A5036058113- Bariatric Surgery and Outcomes
- Nitric Oxide and Endothelin Effects
- Neuroendocrine Tumor Research Advances
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Antibiotics Pharmacokinetics and Efficacy
- Diabetes Management and Research
- Cardiac electrophysiology and arrhythmias
- Gastric Cancer Management and Outcomes
- Body Contouring and Surgery
- Pancreatic and Hepatic Oncology Research
- Soft tissue tumor case studies
- Cardiac Fibrosis and Remodeling
- Growth Hormone and Insulin-like Growth Factors
- Obesity and Health Practices
- Diabetes Management and Education
- Heart Failure Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Esophageal Cancer Research and Treatment
- Immune Response and Inflammation
Tokyo Metropolitan Tama Medical Center
2013-2025
Fuchu Hospital
2000-2008
Tokyo Medical and Dental University
1989-1997
Hirosaki University
1996
Takeda (Japan)
1995
Hokushin General Hospital
1990-1992
Tokyo Women's Medical University
1989-1991
Ōtani University
1989
Shinshu University
1989
Osaka University
1967-1970
To elucidate the cellular mechanism by which angiotensin II (ANG II) induces cardiac hypertrophy, we investigated possible autocrine/paracrine role of endogenous endothelin-1 (ET-1) in ANG II-induced hypertrophy neonatal rat cardiomyocytes use synthetic ET-1 receptor antagonist and antisense oligonucleotides to preproET-1 (ppET-1) mRNA. Northern blot analysis situ hybridization revealed that ppET-1 mRNA was expressed cardiomyocytes, but, a lesser extent, nonmyocytes as well. upregulated...
To determine whether endothelin-1 (ET-1) induces hypertrophy of cardiomyocytes, the effects ET-1 on expression muscle-specific genes and a proto-oncogene, c-fos, in cultured neonatal rat cardiomyocytes were examined by Northern blot analysis. (10(-7) M) induced about twofold to fourfold increases gene myosin light chain 2, alpha-actin, troponin I after 6 hours, which continued up 24 hours. The ET-1-induced mRNA levels for these dose dependent (10(-9) 10(-7) M). Run-on transcriptional assay...
BACKGROUND Cardiac hypertrophy is commonly observed in acromegalic patients, whom serum insulin-like growth factor-I (IGF-I) levels are elevated. In the present study, we examined whether IGF-I induces cultured neonatal rat cardiomyocytes through its specific receptor and IGF binding protein-3 (IGFBP-3), which a major circulating carrier protein for IGF-I, inhibits IGF-I-induced cardiac vitro. METHODS AND RESULTS Because response of characterized by induction expression muscle-specific...
BACKGROUND Impaired myocardial contractility in septic shock is protracting, which may be caused by cytokine-induced nitric oxide (NO) synthesis the heart. However, cellular mechanism cytokines induce synthase (NOS) cardiocytes remains obscure. METHODS AND RESULTS We studied effect of human recombinant interleukin-1 beta (IL-1 beta) on NO2-/NO3- (NOx) and expression NOS mRNA protein cultured neonatal rat cardiocytes. IL-1 dose-dependently (0.1 to 10 ng/mL) stimulated NOx production as a...
Endothelin-1 (ET-1), a 21-amino acid vasoconstrictive peptide, increases intracellular Ca2+ level and has hypertrophic action on ventricular myocytes. To elucidate possible role of entry through sarcolemmal channels this ET-1 action, we examined effects L-type (ICa,L) T-type (ICa,T) currents in cultured neonatal rat myocytes using the patch-clamp technique. at concentration 10 nM increased maximum current density ICa,T from -3.0 +/- 1.4 microA/cm2 control condition to -4.4 1.6 (p < 0.01)....
Abstract Aim Laparoscopic sleeve gastrectomy ( LSG ) is becoming popular in Japan, but insufficient weight loss often observed patients after . We investigated the effect of on obesity‐related comorbidities and identified background characteristics Japanese with Methods In this multi‐institutional retrospective study at 10 certified bariatric institutions, 322 who underwent a follow‐up period more than 2 years were analyzed. Anthropometry, psychosocial data collected. Weight was expressed as...
A 31-year-old Japanese man was admitted with a slight fever and epigastric pain. He had received his third Moderna COVID-19 vaccine dose (Spikevax, mRNA-1273) 16 days before visit. His serum amylase level elevated, computed tomography (CT) found pancreatic enlargement. Acute pancreatitis diagnosed, the patient treated fasting intravenous fluids. However, on day 3 of hospitalization, blood glucose increased to 320 mg/dL. urinary C-peptide were remarkably low (≤0.03 ng/mL ≤0.6 μg/day,...
Background There exists a subpopulation of T2DM in whom first-line doses statin are insufficient for optimally reducing LDL-C, representing major risk CVD. The RESEARCH study focuses on LDL-C reduction this population along with modifications the lipid profiles leading to residual risks. Methods Lipid changes were assessed randomized, multicenter, 12-week, open-label comparing high-potency (10mg atorvastatin or 1mg pitavastatin) plus ezetimibe (EAT: n = 53) double dose (20mg 2mg (DST: 56) DM...
Introduction: Laparoscopic sleeve gastrectomy (LSG) for morbidly obese patients often results in remission of type 2 diabetes (T2DM), but relapses some those patients. The frequency T2DM relapse Asians and the factors involved have not been adequately investigated. Methods: J-SMART study was conducted on 322 Japanese subjects with body mass index (BMI) ≥32 kg/m2 who underwent LSG at 10 accredited centers Japan between 2011 2014. Of these, 82 complete or partial 1 year after followed...
Diazoxide is recognized as an effective medical treatment for insulinoma. However, due to its adverse effects, such fluid retention, it sometimes difficult employ diazoxide at dose in clinical practice. This study aimed clarify the factors, which may affect efficacy and safety of treatment. We retrospectively evaluated records 20 patients with insulinoma including 4 malignant cases. The were divided into two groups according presence or absence favorable outcomes features both compared. was...
Our objective was to describe cases of hyperosmolar hyperglycemic state (HHS) in advanced amyotrophic lateral sclerosis (ALS) patients and discuss its pathophysiology. Five ventilator-dependent with ALS, no previous history diabetes, showed development marked hyperglycemia (plasma glucose levels 755–1544 mg/dl) after preceding infectious episodes. All had severe generalized muscle wasting tetraplegia. The initial manifestations HHS were fever, drowsiness, or polyuria. Hydration intravenous...
The most common cause of hyperinsulinemic hypoglycemia in adults is insulinoma. Nesidioblastosis a rare, but well-recognized disorder persistent infancy, adult-onset nesidioblastosis associated with hypoglycemia, termed noninsulinoma pancreatogenous hypoglycemic syndrome (NIPHS), has been reported. Here, we describe an extremely rare case NIPHS elderly man. A 78-year-old man was admitted to our hospital due coma. During the previous 3 months, he noticed excessive sweating at midafternoon....
<b><i>Introduction:</i></b> The psychosocial background of subjects with severe obesity developed from childhood onset (CO) and their outcomes after bariatric surgery have not been fully investigated. <b><i>Methods:</i></b> 305 were enrolled in the J-SMART study, which examined effects laparoscopic sleeve gastrectomy (LSG) Japan, categorized into two groups: CO defined as up to 13 years age (CO group) post-puberty (PPO group). followed for at...
In the Prussian Blue method for histochemical demonstration of iron, some parts produced pigment are considerably washed away during dyeing process, because is water soluble. Consequently decrease and diffusion occur staining surrounding tissues take place. The color reaction was carried out in 70% acetone solution order to solubility pigment. Obtaining sharp clear demarcation, this applied successfully colloidal iron acid mucopolysaccharides very strong obtained.
We investigated kallikrein-binding protein (KBP) mRNA distribution in the kidney of Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR), and Wistar-Kyoto strain (WKY) rats. Northern blot analysis revealed that KBP was located mainly medulla with lower amounts SHR than WKY microdissected nephron segments detected by reverse transcription polymerase chain reaction (RT-PCR) followed Southern analysis. In SD most abundant signals were consistently found inner medullary collecting...
A 70-year-old man with diabetes mellitus presented an enlarged pituitary stalk in 2014. IgG4-related parotitis and submandibular sialoadenitis were diagnosed 2012. He denied any symptoms related to a mass. His visual field was intact, his hypopituitarism subtle. The serum IgG4 level elevated. lip biopsy revealed strong fibrosis hyper-infiltration of IgG4-positive plasma cells. Based on these findings, hypophysitis diagnosed. patient carefully followed without specific intervention. clinical...
An 81-year-old woman presented with frequent episodes of hypoglycemia. Her serum level insulin was normal, but her insulin-like growth factor (IGF)-II high. She found to have a spindle cell sarcoma originated from the mesentery sigmoid colon, which completely resected. Postoperatively, hypoglycemia ameliorated concomitant reduction in IGF-II levels. Immunohistochemical study revealed positive immunostaining for tumor cells, and abundant expression mRNA demonstrated by RT-PCR. The presence...
Gigantomastia is characterised by excessive breast growth and can occur as a rare, drug-induced adverse event. D-penicillamine the most frequent cause of gigantomastia. Only one case gigantomastia due to bucillamine, an analogue D-penicillamine, has been reported so far. We herein report bucillamine-induced presenting with acute enlargement bilateral breasts accessory tissue in axillae 7 months after start bucillamine therapy. Awareness about this rare event important since still widely used...