A5076722582- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Organ Transplantation Techniques and Outcomes
- Stress Responses and Cortisol
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Neurological disorders and treatments
- Chemical Synthesis and Analysis
- Neural dynamics and brain function
- Child Development and Digital Technology
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Connexins and lens biology
- Nicotinic Acetylcholine Receptors Study
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
Duke Medical Center
2025
University of North Carolina at Chapel Hill
2018-2024
Duke University
2024
Medical University of South Carolina
2012-2015
East Tennessee State University
2011-2012
University of Iowa
1988-1990
Background The prefrontal cortex ( PFC ) acts as an integrative hub for the processing of cortical and subcortical input into meaningful efferent signaling, permitting complex associative behaviors. dysfunction is consistently observed with ethanol (EtOH) dependence a core component pathology alcohol use disorders in current models addiction. While intracortical gamma‐aminobutryric acid (GABA)ergic neurotransmission understood to be essential maintaining coordinated network activity within...
Background. Ex vivo kidney perfusion is an evolving platform that demonstrates promise in preserving and rehabilitating the grafts. Despite this, there little consensus on optimal conditions. Hypothermic offers limited functional assessment, whereas normothermic requires a more complex mechanical system perfusate. Subnormothermic machine (SNMP) has potential to combine advantages of both approaches but undergone investigation. Therefore, present study sought determine suitability SNMP for...
The granule cell layer of the cerebellum functions in spatio-temporal encoding information. Granule cells (GCs) are tonically inhibited by spillover GABA released from Golgi and this tonic inhibition is facilitated acute ethanol. Recently, it was demonstrated that a specialized Ca(2+)-activated anion-channel, bestrophin1 (Best1), found on glial cells, can release contributes up to 50-75% GABAergic current. However, unknown if ethanol has any actions Best1 function. Using whole-cell...
Maternal smoking during pregnancy is associated with enduring psychopathology, such as increased likelihood of substance use, in offspring. Various animal models demonstrate that continuous nicotine exposure produces teratogenic effects offspring, well. In this experiment, a novel intravenous (IV) model was used to determine if gestational (GN) treatment produced alterations methamphetamine-induced sensitization and the expression brain-derived neurotrophic factor (BDNF) mesocorticolimbic...
This study analyzed repeated methylphenidate (MPH) administration and its effects on brain-derived neurotrophic factor (BDNF) in the dorsal striatum nucleus accumbens of male female adolescent rats. In Experiment 1, rats were administered intraperitoneal (ip) saline, 3, or 5 mg/kg dose MPH every second day from postnatal (P)33–P49. Locomotor activity was for 10 min after each administration. Results revealed that 1 produced locomotor suppression, however, sensitization robust behavioral...
Abused inhalants are voluntarily inhaled at high concentrations to produce intoxicating effects. Results from animal studies show that the abused inhalant toluene triggers behaviors, such as self-administration and conditioned place preference, which commonly associated with addictive drugs. However, little is known about how affects neurons within nucleus accumbens (NAc), a brain region basal ganglia mediates goal-directed behaviors implicated in development maintenance of behaviors. Here...
Background. The clinical success of liver transplantation has led to increased demand, requiring further expansion the donor pool. Therapeutic interventions optimize organs from donation after circulatory death (DCD) have significant potential mitigate organ shortage. Dysfunction in DCD grafts is mediated by microvascular thrombosis during warm ischemic period, and strategies that reduce this thrombotic burden may improve graft function. We hypothesized administration fibrinolytic enzyme...
The N‐methyl‐D‐aspartate (NMDA) receptor is a ligand‐gated ionotropic activated by the neurostransmitter glutamate and essential to fast excitatory neurotransmission. NMDARs are heteromeric tetramers composed of obligate GluN1 subunits as well GluN2 or GluN3 subunits. Four distinct types (GluN2A‐D) known impart divergent properties including changes in agonist affinity channel gating. In present study, we identified sequence amino acids pre‐TM4 region GluN2B that affects ligand effectiveness...
ABSTRACT Long-term alcohol use results in behavioral deficits including impaired working memory, elevated anxiety, and blunted inhibitory control that are associated with prefrontal cortical (PFC) dysfunction. Preclinical observations demonstrate multiple impairments GABAergic neurotransmission onto deep-layer principal cells (PCs) prelimbic cortex suggest dependence-related dysfunction is the product of excitability these cells. Despite accumulating evidence showing alcohol-induced changes...