Jun Nakagawa

ORCID: 0000-0002-9121-6995
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About
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Research Areas
  • Liver Disease Diagnosis and Treatment
  • Trypanosoma species research and implications
  • Palliative Care and End-of-Life Issues
  • Liver Diseases and Immunity
  • Nutrition and Health in Aging
  • Research on Leishmaniasis Studies
  • Pancreatic and Hepatic Oncology Research
  • Hepatitis B Virus Studies
  • Parasites and Host Interactions
  • Immunodeficiency and Autoimmune Disorders
  • Esophageal and GI Pathology
  • Pediatric health and respiratory diseases
  • Systemic Lupus Erythematosus Research
  • Mosquito-borne diseases and control
  • Medical Imaging and Pathology Studies
  • Metastasis and carcinoma case studies
  • Metabolism and Genetic Disorders
  • Hepatitis Viruses Studies and Epidemiology
  • Liver physiology and pathology
  • Magnetic and Electromagnetic Effects
  • Lung Cancer Diagnosis and Treatment
  • Gastric Cancer Management and Outcomes
  • Blood groups and transfusion
  • Global Maternal and Child Health
  • Pancreatitis Pathology and Treatment

The University of Tokyo
1973-2024

Nagasaki University Hospital
2022

Japan Community Healthcare Organization
2020

Harvard University
2019

Kyoto University
1966-2019

Shiga Medical Center
2014

Shiga Medical Center for Adults
2014

World Health Organization Regional Office for the Western Pacific
2012-2013

Ministry of Public Health and Social Assistance
2012

Shizuoka City Hospital
2009

Mesenchymal stem cells (MSCs) are recruited from BM to the stroma of developing tumors, where they serve as critical components tumor microenvironment by secreting growth factors, cytokines, and chemokines. The role MSCs in colorectal cancer (CRC) progression was controversial. In this study, we found that C-C chemokine receptor type 5 (CCR5) ligands (i.e., motif ligand 3 (CCL3), CCL4, CCL5) were highly produced using a array screening with conditioned media cultured human MSCs. A relatively...

10.1038/s41419-019-1508-2 article EN cc-by Cell Death and Disease 2019-03-19
Koji Amano Isseki Maeda Hiroto Ishiki Tomofumi Miura Yutaka Hatano and 95 more Hiroaki Tsukuura Tomohiko Taniyama Yoshihisa Matsumoto Yosuke Matsuda Hiroyuki Kohara Tatsuya Morita Masanori Mori Satoshi Inoue Naosuke Yokomichi Kengo Imai Toshihiro Yamauchi Akemi Shirado Naito Yu Uneno Akira Yoshioka Shuji Hiramoto Ayako Kikuchi Tetsuo Hori Hiromi Funaki Keiko Tanaka Kozue Suzuki Tina Kamei Yukari Azuma Teruaki Uno Jiro Miyamoto Hirofumi Katayama Hideyuki Kashiwagi Eri Matsumoto Kiyofumi Oya Takeya Yamaguchi Tomonao Okamura Hoshu Hashimoto Shunsuke Kosugi Nao Ikuta Yaichiro Matsumoto Takashi Ohmori Takehiro Nakai Takashi Ikee Yuto Unoki Kazuki Kitade Shu Koito Nanao Ishibashi Masaya Ehara Kosuke Kuwahara Shohei Ueno Shunsuke Nakashima Yuta Ishiyama Akihiro Sakashita Ryo Matsunuma Hana Takatsu Takashi Yamaguchi Satoko Ito Toru Terabayashi Jun Nakagawa Tetsuya Yamagiwa Akira Inoue Takuhiro Yamaguchi Mitsunori Miyashita Saran Yoshida Yusuke Hiratsuka Keita Tagami Hiroaki Watanabe Takuya Odagiri Tetsuya Ito Masayuki Ikenaga Keiji Shimizu Akira Hayakawa Rena Kamura Takeru Okoshi Tomohiro Nishi Kazuhiro Kosugi Yasuhiro Shibata Takayuki Hisanaga Takahiro Higashibata Ritsuko Yabuki Shingo Hagiwara Miho Shimokawa Satoshi Miyaké Junko Nozato Tetsuji Iriyama Keisuke Kaneishi Mika Baba Ayumi Okizaki Yuki Watanabe Yuko Uehara Eriko Satomi Kaoru Nishijima Junichi Shimoinaba Ryoichi Nakahori Takeshi Hirohashi Jun Hamano Natsuki Kawashima Takashi Kawaguchi Megumi Uchida Ko Sato Yoichi Matsuda

10.1016/j.clnu.2020.07.027 article EN Clinical Nutrition 2020-07-31

The water vaporization rate, an essential process for all the biological processes, was found to be significantly influenced under static magnetic fields up 8 T in air and oxygen. magnitude of effect depended on field–field gradient product B⋅dB/dx rather than B itself. Under forced flow conditions atmosphere, both enhancement suppression rate were observed depending upon direction gas relative field gradient. A mechanism is proposed explain results a systematic manner based assumption...

10.1063/1.371144 article EN Journal of Applied Physics 1999-09-01

As a vector control program to Chagas disease in Guatemala, residual spraying of Rhodnius prolixus and Triatoma dimidiata was performed, its impact measured the department Zacapa. In order identify infested villages determine degree infestation, baseline entomological survey municipalities with vectors followed by an additional areas known be conducted. Residual using pyrethroid insecticides performed at all identified as being vectors. The shown highly effective against both decrease...

10.1590/s0074-02762003000200019 article EN Memórias do Instituto Oswaldo Cruz 2003-03-01

Serum levels of monoamine oxidase (SMO) have been determined in 16 normal adults, 76 patients with hepatic diseases and 44 non-hepatic diseases. Elevated enzyme were found cirrhosis those chronic hepatitis or liver cancer associated moderate advanced fibrosis. It was also observed that SMO increased gradually progression The concentration could not be ascribed to hepatocellular necrosis cholestasis. In diseases, elevated the acromegaly, hyperthyroidism prooxidase gressive systemic sclerosis,...

10.1159/000197095 article EN Digestion 1971-01-01

To examine the existence of a possible threshold for domestic infestation rate Triatoma dimidiata , below which transmission becomes unlikely, census was conducted in 59 Chagas disease endemic communities El Salvador and Honduras. Entomological serological tests were targeting 4,083 households 6,324 children between 6 months 15 years age. The overall seroprevalence among 12.9% 0.49%, respectively. Communities with at 8% or less consistently showed 0%. In above 8%, there wide range...

10.4269/ajtmh.2012.11-0652 article EN American Journal of Tropical Medicine and Hygiene 2012-06-01

10.1016/j.jpainsymman.2020.11.037 article EN publisher-specific-oa Journal of Pain and Symptom Management 2020-12-05

In 2000, a national control operation against the triatomine vectors of Trypanosoma cruzi, based on house spraying with residual pyrethroid insecticides, was initiated in Guatemala. The impact Triatoma dimidiata most heavily infested department, Jutiapa, evaluated by pre- and post-spraying surveys vector populations. Of houses checked for Tri. baseline surveys, 18.3% were found to be bug, 12.1% villages investigated more than half infested. later survey conducted after 24,250 their...

10.1179/000349803235001895 article EN Annals of Tropical Medicine and Parasitology 2003-04-01

In 2000, the Guatemalan Ministry of Health initiated a Chagas disease program to control Rhodnius prolixus and Triatoma dimidiata by periodic house spraying with pyrethroid insecticides characterize infestation patterns analyze contribution programmatic practices these patterns. Spatial at three time points were identified using Getis-Ord Gi*( d ) test. Logistic regression was used assess predictors reinfestation after insecticide administration. analysis showed high low clusters points....

10.4269/ajtmh.2012.11-0052 article EN American Journal of Tropical Medicine and Hygiene 2012-03-01

In Guatemala, the Ministry of Health (MoH) began a vector control project with Japanese cooperation in 2000 to reduce risk Chagas disease infection. Rhodnius prolixus is one principal vectors and targeted for elimination. The method consisted extensive residual insecticide spraying campaigns, followed by community-based surveillance selective respraying. Interventions nine endemic departments identified 317 villages R. 4,417 surveyed. Two cycles covered over 98% houses villages. Fourteen...

10.1590/s0074-02762012000700007 article EN cc-by Memórias do Instituto Oswaldo Cruz 2012-11-01

Several parasitological studies carried out in El Salvador between 2000-2012 showed a higher frequency of acute cases Chagas disease than that other Central American countries. There is an urgent need for improved surveillance and vector control programs the provinces where occurs throughout as whole.

10.1590/0074-0276140416 article EN cc-by Memórias do Instituto Oswaldo Cruz 2014-02-01

This study aims to describe the prevalence of raised blood pressure and situation management for among adult population in Vietnam. It also examine association between diversified socioeconomic behavioral factors awareness pressure. Data were obtained from STEPS survey conducted Vietnam 2015. Survey sample was nationally representative with a total 3,856 people aged 18–69 years old. The outcomes included control Multiple logistic regression used behavior risk outcome variables. overall 2015...

10.1155/2019/1219783 article EN cc-by International Journal of Hypertension 2019-12-01
Koji Amano Hiroto Ishiki Tomofumi Miura Isseki Maeda Yutaka Hatano and 95 more Shunsuke Oyamada Naosuke Yokomichi Keita Tagami Takuya Odagiri Tetsuya Ito Mika Baba Tatsuya Morita Masanori Mori Satoshi Inoue Kengo Imai Hiroaki Tsukuura Toshihiro Yamauchi Akemi Shirado Naito Yu Uneno Akira Yoshioka Shuji Hiramoto Ayako Kikuchi Tetsuo Hori Yosuke Matsuda Hiroyuki Kohara Hiromi Funaki Keiko Tanaka Kozue Suzuki Tina Kamei Yukari Azuma Teruaki Uno Jiro Miyamoto Hirofumi Katayama Hideyuki Kashiwagi Eri Matsumoto Kiyofumi Oya Takeya Yamaguchi Tomonao Okamura Hoshu Hashimoto Shunsuke Kosugi Nao Ikuta Yaichiro Matsumoto Takashi Ohmori Takehiro Nakai Takashi Ikee Yuto Unoki Kazuki Kitade Shu Koito Nanao Ishibashi Masaya Ehara Kosuke Kuwahara Shohei Ueno Shunsuke Nakashima Yuta Ishiyama Akihiro Sakashita Ryo Matsunuma Hana Takatsu Takashi Yamaguchi Satoko Ito Toru Terabayashi Jun Nakagawa Tetsuya Yamagiwa Akira Inoue Takuhiro Yamaguchi Mitsunori Miyashita Saran Yoshida Yusuke Hiratsuka Hiroaki Watanabe Masayuki Ikenaga Keiji Shimizu Akira Hayakawa Rena Kamura Takeru Okoshi Tomohiro Nishi Kazuhiro Kosugi Yasuhiro Shibata Takayuki Hisanaga Takahiro Higashibata Ritsuko Yabuki Shingo Hagiwara Miho Shimokawa Satoshi Miyaké Junko Nozato Tetsuji Iriyama Keisuke Kaneishi Yoshihisa Matsumoto Ayumi Okizaki Yuki Watanabe Yuko Uehara Eriko Satomi Kaoru Nishijima Junichi Shimoinaba Ryoichi Nakahori Takeshi Hirohashi Jun Hamano Natsuki Kawashima Takashi Kawaguchi Megumi Uchida Ko Sato Yoichi Matsuda

Background: Limited information is available on the relationship between C-reactive protein (CRP) levels and pain in advanced cancer. Objectives: To investigate serum of CRP subtypes pain. Design: A secondary cross-sectional analysis a prospective cohort study. Setting/Subjects: Patients with cancer admitted to 23 palliative care units Japan. Measurements: rated severity numerical rating scale (NRS) physicians evaluated integrated outcome (IPOS). Physicians assessed neuropathic breakthrough...

10.1089/pmr.2021.0004 article EN cc-by-nc Palliative Medicine Reports 2021-05-01

In an entomological study in 2002, the degree of domestic and peridomestic infestation with triatomine bugs geographical distribution such infestations were investigated north-central Guatemala. The survey team searched for triatomines houses constructed mud walls or thatched roofs, villages suspected being infested. level observed was lower than that seen same area eastern Guatemala, a preliminary survey, 3 years earlier. Most detected Triatoma dimidiata but even this species found <7%...

10.1179/136485905x29684 article EN Annals of Tropical Medicine and Parasitology 2005-03-24

El Salvador is regarded as a highly endemic country for Chagas disease, evidenced by the relatively high estimated positive serology rate Trypanosoma cruzi among blood donors. This study aimed to identify factors contributing this analyzing changes in T. seroprevalence.Secondary data were collected from 31 banks operated Ministry of Health, Red Cross, Institute Salvadoran Social Security, and Military Hospital. The analyzed determine number cases seropositivity, average prevalence...

10.3855/jidc.4035 article EN cc-by The Journal of Infection in Developing Countries 2014-08-12

Abstract The 2ν3 band of methyl fluoride has been measured with a high-resolution infrared spectrometer. following molecular constants are obtained: ν0=2081.382, B″=0.85172, B′=0.82955, (A″–A′)=0.01953, DJ″=1.95×10−6, DJ′=1.78×10−6, DJK″=1.47×10−5 (assumed), DJK′=1.93×10−5, and (DK″–DK′)=5.9×10−6cm−1. In addition, the hot (3ν←ν3) isotope 13CH3F have observed analyzed. cubic force constant k333 was also obtained from vibration-rotation constants.

10.1246/bcsj.46.3399 article EN Bulletin of the Chemical Society of Japan 1973-11-01
Sayaka Arakawa Koji Amano Shunsuke Oyamada Isseki Maeda Hiroto Ishiki and 95 more Tomofumi Miura Yutaka Hatano Akemi Shirado Naito Mamiko Sato Tetsuya Ito Kazuhiro Kosugi Satoshi Miyaké Tatsuya Morita Masanori Mori Satoshi Inoue Naosuke Yokomichi Kengo Imai Hiroaki Tsukuura Toshihiro Yamauchi Yu Uneno Akira Yoshioka Shuji Hiramoto Ayako Kikuchi Tetsuo Hori Yosuke Matsuda Hiroyuki Kohara Hiromi Funaki Keiko Tanaka Kozue Suzuki Tina Kamei Yukari Azuma Teruaki Uno Jiro Miyamoto Hirofumi Katayama Hideyuki Kashiwagi Eri Matsumoto Kiyofumi Oya Takeya Yamaguchi Tomonao Okamura Hoshu Hashimoto Shunsuke Kosugi Nao Ikuta Yaichiro Matsumoto Takashi Ohmori Takehiro Nakai Takashi Ikee Yuto Unoki Kazuki Kitade Shu Koito Nanao Ishibashi Masaya Ehara Kosuke Kuwahara Shohei Ueno Shunsuke Nakashima Yuta Ishiyama Akihiro Sakashita Ryo Matsunuma Hana Takatsu Takashi Yamaguchi Satoko Ito Toru Terabayashi Jun Nakagawa Tetsuya Yamagiwa Akira Inoue Takuhiro Yamaguchi Mitsunori Miyashita Saran Yoshida Yusuke Hiratsuka Keita Tagami Hiroaki Watanabe Takuya Odagiri Masayuki Ikenaga Keiji Shimizu Akira Hayakawa Rena Kamura Takeru Okoshi Tomohiro Nishi Yasuhiro Shibata Takayuki Hisanaga Takahiro Higashibata Ritsuko Yabuki Shingo Hagiwara Miho Shimokawa Junko Nozato Tetsuji Iriyama Keisuke Kaneishi Mika Baba Yoshihisa Matsumoto Ayumi Okizaki Yuki Watanabe Yuko Uehara Eriko Satomi Kaoru Nishijima Junichi Shimoinaba Ryoichi Nakahori Takeshi Hirohashi Jun Hamano Natsuki Kawashima Takashi Kawaguchi Megumi Uchida

10.1007/s00520-021-06293-8 article EN Supportive Care in Cancer 2021-06-10

諸種の甲状腺疾患々者のタンパク結合ヨウ素を放射化分析により測定した。イオン交換樹脂カラムを通過させた血清を, 酸水解および蒸留を行ない, 生じたヨウ素分子を水酸化カリウムに捕捉し, これを4×1012n/cm2・secの熱中性子束で15分間照射した。誘導された128Iをヨウ素の選択的酸化および還元を行なったのち, 四塩化炭素で抽出し, 硝酸銀で沈殿せしめた。この方法によりヨウ素の高収率を得, またヨウ素以外の放射性核種を除去し得た。本法により測定されたタンパク結合ヨウ素の値は, 比色法による値とほぼ同一であった。

10.3769/radioisotopes.16.14 article EN RADIOISOTOPES 1967-01-01

症例は53歳の男性で,2007年6月初旬より左上腹部から背部にかけての疼痛を認めたが放置,次第に疼痛が増強してきたため6月下旬に当院を受診した.腹部所見は板状硬で,腹部CTにて膵尾部の膿瘍状の所見,脾臓にも梗塞性病変を認めた.膿瘍形成を伴う急性膵炎の疑診にて同日緊急開腹術を施行した.腹腔内全体に膿性腹水を認め,膵尾部は硬結し脾臓・横行結腸脾彎曲部と一塊となっており腫瘍と考えられた.脾臓には梗塞巣がみられ,下極で膿瘍化し膿汁の流出を認めた.膵尾部腫瘍は後腹膜に広範囲に浸潤しており,根治手術は不可能であった.しかし,脾臓・横行結腸の切除が必要であったため,腫瘍に切り込む形で膵尾部・脾臓・結腸脾彎曲部を切除し,横行結腸人工肛門を造設した.膵病変は低分化型腺癌で横行結腸に浸潤しており,脾梗塞とあいまって脾膿瘍を形成したと考えられた.かかる症例は非常にまれであり若干の文献的考察を加えて報告する.

10.5833/jjgs.42.528 article JA cc-by-nc The Japanese Journal of Gastroenterological Surgery 2009-01-01
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