A5005708195- Virology and Viral Diseases
- Pain Management and Opioid Use
- Nutrition and Health in Aging
- Pharmacological Effects and Toxicity Studies
- Opioid Use Disorder Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
- Lung Cancer Research Studies
- Animal Virus Infections Studies
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Reproductive tract infections research
- Lung Cancer Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Head and Neck Cancer Studies
- Nitric Oxide and Endothelin Effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Renin-Angiotensin System Studies
- Health Education and Validation
- Pneumothorax, Barotrauma, Emphysema
National Cancer Center
2021-2024
Tokyo National Hospital
2017-2024
National Cancer Center Hospital East
2019-2024
The University of Tokyo
2016-2021
Kanto Central Hospital
2014-2016
Kawasaki Medical School
2001-2008
Okayama University
2005
Kobe University
2000
Aichi Prefectural Government
1996
Increased production of reactive oxygen species (ROS) in diabetes may be a common pathway linking diverse pathogenic mechanisms diabetic vascular complications, including nephropathy. Assessment the oxidative stress is therefore important for prediction and prevention complications. However, ROS remain unclear glomeruli. To identify source determine kidney, was induced with streptozotocin rats. After 6 wk, glomerular had increased rat as assessed by dihydroethidium-derived chemiluminescence....
Recent studies showed that angiotensin II type 1 receptor blocker (ARB) slows progression of chronic renal disease in patients with 2 diabetes, regardless changes blood pressure. We the imbalance nitric oxide (NO) and reactive oxygen species (ROS) due to endothelial NO synthase (eNOS) uncoupling contributed dysfunction diabetic nephropathy. The aim this study was determine effects ARB on uncoupled eNOS rat nephropathy.Diabetes induced Sprague-Dawley rats streptozotocin (65 mg/ kg body...
Obesity is a known risk and exacerbation factor for bronchial asthma. Leptin an adipokine secreted by adipocytes enhances energy consumption. Earlier studies have shown that leptin also activates inflammatory cells structural cells, including airway epithelial thereby exacerbating inflammation. However, little about leptin's effect on normal human lung fibroblasts (NHLFs), which are deeply involved in remodeling This study aimed to elucidate the direct of NHLFs. NHLFs were co-cultured with...
To determine the roles of peritubular capillary (PTC) loss and expression vascular endothelial growth factor (VEGF) its transcription factor, hypoxia-inducible factor-1 (HIF-1), in progression IgA nephropathy (IgAN), we analyzed VEGF HIF-1, number PTCs patients with variable severity IgAN.Renal biopsy specimens from IgAN (n = 23) were classified according to interstitial injury score: grade 0 (0%), 1 (1-25%), 2 (25-50%) 3 (50-100%). We examined immunohistochemical CD34, HIF-1alpha.VEGF was...
ABSTRACT Background and objective Talc pleurodesis is commonly performed to manage refractory pleural effusion or pneumothorax. It considered as a safe procedure long limited amount of large particle size talc used. However, acute respiratory distress syndrome (ARDS) rare but serious complication after pleurodesis. We sought determine the risk factors for development ARDS using talc. Methods retrospectively reviewed patients who underwent with OK‐432 at University Tokyo Hospital. Results...
Multimodal care for cancer cachexia is needed. This study examined factors associated with practicing multimodal among physicians and nurses engaging in care.This was a preplanned secondary analysis of survey investigating clinicians' perspectives on cachexia. Data were used. knowledge, skills, confidence obtained. Nine items evaluated. Participants divided into two groups as (above median value the nine items) or not. Comparisons made using Mann-Whitney U test chi-square test. Multiple...
Sodium butyrate (NaBt), one of the short chain fatty acids naturally formed in gastrointestinal tract, induces differentiation as well apoptosis numerous cell types. The objectives this study were to characterize effects NaBt on growth, cycle, and human renal carcinoma (RCC) cells, determine whether enhances Fas-mediated cytotoxicity these cells. reduced vitro growth rate RCC ACHN cells a time- dose-dependent manner. Treatment with 1 mM resulted G1 cycle arrest, accompanied by up-regulation...
Objectives The prognostic factors in patients with malignancy-related ascites (MA) have been poorly investigated. This study aimed to evaluate both the impact of MA on terminally ill cancer and those MA. Methods was a post hoc analysis multicentre, prospective cohort study. Patients advanced admitted palliative care units at 23 institutions aged≥18 years were enrolled between January December 2017. Overall survival (OS) compared according A multivariate conducted explore Results Of 1896...
Summary Secretory IgA (SIgA) is a well-known mucosal-surface molecule in first-line defense against extrinsic pathogens and antigens. Its immunomodulatory pathological roles have also been emphasized, but it unclear whether plays role lung diseases. In the present study, we aimed to determine distribution of idiopathic pulmonary fibrosis (IPF) lungs affects functions airway epithelial cells. We performed immunohistochemical analysis sections from patients with IPF found that mucus...
The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) with large cell neuroendocrine carcinoma (LCNEC) patients remains unclear. Thus, we performed a retrospective study to examine relationship between pretreatment NLR and clinical outcome in advanced LCNEC impact immune-related tumour microenvironment (TME).This included 63 who had received chemotherapy. We collected data investigated TME status (CD4, CD8, CD20 FOXP3).The overall survival low (<5) was significantly longer than...
Although opioids have been shown to be effective for cancer pain, opioid-induced adverse events (AEs) are common. To date, little is known about the differences in risks of AEs by opioid type. This study was performed compare prevalence across commonly used analgesic treatment Japan.This conducted as a preplanned secondary analysis multicenter prospective longitudinal inpatients with pain who received specialized palliative care relief. We assessed daily until termination follow-up. rated...