A5013647917- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Olfactory and Sensory Function Studies
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Biochemical effects in animals
- Genetic Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Epilepsy research and treatment
- Alcohol Consumption and Health Effects
- Functional Brain Connectivity Studies
- Pharmacological Effects and Toxicity Studies
- Biochemical Analysis and Sensing Techniques
- Substance Abuse Treatment and Outcomes
- Psychosomatic Disorders and Their Treatments
University of North Carolina at Chapel Hill
2016-2025
Center for Alcohol Studies
2006-2025
University of North Carolina Health Care
2024
RTI International
2021
Indiana University School of Medicine
2007-2016
Institute of Alcohol Studies
2014
Tusculum College
2014
Medical University of South Carolina
2009
Thomas Jefferson University
2009
Florey Institute of Neuroscience and Mental Health
2009
Background: Emerging evidence indicates that Group I metabotropic glutamate receptors (mGluR1 and mGluR5) differentially regulates ethanol self‐administration in several rodent behavioral models. The purpose of this work was to further characterize involvement mGluRs the reinforcing effects using a progressive ratio schedule reinforcement. Methods: Alcohol‐preferring (P) rats were trained self‐administer (15% v/v) versus water on concurrent reinforcement, mGluR antagonists evaluated...
Alcohol use disorders are a costly public health dilemma. Complicating this issue is the general lack of basic research assessing sex differences in many aspects alcohol seeking and taking behaviors. The current experiments sought to decrease gap our understanding by both male female Long-Evans rats parallel on self-administration, relapse-like behavior following abstinence extinction, motivation respond for standard solution quinine-adulterated solution. Here, we show that while males tend...
Inherited human aldehyde dehydrogenase 2 (ALDH-2) deficiency reduces the risk for alcoholism. Kudzu plants and extracts have been used 1,000 years in traditional Chinese medicine to treat contains daidzin, which inhibits ALDH-2 suppresses heavy drinking rodents. Decreased due inhibition is attributed aversive properties of acetaldehyde accumulated during alcohol consumption. However, daidzin can reduce some rodents without necessarily increasing acetaldehyde. Therefore, a selective inhibitor...
Continued alcohol use despite negative consequences is a defining feature of disorder (AUD). It remains poorly understood whether individual variability in drinking due to inherent differences or emerges after prolonged use. The goal the present study was rat model assess foot shock-punished self-administration prior and following vapor exposure male Wistar rats. After baseline operant established, rats underwent additional sessions which random, response-contingent shock punishment...
Abstract Rationale Xylazine, a sedative typically used in veterinary medicine, has been increasingly detected as an adulterant the unregulated opioid supply and present overdose deaths. Therefore, xylazine-adulterated fentanyl is growing public health concern. People who use drugs have reported that xylazine changes prolongs effects of Objectives We standard operant drug discrimination procedures to better understand how impacts discriminative stimulus/interoceptive fentanyl. Methods Male...
Relaxin-3/RXFP3 antagonism is a novel strategy for drug development to treat alcohol use disorder (AUD). We recently discovered the first-in-class RXFP3 negative allosteric modulators (NAMs), represented by RLX-33, which significantly reduced consumption in rats. In this study, we report design and synthesis of series diphenyl-1,2,4-oxadiazole analogues derived from RLX-33. Structure-activity relationship studies sites A B RLX-33 revealed that aromatic ring at site not required modulation...
The interoceptive effects of alcohol are major determinants addiction liability. Metabotropic glutamate (mGlu) receptors widely expressed in striatal circuits known to modulate drug-seeking. Given that the drugs can be important abuse liability, we hypothesized mGlu alcohol. Using drug discrimination learning, rats were trained discriminate (1 g/kg, i.g.) versus water. We found systemic antagonism metabotropic subtype 5 (mGlu5) [10 mg/kg 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 3...
Background: Neuroactive steroids modulate ethanol intake in several self‐administration models with variable effects. The purpose of this work was to examine the effects long‐acting synthetic GABAergic neurosteroid ganaxolone and endogenous pregnenolone, a precursor all neuroactive steroids, on maintenance an animal model elevated drinking—the alcohol‐preferring (P) rats. Methods: P rats were trained self‐administer (15% v/v) versus water concurrent schedule reinforcement, (0 30 mg/kg,...
Abstract Long‐term alcohol exposure produces neuroadaptations that contribute to the progression of abuse disorders. Chronic consumption results in strengthened excitatory neurotransmission and increased α‐amino‐3‐hydroxyl‐5‐methyl‐4‐isoxazole‐propionate receptors ( AMPA ) receptor signaling animal models. However, mechanistic role enhanced activity alcohol‐reinforcement alcohol‐seeking behavior remains unclear. This study examined function using selective positive allosteric modulator,...