A5018607314- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Congenital heart defects research
- Genetic Associations and Epidemiology
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Health, Environment, Cognitive Aging
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Music Perception
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cognitive Abilities and Testing
- Face Recognition and Perception
- Olfactory and Sensory Function Studies
- Genomic variations and chromosomal abnormalities
California University of Pennsylvania
2012-2025
University of Pennsylvania
2016-2025
Children's Hospital of Philadelphia
2016-2025
Lifespan
2017-2025
University of Pennsylvania Health System
2000-2025
VA Connecticut Healthcare System
2007-2024
Yale University
2007-2024
California Department of Education
2023-2024
Philadelphia University
1994-2024
Humboldt-Universität zu Berlin
2024
Significance Sex differences are of high scientific and societal interest because their prominence in behavior humans nonhuman species. This work is highly significant it studies a very large population 949 youths (8–22 y, 428 males 521 females) using the diffusion-based structural connectome brain, identifying novel sex differences. The results establish that male brains optimized for intrahemispheric female interhemispheric communication. developmental trajectories females separate at...
Since initial reports regarding the impact of motion artifact on measures functional connectivity, there has been a proliferation participant-level confound regression methods to limit its impact. However, many most commonly used techniques have not systematically evaluated using broad range outcome measures. Here, we provide systematic evaluation 14 in 393 youths. Specifically, compare according four benchmarks, including residual relationship between and distance-dependent effects network...
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...
Sex-related differences in behavior are extensive, but their neuroanatomic substrate is unclear. Indirect perfusion data have suggested a higher percentage of gray matter (GM) left hemisphere cortex and women, volumes the major cranial compartments not been examined for entire brain association with cognitive performance. We used volumetric segmentation dual echo (proton density T2-weighted) magnetic resonance imaging (MRI) scans healthy volunteers (40 men, 40 women) age 18-45....
Although it is documented that brain dopamine activity declines with age, the functional significance of this not known. This study assessed relation between measures and indexes motor cognitive function in healthy individuals.Thirty volunteers aged 24-86 years were studied positron emission tomography [11C]raclopride to assess D2 receptors. All subjects underwent a neuropsychological test battery included tasks found be sensitive alterations patients neurodegenerative disease control...
The authors used color photographs of emotional and neutral expressions to investigate recognition patterns five universal emotions in schizophrenia.Twenty-eight stable outpatients with schizophrenia (19 men nine women) 61 healthy subjects (29 32 completed an emotion discrimination test that presented mild extreme intensities happy, sad, angry, fearful, disgusted, faces, balanced for gender ethnicity. Analyses evaluated accuracy identifying as a function intensity, diagnosis, poser...
A major barrier to developing treatments for negative symptoms has been measurement concerns with existing assessment tools. Fulfilling the top recommendation of National Institute Mental Health's Consensus Development Conference on Negative Symptoms, Clinical Assessment Interview Symptoms (CAINS) was developed using an iterative, empirical approach, and includes items assessing motivation, pleasure, emotion expression. The authors employed multiple analytic techniques develop CAINS here...
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what believe is first ever large-scale coordinated study WM microstructural differences schizophrenia. Our analysis consisted 2359 healthy controls 1963 patients from 29 independent international studies; harmonized processing statistical analyses...
Abstract COVID-19 pandemic is a global calamity posing an unprecedented opportunity to study resilience. We developed brief resilience survey probing self-reliance, emotion-regulation, interpersonal-relationship patterns and neighborhood-environment, applied it online during the acute outbreak (April 6–15, 2020), on crowdsourcing research website ( www.covid19resilience.org ) advertised through social media. evaluated level of stress (worries) regarding COVID-19: (1) contracting, (2) dying...
Cross-sectional neuroanatomical studies have reported abnormalities in schizophrenia that relate to disease variables. Longitudinal neuroimaging investigations integrate anatomical, clinical, and neurobehavioral measures may help clarify the pathogenesis of schizophrenia.Magnetic resonance brain imaging were conducted at baseline after 30.63 +/- 12.92 months (mean SD) 40 patients with (23 men 17 women) healthy controls (13 4 women). The group included 20 first-episode previously treated...
Emotion processing deficits are notable in schizophrenia. The authors evaluated cerebral blood flow response schizophrenia patients during facial emotion to test the hypothesis of diminished limbic activation related emotional relevance stimuli.Fourteen with and 14 matched comparison subjects viewed displays happiness, sadness, anger, fear, disgust as well neutral faces. Functional magnetic resonance imaging was used measure blood-oxygen-level-dependent signal changes alternated between...
Examine age group effects and sex differences by applying a comprehensive computerized battery of identical behavioral measures linked to brain systems in youths that were already genotyped. Such information is needed incorporate data as neuropsychological "biomarkers" large-scale genomic studies.
The facial discrimination tasks described in part I (Erwin et al., 1992) were administered to a sample of 14 patients with depression and normal controls matched for sex (12 women, 2 men) balanced age sociodemographic characteristics. Patients performed more poorly on measures sensitivity happy specificity sad discrimination, had higher negative bias across tasks. Severity affect was correlated poorer performance patients. results suggest that is associated an impaired ability recognize...