A5037201209- DNA Repair Mechanisms
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Carcinogens and Genotoxicity Assessment
- Lung Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Genetic factors in colorectal cancer
- Advances in Oncology and Radiotherapy
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Sapporo Medical University
2016-2025
Sapporo Medical University Hospital
2011
Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised 2009, 2013, 2016, 2019. In July 2022, newly Japanese.For this revision, we developed an entirely new guideline according to Minds Manual Guideline Development 2020, which includes concepts of GRADE-Grading Recommendations Assessment, Development, Evaluation, enable a better understanding current guidelines. Patients public were actively involved both development...
Abstract BACKGROUND This was a prospective randomized clinical trial undertaken at our institution to compare low‐dose‐rate (LDR) intracavitary radiation therapy versus high‐dose‐rate (HDR) for the treatment of cervical carcinoma. METHODS From January 1984 December 1997, total 132 patients with Stage II or IIIB invasive carcinoma uterine cervix were entered into this study. Treatment arm by HDR LDR allocated according month each patient's birth. External irradiation consisted whole pelvis...
<title>Abstract</title> Purpose This retrospective study aimed to identify clinical factors associated with prognosis and develop a scoring system predict treatment efficacy in patients differentiated thyroid cancer (DTC) who developed lung metastases following radioiodine therapy (RAI). Methods Among 300 received RAI at our institution between January 1, 2017, December 31, 2022, 74 exhibited metastases. We constructed based on age (< 55 years vs. ≥55 years), the size of 10 mm ≥10 mm),...
Abstract BACKGROUND Non‐Hodgkin lymphoma (NHL) represents a heterogeneous group of tumors that vary with regard to their biologic aggressiveness and clinical course. In in vitro studies, matrix metalloproteinase 9 (MMP9) was reportedly expressed by human NHL cells elevated levels MMP9 have been observed subset patients high‐grade NHL. METHODS The expression MMP2 evaluated 158 the relation between these proteins clinicopathologic factors analyzed. All but 1 patient had received radiation...
The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) an important role with DSBs repair. In this study, 93 untreated cancer patients and 41 cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated centrifuged; DNA-PK activity measured by DNA-pull-down assay. expressions DNA-PKcs, Ku70 Ku86 examined RT–PCR assay western...
Cone-beam CT (CBCT) images acquired during radiation treatment can be used to recalculate the dose distribution as well confirm location. However, it is difficult obtain electron densities (EDs) necessary for calculation from CBCT because of effects scatter contamination image acquisition. This paper presents a mathematical method converting pixel values (CBCT values) into Hounsfield units (HUs) simulation (simCT) use in planning. are converted HUs by matching histograms with each slice via...
Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood. was originally added to oral fluoropyrimidine derivative S-1 yield prolonged concentrations serum and tumor tissues. We have already reported that gimeracil had radiosensitizing effects by partially inhibiting homologous recombination (HR) repair DNA double strand breaks. investigated mechanisms radiosensitization. Comet assay...
Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme involved in the repair of radiation-induced single-strand DNA breaks. PARP inhibitors such as olaparib (KU-0059436, AZD-2281) enhance tumor sensitivity to radiation and topoisomerase I like camptothecin (CPT). Olaparib an orally bioavailable inhibitor PARP-1 PARP-2 that has been tested multiple clinical trials. The purpose this study was investigate characteristics sensitizing effect for CPT order support application agent.DLD-1 cells...
In patients undergoing radiotherapy for localized prostate cancer, dose–volume histograms and clinical variables were examined to search correlations between radiation treatment planning parameters late rectal bleeding. We analyzed 129 with cancer who managed from 2002 2010 at our institution. They treated 3D conformal therapy (3D-CRT, 70 Gy/35 fractions, 55 patients) or intensity-modulated (IMRT, 76 Gy/38 74 patients). All plans retrospectively reconstructed, of the rectum generated, doses...
Some studies showed that clinical response to immune check point inhibitors is lower in acral and mucosal melanoma than cutaneous melanoma. Although the synergistic effect of radiotherapy (RT) ipilimumab has been reported patients with brain metastasis, efficacy combined RT anti-programmed death 1 (PD-1) therapy for unclear. The present study aimed evaluate anti-PD-1 We retrospectively analyzed or who were treated at Sapporo Medical University Hospital. In 10 (acral, 3; mucosal, 7), rate...
Abstract Background Aberrant Notch signaling pathway has been related with the tumorigenesis in head and neck region, involving oral cavity. Here, we report correlation between mutations CD8 + T‐cell infiltration via PD‐L1, which lead to enhanced antitumor immunity may target for immune‐checkpoint inhibitors (ICIs) therapy. Methods This retrospective study analyzed results of immunohistochemical staining PD‐L1 10 patients whole‐exome sequencing (WES) was conducted on five these identify...
Automated measurement of immunostained samples can enable more convenient and objective prediction treatment outcome from radiotherapy. We aimed to validate the performance QuPath image analysis software in immune cell markers detection by comparing counting results with those physician manual counting.
We report our experiences of four cases with meningeal hemangiopericytoma treated surgery and postoperative radiotherapy survey the literature to elucidate efficacy radiotherapy. Patients were surgical resection 46–52 Gy Three patients had local control for 30, 54 138 months, respectively one patient recurrence after 49 months. Distant metastases observed in two patients; multiple bone, liver lung other bone brain metastases. For metastases, better tumor was obtained palliative stereotactic...
Repair of various types DNA damages is critical for genomic stability. DNA-dependent protein kinase (DNA-PK) has an important role in double-strand break repair. We examined whether there may be a correlation between DNA-PK activity peripheral blood lymphocytes (PBLs) and survival percentages cancer patients. also investigated the changes PBLs after radiotherapy.A total 167 untreated patients participated this study. Peripheral was collected, separated, centrifuged. measured by DNA-pull-down...
DNA double-strand break (DSB) is one of the most serious forms damage induced by ionizing irradiation. Non-homologous end-joining (NHEJ) a key mechanism DSB repair. The immunohistochemical analysis proteins involved in NHEJ may have potential as predictive assay for tumor radiosensitivity. We examined correlation between expression biopsy specimens and results chemoradiotherapy hypopharyngeal cancers. Fifty-seven patients with previously untreated squamous cell carcinoma hypopharynx were...