A5083090389- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Biochemical Analysis and Sensing Techniques
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Child and Animal Learning Development
- Social Representations and Identity
- Diet and metabolism studies
- Mental Health Research Topics
- Treatment of Major Depression
- Hormonal Regulation and Hypertension
- Smoking Behavior and Cessation
- Nutrition, Genetics, and Disease
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Gambling Behavior and Treatments
University of North Carolina at Chapel Hill
2019-2023
University of North Carolina Health Care
2023
Yale University
2012-2021
University of Pennsylvania
2011-2013
Serotonin (5-hydroxytryptamine; 5-HT) coordinates behavioral responses to stress through a variety of presynaptic and postsynaptic receptors distributed across functionally diverse neuronal networks in the central nervous system. Efferent 5-HT projections from dorsal raphe nucleus (DRN) bed stria terminalis (BNST) are generally thought enhance anxiety aversive learning by activating 5-HT2C receptor (5-HT2CR) signaling BNST, although an opposing role for 5-HT1A has recently been suggested. In...
There is ample evidence from human and animal models that sleep contributes to the consolidation of newly learned information. The precise role for integrating information into interconnected memory representations less well understood. Building on prior findings following (as compared wakefulness) people are better able draw inferences across associations in a simple hierarchy, we ask how helps consolidate relationships more complex representational space. We taught 60 subjects spatial...
Abstract Individuals with alcohol use disorder exhibit compulsive habitual behaviors that are thought to be, in part, a consequence of chronic and persistent alcohol. The endocannabinoid system plays critical role habit learning ethanol self‐administration, but the this neuromodulatory expression seeking is unknown. Here, we investigated established habits using contingency degradation male C57BL/6 mice. We found administration novel diacyl glycerol lipase inhibitor DO34, which decreases...
Excessive alcohol use causes a great deal of harm and negative health outcomes. Corticotrophin releasing factor (CRF), stress-related neuropeptide, has been implicated in binge ethanol intake dependence. CRF containing neurons the bed nucleus stria terminalis (BNST
The compulsive, habitual behaviors that have been observed in individuals diagnosed with substance use disorders may be due to disruptions the neural circuits mediate goal-directed actions. endocannabinoid system has shown play a critical role habit learning, but of this neuromodulatory expression is unclear. Here, we investigated established actions using contingency degradation male C57BL/6 mice. We found administration transport inhibitor AM404 reduced responding for food and antagonism...
The serotonin 5HT
Abstract Emerging data indicate that endocannabinoid signaling is critical to the formation of habitual behavior. Previous work demonstrated antagonism cannabinoid receptor type 1 (CB1R) with AM251 during operant training impairs habit formation, but it not known if this behavioral effect specific disrupted ligands anandamide or 2‐arachidonoyl glycerol (2‐AG). Here, we used selective pharmacological compounds determine impact fatty acid amide hydrolase (FAAH) inhibition increase (and other n...
Abstract High-level alcohol consumption causes neuroplastic changes in the brain that lead to negative affective and somatic symptoms when is withdrawn, promoting relapse drinking. We have some understanding of these plastic defined circuits cell types, but unbiased approaches are needed explore broader patterns adaptations. Here, we employed whole-brain c-fos mapping network analysis assess how brain-wide neuronal activity altered during acute abstinence reaccess a well-characterized model...
More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, implicated behavioral molecular consequences of chronic use, making NMDAR a promising target for novel pharmacotherapeutics. Ethanol exposure upregulates Fyn, protein tyrosine kinase that indirectly modulates signaling by phosphorylating NR2B subunit. Src/Fyn inhibitor saracatinib (AZD0530) reduces ethanol self-administration enhances extinction...
Land, Benjamina; Narayanan, Nandakumarb; Liu, Rong-Jiana; Gianessi, Carola; Brayton, Catherinea; Grimaldi, Davida; Sarhan, Maysaa; Guarnieri, Douglasa; Karl, Deisserothb; Aghajanian, Georgea; DiLeone, Ralph Author Information