A5004694884- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health in Aging
- Patient Dignity and Privacy
- Frailty in Older Adults
- Patient-Provider Communication in Healthcare
- Grief, Bereavement, and Mental Health
- Family and Patient Care in Intensive Care Units
- Clinical Nutrition and Gastroenterology
- Ethics in medical practice
- Economic and Financial Impacts of Cancer
- Meta-analysis and systematic reviews
- Antifungal resistance and susceptibility
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Pancreatic and Hepatic Oncology Research
- Clinical practice guidelines implementation
- Cancer Genomics and Diagnostics
- Body Composition Measurement Techniques
- Health Sciences Research and Education
- Hepatocellular Carcinoma Treatment and Prognosis
- Intensive Care Unit Cognitive Disorders
- Pericarditis and Cardiac Tamponade
- Optimism, Hope, and Well-being
Kyoto University
2016-2025
Kyoto University Hospital
2015-2024
Wakayama Medical University
2023
European Society for Clinical Nutrition and Metabolism
2023
Hiroshima Kyoritsu Hospital
2021
Tohoku University
2021
Kobe University
2021
National Cancer Center Hospital East
2020
Juntendo University
2020
Seirei Mikatabara General Hospital
2018-2020
Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised 2009, 2013, 2016, 2019. In July 2022, newly Japanese.For this revision, we developed an entirely new guideline according to Minds Manual Guideline Development 2020, which includes concepts of GRADE-Grading Recommendations Assessment, Development, Evaluation, enable a better understanding current guidelines. Patients public were actively involved both development...
Objectives It is unknown to what extent the fluid retention (FR) status disrupts detection of weight loss rate (WLR) in adult patients with advanced cancer. This study aimed determine association FR WLR. Methods was a secondary analysis prospective cohort study. evaluated as follows: oedema (0, no; 1, yes), pleural effusion yes but asymptomatic; 2, symptomatic) and ascites symptomatic). Patients were divided into three groups according their scores: no-FR (0), moderate-FR (1–2) high-FR...
Abstract Background Field cancerization defined by multiple development of squamous cell carcinomas (SCCs) in upper aerodigestive tract was explained excessive alcohol intake. A dysfunctional mitochondrial aldehyde dehydrogenase 2 (Aldh2) delays the clearance acetaldehyde, a genotoxic metabolite, and increases SCC risks. TP53 plays key roles carcinogenesis. However, mechanism alcohol-mediated field has not been clearly elucidated. Methods We developed novel genetically engineered mouse...
Background: Few studies investigated the clinical implications of C-reactive protein-albumin ratio (CAR) in palliative care. Objectives: To determine association CAR with overall survival among terminally ill patients cance. Design: Datasets were obtained through two multicenter prospective cohort studies. Setting/Subjects: Patients newly referred to Measurements: Physicians recorded measures at baseline. followed up their death or observed for 6 months. The 2 divided using cutoffs detected...
Although various phrases to communicate prognoses based on a certain concept have been proposed, no study has systematically investigated preferences of patients with cancer for actual phrases. We whether wider range and additional "hope the best, prepare worst" (hope/prepare) statement would be more preferable explored variables associated patients' preferences.In cross-sectional survey, 412 outpatients self-assessed their 13 conveying prognostic information (e.g., or without median,...
Background We aimed to develop an adaptable prognosis prediction model that could be applied at any time point during the treatment course for patients with cancer receiving chemotherapy, by applying time-series real-world big data. Methods Between April 2004 and September 2014, 4,997 who had received systemic chemotherapy were registered in a prospective cohort database Kyoto University Hospital. Of these, 2,693 death record eligible inclusion divided into training (n = 1,341) test 1,352)...
Abstract Purpose A sudden unexpected death has significant negative impacts on patients, family caregivers, and medical staff in hospice/palliative care. This study aimed to clarify the incidence associated factors of according four definitions advanced cancer patients. Methods We performed a prospective cohort 23 inpatient hospices/palliative care units Japan. Advanced patients aged ≥18 years who were admitted included. The evaluated all enrolled definitions: (a) rapid decline death,...
Introduction An easy-to-access and effective psychotherapy for bereaved informal caregivers has not been established. People with higher self-compassion status tend to have lower bereavement related grief, focused on can be promising this population. This study aimed examine the feasibility of online caregivers. Method analysis A total 60 participants will undergo an intervention programme comprising sessions 2 hours per week five consecutive weeks undertake postsession work. The personnel...
Abstract Background The study aimed to clarify the efficacy of “3‐Day Surprise Question (3DSQ)” in predicting prognosis for advanced cancer patients with impending death. Patients and Methods This was a part multicenter prospective observational which investigated dying process Japan. For Palliative Performance Scale ≤20, 3DSQ “Would I be surprised if this patient died next 3 days?” answered by their physicians. In addition sensitivity specificity 3DSQ, characteristics who survived longer...
Background: Limited information is available on the relationship between C-reactive protein (CRP) levels and pain in advanced cancer. Objectives: To investigate serum of CRP subtypes pain. Design: A secondary cross-sectional analysis a prospective cohort study. Setting/Subjects: Patients with cancer admitted to 23 palliative care units Japan. Measurements: rated severity numerical rating scale (NRS) physicians evaluated integrated outcome (IPOS). Physicians assessed neuropathic breakthrough...
Palliative sedation is sometimes needed for refractory symptoms, and the Richmond Agitation-Sedation Scale (RASS) one of key measures. The primary aim this study was to explore association between RASS degree distress quantified by other measures: Item "symptom control" Support Team Assessment Schedule (STAS, item 2), Discomfort Dementia Alzheimer Type (Discomfort Scale), Noncommunicative Patient's Pain Instrument (NOPPAIN), as well a communication capacity measured Communication Capacity...
Background and objective Implementing electronic patient-reported outcomes (ePROs) in oncology practice has shown substantial clinical benefits. However, it can be challenging routine practice, warranting strategies to adapt different contexts. In light of this, this study aimed describe the implementation process ePRO system elucidate provider-level barriers facilitators a novel at cancer hospitals Japan. Methods We implemented an linked medical records three hospitals. Fifteen patients...
This study aimed to examine the feasibility and effectiveness of online group psychotherapy focused on self-compassion for individuals experiencing bereavement-related grief.
Nivolumab shows promising efficacy against metastatic melanoma. However, immune-related adverse events are of great concern. We herein report a case persistent colitis that developed during nivolumab monotherapy and readministration. An 82-year-old Japanese woman with recurrent melanoma Grade 3 after 6 cycles nivolumab. She was treated corticosteroid for 28 days. Follow-up by computed tomography colonoscopy treatment revealed pancolitis. Her symptoms ameliorated spontaneously in two months....
Background: For cancer patients nearing death, the prediction of their prognosis by physicians is crucial. This study examined usefulness 1-Day Surprise Question (1DSQ). Methods: was conducted as part a multicenter prospective observational study. The answered 1DSQ "Would I be surprised if this patient died in next 1 day?" when have palliative performance scale (PPS) ≤20. We calculated sensitivity and specificity 1DSQ. Moreover, using multivariate analysis, we evaluated characteristics who...
Although radiation esophagitis is one of the most common adverse events that occurs during chemoradiotherapy (CRT) in patients with esophageal cancer, CRT-associated cytomegalovirus (CMV) rare. CMV typically an immunosuppressed status. Here we report a case CRT initially treated as esophagitis. A 64-year-old man mid-thoracic cancer was admitted to our hospital clinical stage cT4bN1M1 (supraclavicular lymph node metastasis) Stage IV according UICC ver. 7 guidelines, and he administered...
The appropriate delivery of death pronouncements potentially affects bereaved families' wellbeing positively. Although younger physicians need to learn the competencies and entrustable professional activities (EPAs) conduct pronouncement independently, both which have not been clarified. Therefore, this study aimed develop a list EPAs necessary for practice, resident acquire by end their residency training (postgraduate year 2).An anonymous modified Delphi was conducted with panel 31...