A5017226872- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiovascular Syncope and Autonomic Disorders
- Vascular anomalies and interventions
- Sports injuries and prevention
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Sarcoidosis and Beryllium Toxicity Research
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Heart Failure Treatment and Management
- Orthopedic Surgery and Rehabilitation
- Fuel Cells and Related Materials
Sakakibara Hospital
2019-2025
Saitama Red Cross Hospital
2013-2024
National Hospital Organization Saitama Hospital
2017-2024
Ministry of Health Labour and Welfare
2022
Sakakibara Memorial Hospital
2021
Tokyo Medical and Dental University
1990-2020
Saitama Prefecture
2018
Sapporo Medical University
2016
Musashino Red Cross Hospital
2001-2014
Baylor College of Medicine
1995-1996
Fatal arrhythmia is commonly observed in cardiac sarcoidosis, but clinical effects of a systematic treatment approach are still uncertain. This study sought to describe both and electrophysiological characteristics outcomes ventricular tachycardia (VT) associated with sarcoidosis.
Successful bipolar radiofrequency catheter ablation (RFCA) of refractory ventricular arrhythmias (VAs) has been reported. However, the efficacy, safety, and long-term outcomes RFCA VAs are not fully determined.The purpose this study was to evaluate effectiveness safety in treating during follow-up.Eighteen patients who underwent for tachycardia (VT) at 7 institutions were retrospectively investigated. Underlying heart diseases included remote myocardial infarction (n = 3 [17%]) nonischemic...
Endothelin-1 (ET-1), a 21-amino acid vasoconstrictive peptide, increases intracellular Ca2+ level and has hypertrophic action on ventricular myocytes. To elucidate possible role of entry through sarcolemmal channels this ET-1 action, we examined effects L-type (ICa,L) T-type (ICa,T) currents in cultured neonatal rat myocytes using the patch-clamp technique. at concentration 10 nM increased maximum current density ICa,T from -3.0 +/- 1.4 microA/cm2 control condition to -4.4 1.6 (p < 0.01)....
Abstract Background and aims Early rhythm-control therapy in atrial fibrillation (AF) results higher freedom from arrhythmia (AA) recurrence improved cardiovascular outcomes. The optimal timing of Cryoballoon ablation (CBA) is unknown. Methods We evaluated AA procedure-related complications early vs. late CBA (≤12 &gt;12 months diagnosis) patients enrolled the prospective Cryo Global Registry (121 centers 37 countries, NCT02752737). Results A total 3447 subjects were followed through 12...
ABSTRACT Introduction Freedom from recurrences of atrial tachyarrhythmia (ATA) is suboptimal after pulmonary vein isolation (PVI) in patients with persistent fibrillation (PsAF). This sub‐analysis the Cryo Global Registry sought to investigate predictors ablation success PVI using cryoballoon (CBA) for PsAF. Methods and Results ATA recurrence was defined as ≥ 30 s fibrillation, flutter or tachycardia a 90‐day blanking period through 12‐months. Univariate multivariable Cox regression analysis...
ABSTRACT Background POLARx FIT is a size‐adjustable cryoballoon, but its effect on isolation area and phrenic nerve injury (PNI) not fully understood. This study aimed to compare the effects of 28 31 mm cryoballoon left atrium (LA), superior vena cava (SVC), PNI incidence. Methods Results Thirty‐one cases paroxysmal atrial fibrillation treated with were analyzed. SVC voltage mapping septal sleeve length measurements performed before pulmonary vein (PV) isolation. A balloon was used isolate...
Introduction: Radiofrequency catheter ablation (RFCA) of severely symptomatic monomorphic ventricular premature beats (VPBs) is reported to be a safe and effective treatment option. However, the chronic hemodynamic effects these VPBs have not been precisely evaluated. Methods Results: We sought investigate after decreasing number by RFCA. A total 47 patients who had no underlying heart disease frequent VPBs, consisting more than 10,000 per day (24,194 ± 12,516 day), were enrolled. Patients...
Intracellular Ca2+ augments delayed rectifier K+ current (IK) in cardiac myocytes, which may play a major modulatory role repolarization of action potentials. We investigated subcellular mechanisms for Ca(2+)-induced enhancement IK large-pipette inside-out membrane patches excised from isolated guinea pig ventricular myocytes. When [Ca2+]i was raised 10(-8) to 10(-6) mol/L, the amplitude measured at +80 mV increased 12.0 +/- 2.2 19.5 3.3 pA (P < .01). The by dose dependent, with an EC50...
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The clinical characteristics of atrial fibrillation (AF) resulting from non-pulmonary vein (PV) triggers remain unknown. This study aimed to evaluate the patients with AF caused by non-PV triggers, localization foci, differences, and outcomes after catheter ablation in each focus.A total 2967 who underwent initial for paroxysmal or persistent were examined. After PV isolation, all high-dose isoproterenol infusion assess existence foci.Non-PV foci identified 564 (19.2%). successfully ablated...
NOGAMI, A., et al. : Enhancement of J–ST‐Segment Elevation by the Glucose and Insulin Test in Brugada Syndrome. The effects glucose insulin on J–ST‐segment elevation were evaluated seven men (mean age 45 ± 10 years) with syndrome. Six patients had been reanimated from VF one patient experienced syncope. intravenous (1) pilsicainide 50 mg, (2) g, (3) g plus regular IU precordial ECG leads examined. Pilsicainide significantly enhanced J‐ST all induced 1 patient. A significant accentuation...
Background Both endocardial trigger elimination and epicardial substrate modification are effective in treating ventricular fibrillation (VF) Brugada syndrome. However, the primary approach characteristics of patients who respond to ablation remain unknown. Methods Among 123 symptomatic syndrome (VF, 63%; syncope, 37%), was performed 21 VF/electrical storm patients, majority whom were resistant antiarrhythmic drugs. Results Careful mapping revealed that 81% had no specific findings, whereas...
Catheter ablation is a recommended rhythm control therapy after failed or intolerant antiarrhythmic drug (AAD) treatment for patients with atrial fibrillation (AF). This study evaluates clinical performance and safety of pulmonary vein isolation (PVI) using the cryoballoon (Arctic Front Advance) in Japan.Cryo AF Global Registry prospective, multi-center registry. Patients paroxysmal (PAF) were treated at 10 Japanese hospitals. Efficacy was evaluated by freedom from ≥ 30-s recurrence...
The POLARx FIT system (Boston Scientific, MA, USA) is a novel cryoballoon (CB) ablation technology in which the balloon diameter can be expanded from 28 to 31 mm. aim of this study was compare benefits and safety new those existing currently use for pulmonary vein (PV) isolation (PVI) patients with atrial fibrillation.
Background: We investigated four factors, height, weight gain since age 20, physical activity, and alcohol drinking, for associations with risk of breast cancer (BC) according to menopausal status, using the latest data Japan Collaborative Cohort Study (JACC Study). Materials Methods: confined analysis 24 areas available incidence information, excluding women a previous diagnosis BC. Baseline were collected from 38,610 (9,367 premenopausal, 29,243 postmenopausal) during 1988 1990. The study...
Pulmonary vein isolation (PVI) using cryoballoon is effective for patients with paroxysmal atrial fibrillation (PAF); however, few reports have evaluated the non-pulmonary (PV) foci after ablation. We aimed to evaluate characteristics of non-PV and predictors (AF) recurrence ablation.This was a single-center retrospective study 647 PAF who underwent initial PVI second-generation cryoballoon. After PVI, all high-dose isoproterenol infusion assess existence foci. Non-PV were observed in 211...