A5038456304- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Sleep and related disorders
- Reformation and Early Modern Christianity
- Medieval Literature and History
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Historical and Linguistic Studies
- Nicotinic Acetylcholine Receptors Study
- Musicology and Musical Analysis
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Biblical Studies and Interpretation
- Fungal and yeast genetics research
- Comics and Graphic Narratives
- Adipose Tissue and Metabolism
- Classical Antiquity Studies
- Historical Studies and Socio-cultural Analysis
- Diverse Musicological Studies
- Music History and Culture
Texas A&M University
2016-2024
Walt Disney (United States)
2024
Royal Netherlands Academy of Arts and Sciences
2024
Netherlands Institute for Neuroscience
2024
Mitchell Institute
2023
Villanova University
2013-2021
Cincinnati Children's Hospital Medical Center
2021
University of Cincinnati
2021
Medical University of South Carolina
2008-2019
Texas Oncology
2017
Eleven studies now report significant associations between schizophrenia and certain haplotypes of single-nucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3. Dysbindin-1 is best known as dystrobrevin-binding protein 1 (DTNBP1) may thus be associated with dystrophin glycoprotein complex found postsynaptic sites brain. Contrary to expectations, however, we that when compared matched, nonpsychiatric controls, 73–93% cases two populations displayed presynaptic reductions...
Eleven studies now report significant associations between schizophrenia and certain haplotypes of single-nucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3. Dysbindin-1 is best known as dystrobrevin-binding protein 1 (DTNBP1) may thus be associated with dystrophin glycoprotein complex found postsynaptic sites brain. Contrary to expectations, however, we that when compared matched, nonpsychiatric controls, 73–93% cases two populations displayed presynaptic reductions...
Abstract The orexin/hypocretin system has recently been implicated in reward‐processing and addiction. We examined the involvement of orexin cue‐induced reinstatement extinguished cocaine‐seeking by administering 1 receptor antagonist SB‐334867 (SB) or 2 4‐pyridylmethyl ( S )‐ tert ‐leucyl 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline (4PT) prior to testing. Male Sprague Dawley rats self‐administered cocaine 2‐h sessions for 10 days, followed extinction training. Reinstatement was elicited...
Abstract The orexin/hypocretin system is involved in several addiction‐related behaviors. In the present experiments, we examined involvement of orexin heroin reinforcement and relapse by administering 1 receptor antagonist SB‐334867 prior to self‐administration or cue‐induced heroin‐induced reinstatement extinguished seeking male Sprague Dawley rats. (30 mg/kg, intraperitoneal) reduced intake during under fixed ratio‐1 progressive ratio schedules. also attenuated elicited cues, but not a...
Relapse to drug use can be initiated by drug-associated cues. The intensity of cue-induced relapse is correlated with the induction transient synaptic potentiation (t-SP) at glutamatergic synapses on medium spiny neurons (MSNs) in nucleus accumbens core (NAcore) and requires spillover glutamate from prefrontal cortical afferents. We used a rodent self-administration/reinstatement model show that t-SP reinstated cocaine seeking result spillover, initiating metabotropic receptor 5...
Addictive substance use impairs cognitive flexibility, with unclear underlying mechanisms. The reinforcement of is mediated by the striatal direct-pathway medium spiny neurons (dMSNs) that project to substantia nigra pars reticulata (SNr). Cognitive flexibility cholinergic interneurons (CINs), which receive extensive inhibition. Here, we hypothesized increased dMSN activity induced inhibits CINs, reducing flexibility. We found cocaine administration in rodents caused long-lasting...
Abstract Alcohol dependence promotes neuroadaptations in numerous brain areas, leading to escalated drinking and enhanced relapse vulnerability. We previously developed a mouse model of ethanol which repeated cycles chronic intermittent (CIE) vapor exposure drive significant escalation voluntary drinking. In the current study, we used this evaluate changes neuronal activity (as indexed by c‐Fos expression) throughout acute protracted withdrawal from CIE (combined with or without history...
Exposure to addictive substances impairs flexible decision making. Cognitive flexibility is mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking alters cognitive through CINs remains unclear. Here, we report that consumption and withdrawal impaired reversal of instrumental learning. Chronic also caused a long-lasting (21 days) reduction excitatory thalamic inputs onto reduced pause responses in the dorsomedial striatum (DMS). are known inhibit...
Summary The transcription of the yeast FBP1 and PCK1 genes, which encode gluconeogenic enzymes fructose‐1,6‐bisphosphatase phosphoenolpyruvate car‐boxykinase, is repressed by glucose. Here, we show that this repression both very strong exceptionally sensitive to glucose, being triggered glucose at concentrations less than 0.005% (0.27 mM). This remains operative in mutants carrying any one three hexose kinases, but lost a triple hxk1, hxk2, glk1 mutant. In addition, 2‐deoxyglucose can...
Addiction is characterized by continued drug use despite negative consequences. In an animal model, a subset of rats continues to self-administer cocaine footshock consequences, showing punishment resistance. We sought test the hypothesis that resistance arises from failure exert goal-directed control over habitual seeking. While habits are not inherently permanent or maladaptive, under conditions should encourage makes them maladaptive and inflexible. trained male female Sprague Dawley on...