusively or also involves direct central nervous system (CNS) activation. Results showed that CNS [third intracerebroventricular (3rd ICV)] antagonist...
Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity diabetes. Patient compliance maximal efficacy of GLP-1 therapeutics are limited by adverse side effects, including nausea emesis. In three different species (i.e., mice, rats, musk shrews), we show that glucose-dependent insulinotropic polypeptide (GIPR) signaling blocks emesis attenuates illness behaviors elicited GLP-1R activation, while maintaining reduced food intake, loss,...
Exogenous activation of central nervous system glucagon-like peptide-1 (GLP-1) receptors (GLP-1Rs) reduces food intake. Experiments addressed whether endogenous GLP-1R activity is involved in the control normal feeding and examined which gastrointestinal satiation signals contribute to this control. Given that nucleus tractus solitarius (NTS) neurons are source GLP-1, caudal brainstem circuits mediate intake suppression triggered by exogenous hindbrain activation, these process vagal...
The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding, gastric emptying, and energetic responses involve vagal transmission central nervous system processing. Despite a lack studies aimed at determining which regions are critical for the GLP-1R response production, hypothalamic/forebrain processing is regarded as essential these effects. Here contribution caudal brainstem to control food intake, core temperature, heart rate, emptying generated by delivery...
Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for control of palatable food intake. Here, we tested whether intake-suppressive effects VTA GLP-1R are mediated by glutamatergic signaling within VTA. Intra-VTA injections agonist exendin-4 (Ex-4) reduced high-fat intake rats primarily reducing meal size; these were part via AMPA/kainate but not NMDA signaling. Additional behavioral data indicated that expressed specifically...
Objective Weight stigma is a chronic stressor that may increase cardiometabolic risk. Some individuals with obesity self‐stigmatize (i.e., weight bias internalization, WBI). No study to date has examined whether WBI associated metabolic syndrome. Methods Blood pressure, waist circumference, and fasting glucose, triglycerides, high‐density lipoprotein cholesterol were measured at baseline in 178 adults enrolled weight‐loss trial. Medication use for hypertension, dyslipidemia, prediabetes was...
Astrocytes are well established modulators of extracellular glutamate, but their direct influence on energy balance-relevant behaviors is largely understudied. As the anorectic effects glucagon-like peptide-1 receptor (GLP-1R) agonists partly mediated by central modulation glutamatergic signaling, we tested hypothesis that astrocytic GLP-1R signaling regulates balance in rats. Central or peripheral administration a fluorophore-labeled agonist, exendin-4, localizes within astrocytes and...
Glucagon-like peptide-1 receptor (GLP-1R) activation in the nucleus accumbens (NAc) core is pharmacologically and physiologically relevant for regulating palatable food intake. Here, we assess whether GLP-1R signaling NAc of rats modulates GABAergic medium spiny neurons (MSNs) through presynaptic-glutamatergic and/or presynaptic-dopaminergic to control feeding. First, ex vivo fast-scan cyclic voltammetry showed that agonist exendin-4 (Ex-4) does not alter dopamine release core. Instead,...
Increased motivation for highly rewarding food is a major contributing factor to obesity. Most of the literature focuses on mesolimbic nuclei as core reward behavior regulation. However, lateral hypothalamus (LH) also key reward-control locus in brain. Here we hypothesize that manipulating glucagon-like peptide-1 receptor (GLP-1R) activity selectively LH can profoundly affect behavior, ultimately leading Progressive ratio operant responding sucrose was examined male and female rats,...