A5037570310- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Lung Cancer Research Studies
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Image Retrieval and Classification Techniques
- Gastrointestinal Tumor Research and Treatment
- Advanced Image and Video Retrieval Techniques
- Inflammatory Biomarkers in Disease Prognosis
Showa University
2021-2024
National Cancer Centre Japan
2021-2023
Showa University Hospital
2022
Fukushima Medical University
2017-2021
University of Aizu
2017
Showa University Northern Yokohama Hospital
2013-2016
Delayed postpolypectomy bleeding occurs more frequently after hot resection than cold resection.To elucidate the underlying mechanism, we performed a histological comparison of tissue and snare resections.This is prospective study, registered in University Hospital Medical Information Network (UMIN000020104).This study was conducted at Aizu Center, Fukushima University, Japan.Fifteen patients scheduled to undergo colorectal cancer were enrolled.On day before surgery, 2 mucosal resections...
Immune checkpoint inhibitors (ICIs) confer remarkable therapeutic benefits to patients with various cancers. However, many are non-responders or develop resistance following an initial response ICIs. There no reliable biomarkers predict the effect of Therefore, this study investigated clinical implications plasma levels soluble anti-programmed death-1 (sPD-1) in cancer treated In total, 22 (13 non-small-cell lung carcinoma, 8 gastric cancer, and 1 bladder cancer) were evaluated for sPD-1...
The neutrophil‑to‑lymphocyte ratio (NLR) has been reported to be an independent prognostic factor of unresectable advanced or metastatic colorectal cancer (uCRC). However, few studies have documented changes in NLR during chemotherapy. current study analyzed whether a change chemotherapy patients with uCRC could used as biomarker. present retrospective enrolled 71 who received first‑line for between April 2012 and 2019. exclusion criteria were follows: Acute infection systemic inflammatory...
Neuroendocrine carcinoma of the cervix (NECC) is a rare and highly aggressive tumor with no efficient treatment. We examined genetic features NECC identified potential therapeutic targets. A total 272 patients cervical cancer (25 NECC, 180 squamous cell carcinoma, 53 adenocarcinoma, 14 adenosquamous carcinoma) were enrolled. Somatic hotspot mutations in 50 cancer-related genes detected using Ion AmpliSeq Cancer Hotspot Panel v2. Human papillomavirus (HPV)-positivity was by polymerase chain...
Abstract Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlated with prognosis in locally advanced cervical cancer. Seventy patients diagnosed International Federation Obstetrics Gynecology (FIGO) stage III IVA cancer underwent radiotherapy or concurrent chemoradiotherapy at National Cancer Center Hospital between January 2008 December...
Background. Standard treatment of early gastric cancer (EGC) after endoscopic resection with risk factors nodal metastases and incomplete is controversial. We investigated optimal management for the patients potentially noncurative EGC resection. Methods. retrospectively examined clinicopathological data surgical outcomes all clinically solitary adenocarcinoma who underwent curative surgery a single peroral at Digestive Disease Center Showa University Northern Yokohama Hospital between April...
Immune checkpoint inhibitors (ICIs) are among the most notable advances in cancer immunotherapy; however, reliable biomarkers for efficacy of ICIs yet to be reported. Programmed death (PD)‑ligand 1 (L1)‑expressing CD14<sup>+</sup> monocytes associated with shorter overall survival (OS) time patients treated anti‑PD‑1 antibodies. The present study focused on classification into three subsets: Classical, intermediate and non‑classical. A total 44 different types monotherapy (pembrolizumab or...
Lymph node metastasis (LNM) is a well-established prognostic factor in endometrial cancer (EC). We aimed to construct model that predicts LNM and prognosis using preoperative factors such as myometrial invasion (MI), enlarged lymph nodes (LNs), histological grade determined by biopsy, serum antigen 125 (CA125) level two independent cohorts consisting of 254 EC patients. The area under the receiver operating characteristic curve (AUC) constructed was 0.80 regardless machine learning...
Abstract Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare genetic backgrounds and their effect on clinical outcomes between Japanese Caucasian patients with ASCC. Forty-one diagnosed ASCC at National Cancer Center Hospital were enrolled evaluated for clinicopathological features, human papillomavirus (HPV) infection, HPV genotypes, p16 expression, PD-L1, association status efficacy concurrent chemoradiotherapy (CCRT). Target sequencing...
Abstract The rupture of a nonparasitic hepatic cyst with biliary communication is rare. We report the case patient that spontaneously ruptured and was successfully treated by laparoscopic deroofing closure communication. A 61‐year‐old woman presented at our hospital chief complaint right upper abdominal pain. Enhanced CT showed collapsed fluid collection. Drip infusion cholangiography contrast medium pooling in cyst. Therefore, diagnosed, were performed. postoperative course uneventful,...
AT-rich interactive domain 1A (ARID1A), which is a tumor suppressor gene, frequently mutated in Epstein-Barr virus-positive gastric cancer [EBV (+) GC]. While most ARID1A mutations GC are truncating mutations, leading to loss of protein expression, epigenetic modifications appear contribute deficiency EBV harboring wild-type ARID1A. Based on the significant role that contributes deficiency, methylation status was evaluated EBV-infected cells and patients using publicly available microarray...
Abstract Somatic genetic alteration analysis was performed for post-hysterectomy high-risk early-stage uterine cervical cancer patients who underwent post-operative radiation therapy. Post-operative therapy with pathological features of pelvic lymph node metastasis, parametrium invasion, or positive vaginal margin, which corresponded to the category. DNA extracted from paraffin-embedded surgical specimens, and 50 somatic hotspot alternations were detected using Ion AmpliSeq Cancer Hotspot...
ALK, ROS1 and NTRK fusions are involved in the tumorigenesis of various organs, including colorectal cancer. This study aims to clarify prevalence these cancer Japanese population. Immunohistochemical analysis 1012 specimens revealed two NTRK‐positive cases (0.2%) whereas no ALK‐ or ROS1‐positive were identified. Reverse transcription polymerase chain reaction (RT‐PCR) detected an LMNA‐NTRK1 fusion a case adenosquamous carcinoma TPM3 ‐ NTRK1 tubular adenocarcinoma. Both fusion‐positive...
To identify prognostic factors in patients with grade 3 (high-grade) endometrial endometrioid carcinoma, we evaluated the spectrum of genomic alterations and examined whether previously reported molecular subtypes carcinoma were adapted to clinical outcome prediction. Seventy-five Japanese who underwent a potentially curative resection procedure between 1997 2018 at National Cancer Center Hospital, included. We classified into four risk groups disease based on Proactive Molecular Risk...