A5026404831- Esophageal Cancer Research and Treatment
- Palliative Care and End-of-Life Issues
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Nutrition and Health in Aging
- Head and Neck Cancer Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Dysphagia Assessment and Management
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related gene regulation
- Oral health in cancer treatment
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Patient Dignity and Privacy
- Advanced Breast Cancer Therapies
- Bone and Joint Diseases
Fukuoka University
2024
Tokyo Medical and Dental University
2001-2023
Tsuchiura Kyodo General Hospital
2023
Tokyo Medical and Dental University Hospital
2020-2022
Weatherford College
2020
Japan Anti Tuberculosis Association
2020
Japan Association for Development of Community Medicine
2017
Tokushima Hospital
2014
Fukuoka Tokushukai Hospital
2011-2012
Hiratsuka City Hospital
2011
Abstract The significance of drinking green tea in prevention two the main lifestyle‐related diseases, cancer and cardiovascular disease, was demonstrated terms a prospective cohort study on total 8,552 general residents Saitama Prefecture, Japan. On basis follow‐up study, we revealed decreased relative risk incidence for those consuming over 10 cups day, compared with below 3 cups: 0.54 (95% men, 0.57 (0.34–0.98) women, 0.59 (0.35–0.98) both sexes. Furthermore, significant delay onset...
The retinoblastoma tumor suppressor protein (pRB) can inhibit cell cycle progression and promote differentiation. pRB interacts with a variety of transcription factors, including members the E2F C-EBP families MyoD, either repress or activate depending on promoter under study. These biological biochemical activities have been mapped previously to core domain, referred as pocket. Using panel synthetic pocket mutants, we found that acute induction G 1 /S block by is linked its ability both...
Background High levels of periodontopathic bacteria as well Streptococcus anginosus were detected in cancer tissue from patients with esophageal cancer. An association between oral infectious and has been reported. Methods Characteristics the microbiota periodontal conditions studied clinicopathologic factors The study included 61 62 matched individuals without any cancers. Samples subgingival dental plaque unstimulated saliva collected to evaluate prevalence abundance following using a...
Introduction Clinical sequencing has provided molecular and therapeutic insights into the field of clinical oncology. However, despite its significance, utility in Japanese patients remains unknown. Here, we examined tissue-based with FoundationOne ® CDx Heme. Between August 2018 2019, 130 pretreated advanced solid tumors were tested or Results The median age was 60.5 years (range: 3 to 84 years), among them, 64 males 66 females. Major cancer types gastrointestinal (23 cases) hepatic,...
The DNMT3A (DNA methyltransferase 3A) and DNMT3B genes encode putative de novo methyltransferases show complex transcriptional regulation in the presence of three two different promoters respectively. All lack typical TATA sequences adjacent to their transcription start sites contain several Sp1-binding sites. importance these was demonstrated by using a GC-rich DNA-binding protein inhibitor, mithramycin A, i.e. on basis decrease promoter activities mRNA expression levels DNMT3B....
<h3>Objectives</h3> Spinal cord stimulation is a potential therapeutic option for the treatment of Parkinson9s disease (PD)-associated symptoms. Repetitive trans-spinal magnetic (rTSMS) non-invasive and safe alternative spinal pathways that has not been studied efficacy in PD. We assessed benefits rTSMS on camptocormia, an often treatment-resistant postural abnormality observed PD patients. <h3>Methods</h3> compared to sham patients with camptocormia single-centre, randomised, single-blind,...
Patients with terminal cancer undergoing multidisciplinary palliative care often have oral health problems, but these details are still unclear. This cross-sectional study aimed to elucidate the of patients terminal-stage who inpatient recipients acute-phase care, and unveil factors affecting their health.Participants were 121 (68 males, 53 females, mean age: 73.6 ± 11.1 years) complaints. They received at Tokyo Medical Dental University Hospital between April 2017 August 2019. Their...
Comprehensive genomic profiling (CGP) provides information regarding cancer-related genetic aberrations. However, its clinical utility in recurrent/metastatic head and neck cancer (R/M HNC) remains unknown. Additionally, predictive biomarkers for immune checkpoint inhibitors (ICIs) should be fully elucidated because of their low response rate. Here, we analyzed the CGP identified that respond to ICIs R/M HNC. We evaluated over 1100 cases HNC using nationwide database established by Center...
Lymph node metastasis is a major prognostic factor for esophageal squamous cell carcinoma (ESCC). In recent years, endoscopic mucosal resection (EMR) has been developed with excellent results the treatment of superficial ESCC. To make EMR successful, it important to establish good indicator identify ESCC patients at high risk lymph metastasis. this study, we examined clinicopathological and immunohistochemical factors investigate involved in invading submucosal layer (sm‐ESCC). Surgical...
This study aimed to examine the status of undergraduate palliative care education among Japanese medical students using data from a survey conducted in 2015.A questionnaire was originally developed, and forms were sent universities. The study's objectives, methods, disclosure results, anonymity explained participating universities writing. Responses returned by considered indicate consent participate. Descriptive statistical methodology employed.The response rate 82.5% (66 80 faculties...
Smad proteins play key roles in intracellular signaling of the transforming growth factor-β (TGF-β) superfamily. E1A, an adenoviral oncoprotein, is known to inhibit TGF-β-induced transactivation through binding proteins. Recently, EID-1 (E1A-like inhibitor differentiation-1) and EID-2 (EID-1-like differentiation-2) were identified. In this study, we examined effect on Smad-mediated TGF-β signaling. Here, show that inhibits TGF-β/Smad transcriptional responses. interacts constitutively with...
As the life expectancy of cancer-bearing patients has increased, more with bone metastasis are receiving long-term treatment bone-modifying agents (BMAs; e.g., zoledronate and denosumab), which a risk factor for developing atypical femoral fracture (AFF). In this study, we surveyed iatrogenic AFF using clinical database on in past 10 years. From April 2011 through October 2019, 721 (436 men, 285 women; mean age, 65.7 ± 12.4 years) were registered under consultation system, been run by...
Background: Limited information is available on the relationship between C-reactive protein (CRP) levels and pain in advanced cancer. Objectives: To investigate serum of CRP subtypes pain. Design: A secondary cross-sectional analysis a prospective cohort study. Setting/Subjects: Patients with cancer admitted to 23 palliative care units Japan. Measurements: rated severity numerical rating scale (NRS) physicians evaluated integrated outcome (IPOS). Physicians assessed neuropathic breakthrough...
Abstract Purpose Maintenance of oral feeding is important in terms maintaining and improving the quality life terminal cancer patients receiving palliative care. Although adequate health status essential for hospitalized patients, relationship between care remains unclear. This cross-sectional study aimed to examine how general condition these relate decisions regarding their nutritional intake methods. Methods retrospective included 103 (59 men 44 women; mean age, 73.8 ± 10.9 years) who...