A5062398628- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Liver Disease and Transplantation
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Mechanical Circulatory Support Devices
- Cancer Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- HER2/EGFR in Cancer Research
- Fusion materials and technologies
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cardiac Fibrosis and Remodeling
- Radiomics and Machine Learning in Medical Imaging
- Synthesis and biological activity
- Adenosine and Purinergic Signaling
- Gastric Cancer Management and Outcomes
- Microbial metabolism and enzyme function
Saitama Red Cross Hospital
2024-2025
Duke Medical Center
2022-2025
National Hospital Organization Saitama Hospital
2024-2025
Okayama University
2001-2024
Duke University Hospital
2023-2024
Duke University
2022-2024
Okayama University Hospital
2019-2023
National Institutes for Quantum Science and Technology
2017-2023
Kyushu University
2021
Shikoku Cancer Center
2018
Mechanisms underlying primary and acquired resistance to MET tyrosine kinase inhibitors (TKIs) in managing non-small cell lung cancer remain unclear. In this study, we investigated the possible mechanisms for crizotinib -amplified carcinoma lines. Two lines, EBC-1 H1993, were established MET-TKI functionally elucidated. Genomic transcriptomic data used assess factors contributing mechanism, alterations hypothesized confer validated. Multiple underlie EBC-1-derived resistant cells,...
Background. Ex vivo kidney perfusion is an evolving platform that demonstrates promise in preserving and rehabilitating the grafts. Despite this, there little consensus on optimal conditions. Hypothermic offers limited functional assessment, whereas normothermic requires a more complex mechanical system perfusate. Subnormothermic machine (SNMP) has potential to combine advantages of both approaches but undergone investigation. Therefore, present study sought determine suitability SNMP for...
Silicon was doped to hydroxyapatite by hydrothermal techniques for higher biocompatibility. Products contained tetra-ethyl-orthosilicate (TEOS) as a silicon source in the range of 0 15 mass%. In order evaluate bioactivity silicon-doped hydroxyapatite, samples were soaked simulated body fluid (SBF). showed faster apatite forming ability than undoped samples. The examined transmission electron microscopy (TEM), X-ray diffraction patterns (XRD), Fourier transform infrared spectroscopy (FTIR)...
Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment that mediate resistance cancer cells to anticancer drugs. Tranilast is an antiallergic drug suppresses release cytokines from various inflammatory cells. In this study, we investigated inhibitory effect tranilast on interactions between non-small cell lung (NSCLC) and CAFs in microenvironment. Three EGFR-mutant NSCLC lines, two KRAS-mutant three derived patients were used. To mimic microenvironment,...
In patients undergoing radiotherapy for localized prostate cancer, dose–volume histograms and clinical variables were examined to search correlations between radiation treatment planning parameters late rectal bleeding. We analyzed 129 with cancer who managed from 2002 2010 at our institution. They treated 3D conformal therapy (3D-CRT, 70 Gy/35 fractions, 55 patients) or intensity-modulated (IMRT, 76 Gy/38 74 patients). All plans retrospectively reconstructed, of the rectum generated, doses...
Abstract Molecular‐targeted therapies directed against human epidermal growth factor receptor 2 (HER2) are evolving for various cancers. Neratinib is an irreversible pan‐HER tyrosine kinase inhibitor and has been approved by the FDA as effective drug HER2‐positive breast cancer. However, acquired resistance of cancers to molecular‐targeted drugs issue clinical concern, emergence neratinib also considered inevitable. In this study, we established types neratinib‐resistant cell lines from HER2...
During ischemia reperfusion (IR) injury, high mobility group box 1 (HMGB1), a chromatin binding protein, is released from necrotic cells and triggers inflammatory responses. We assessed the therapeutic effect of neutralizing anti-HMGB1 monoclonal antibody (mAb) on lung IR injury. A murine hilar clamp model was used, where mice were divided into sham groups with intravenous administration anti-HMGB mAb or control mAb. analyzed against injury by assessing oxygenation, score, neutrophil...
ObjectiveLow-dose-rate (LDR) brachytherapy is an effective treatment for tongue cancer. However, little known about the biological mechanism underlying this therapy, characterized by delivery of continuous exposures LDR irradiation. It reported that lower microvessel density (MVD), Ki-67 index or higher expression endogenous hypoxic markers such as carbonic CA IX and Glut-1 are related to poor control tumors treated with external To elucidate characteristics brachytherapy, we analyzed our...
Abstract One-step nucleic acid amplification (OSNA) is a rapid intraoperative molecular detection technique for sentinel node assessment via the quantitative measurement of target cytokeratin 19 ( CK19 ) mRNA to determine presence metastasis. It has been validated in breast cancer but its application lung not adequately investigated. 214 LNs from 105 patients with 100 primary cancers, 2 occult tumors, and 3 metastatic who underwent surgical resection LN dissection between February 2018...
The therapeutic strategy for patients with non-small-cell lung cancer (NSCLC) harboring the BRAF non-V600E mutation has not been established. LY3009120, a newly discovered pan-RAF inhibitor, shown strong antitumor effects in cancers various genotypes. This study investigated of LY3009120 NSCLC cells mutation.We examined by MTS assay and flow cytometry. We analyzed expression status proteins western blot. mouse xenograft models were used vivo experiments.LY3009120 suppressed BRAF-related...
Effect of SiO2 addition on the microstructures calcium-deficient hydroxyapatite prepared by heat-treatments was examined. Obtained hydroxyapatites substituted with Si ion were characterized XRD, FT-IR and XAFS measurements. XANES results K-edge P in these modified indicated shift peaks contents, although no change local structures. In this study, effect micro- structure mainly clarified.
(1) Background: Lung ischemia–reperfusion (IR) injury increases the mortality and morbidity of patients undergoing lung transplantation. The objective this study was to identify key initiator IR evaluate pharmacological therapeutic approaches using a functional inhibitor against identified molecule. (2) Methods: Using mouse hilar clamp model, combination RNA sequencing histological investigations revealed that neutrophil-derived S100A8/A9 plays central role in inflammatory reactions during...