A5076016497- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Neuroscience and Neural Engineering
- Hormonal Regulation and Hypertension
- Advanced Sensor and Energy Harvesting Materials
- Neurotransmitter Receptor Influence on Behavior
- Gender Roles and Identity Studies
- Nicotinic Acetylcholine Receptors Study
- Opioid Use Disorder Treatment
- Stress Responses and Cortisol
- Advanced Memory and Neural Computing
- Pain Mechanisms and Treatments
- Molecular Communication and Nanonetworks
- Regulation of Appetite and Obesity
- Pharmacological Effects and Assays
- Pharmacological Receptor Mechanisms and Effects
- Genetics and Physical Performance
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Behavioral Health and Interventions
- Neuroscience and Neuropharmacology Research
University of North Carolina at Chapel Hill
2023-2024
University of North Carolina Health Care
2023-2024
Washington University in St. Louis
2017-2023
University of Health Sciences and Pharmacy
2019-2023
University of Missouri
2018-2019
Traditionally, electronics have been designed with static form factors to serve designated purposes. This approach has an optimal direction for maintaining the overall device performance and reliability targeted applications. However, capable of changing their shape, flexibility, stretchability will enable versatile accommodating systems more diverse Here, we report design concepts, materials, physics, manufacturing strategies that these reconfigurable electronic based on...
Abstract Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition bladder sensory afferents temporarily relieves pain. Here, we explored possibility optogenetic nociceptive could be used to modulate The light-activated inhibitory proton pump Archaerhodopsin (Arch) was expressed under control neuron-specific sodium channel ( sns ) gene selectively...
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are highly homologous yet distinct components of signal transduction pathways known to regulate cell survival function. Recent evidence indicates an isoform-specific role for ERK2 in pain processing peripheral sensitization. However, the function primary sensory neurons has not been directly tested. To dissect neurons, we used mice with Cre-loxP-mediated deletion Na<sub>v</sub>1.8<sup>+</sup> that predominantly nociceptors. We find...
Excessive alcohol use causes a great deal of harm and negative health outcomes. Corticotrophin releasing factor (CRF), stress-related neuropeptide, has been implicated in binge ethanol intake dependence. CRF containing neurons the bed nucleus stria terminalis (BNST
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, world-wide, alcohol misuse is the 7th leading cause of premature death1. Despite this, there are currently only 3 FDA approved pharmacological treatments for treatment AUDs in United States. The neurotensin (Nts) system has long been implicated modulating behaviors associated with misuse. Recently, a novel compound, SBI-553, that biases action Nts receptor 1 (NTSR1) activation, shown promise preclinical models...
Abstract The central nucleus of the amygdala is known to play key roles in alcohol use and affect. Neurotensin neurons have been shown regulate drinking male mice. However, little about which neurotransmitters released by these cells drive consumption or whether female Here we show that knockdown GABA release from neurotensin using a Nts- cre-dependent vGAT-shRNA-based AAV strategy reduces male, but not female, This manipulation did impact avoidance behavior, except fasted novelty-suppressed...
The endogenous opioid peptide systems are critical for analgesia, reward processing, and affect, but research on their release dynamics function has been challenging. Here, we have developed microimmunoelectrodes (MIEs) the electrochemical detection of peptides using square-wave voltammetry. Briefly, a voltage is applied to electrode cause oxidation tyrosine residue interest, which detected as current. To provide selectivity these voltammetric measurements, carbon fiber surface MIE coated...
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition bladder sensory afferents temporarily relieves pain. Here, we explored possibility optogenetic could be used to modulate Specifically, chose study role Na v 1.8 + before and after induction a mouse model The light-activated inhibitory proton pump Archaerhodopsin (Arch) was expressed under...