A5054954376- DNA Repair Mechanisms
- Cancer Treatment and Pharmacology
- Management of metastatic bone disease
- Breast Cancer Treatment Studies
- Conducting polymers and applications
- Cell death mechanisms and regulation
- Cancer Diagnosis and Treatment
- Bone health and treatments
- Cell Adhesion Molecules Research
- Advanced Thermoelectric Materials and Devices
- Plant Genetic and Mutation Studies
- Advanced Sensor and Energy Harvesting Materials
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- dental development and anomalies
- Esophageal Cancer Research and Treatment
- Endodontics and Root Canal Treatments
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Dental Health and Care Utilization
- Retinal Development and Disorders
- Carcinogens and Genotoxicity Assessment
- Dental Radiography and Imaging
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
University of Tsukuba
2019-2021
Tokyo Medical and Dental University
1967-2020
Toranomon Hospital
2017-2019
Tokai University
2017-2019
Hiratsuka City Hospital
2019
Nihon University
2008-2016
National Institutes for Quantum Science and Technology
2010-2016
National Institute of Technology, Hakodate College
2016
Fukushima Medical University
2014-2015
Japan Atomic Energy Agency
2013
Background High levels of periodontopathic bacteria as well Streptococcus anginosus were detected in cancer tissue from patients with esophageal cancer. An association between oral infectious and has been reported. Methods Characteristics the microbiota periodontal conditions studied clinicopathologic factors The study included 61 62 matched individuals without any cancers. Samples subgingival dental plaque unstimulated saliva collected to evaluate prevalence abundance following using a...
Abstract Aim To investigate differences in the root canal morphology of permanent mandibular molar teeth at various ages. Methodology Four hundred and eighty first second molars were examined. First divided into six five groups, respectively, according to age patient time extraction. Root was studied using a clearing technique. The mesial classified three stages depending on its developmental pattern. When system completely differentiated, classification number lateral canals inter‐canal...
The effects of the type electrolyte and film thickness on structural thermoelectric properties poly(3,4-ethylenedioxythiophene) (PEDOT) thin films indium-tin-oxide (ITO) substrates prepared using electropolymerization were investigated. Two electrolytes two different solvents: a water/methanol solvent (protic solvent) acetonitrile (aprotic with 3,4-ethylenedioxythiophene (EDOT) LiCF3SO3, typically included in as dopants. electrochemical analyzed; it was found that polymerization process for...
Abstract Hsp90 inhibitors have become well‐studied antitumor agents for their selective property against tumors versus normal cells. The combined treatment of inhibitor and conventional photon radiation also showed more effective tumor growth delay than alone. However, little is known regarding the heavy‐ion irradiation. In this study, SQ 5 human lung cells were used in vitro clonogenic cell survival vivo measurement using a mouse xenograft model after 17‐allylamino‐17‐demethoxygeldanamycin...
We investigated the effect of SCF, a c-kit ligand, on radiosensitivity HL60 cells. X-ray-induced apoptosis in cells was significantly lower presence SCF than absence SCF. This attenuation by abolished PD98059 (an ERK inhibitor), but not wortmannin (a PI3-K inhibitor) or GF109203X PKC inhibitor). The expression phospho-ERK1/2 (active form) and ERK1/2-regulated survivin were found to increase treated with X irradiation However, alone induced down-regulation phospho-ERK1/2. Our findings suggest...
To obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these with X-rays carbon beam.Human monolayer-type were maintained normal medium 10% bovine serum. In order to sphere-type the was replaced serum-free supplemented growth factors. Both types irradiated either or ion beams their evaluated.Serum-free induced expression proteins along neurosphere-like appearance. These found resistant both beams. Phosphorylation histone H2A family...
Aplyronine A (ApA) is an antitumor marine macrolide that induces protein-protein interaction (PPI) between actin and tubulin. The C1-C9 macrolactone part including the C7 N,N,O-trimethylserine (TMSer) ester important for its highly potent activities. To develop new PPI inducers, four aplyronine analogues were synthesized, which bear with 0-2 TMSer ester(s) C24-C34 actin-binding side chain. Despite exhibiting actin-depolymerizing activity comparable to of ApA, these did not show cytotoxicity...
Abstract A modified sensory “inching” method for the electrodiagnosis of carpal tunnel syndrome (CTS) Is described. The median nerve as stimulated at cubital portion, with 8 channel recording electrodes placed along across tunnel. In most CTS cases, there was a conductive abnormality from 3 to 4.5 cm distal proximal ending flexor retinaculum. Subjects'; values, obtained by subtracting theoretical latency measured latency, which were more than 0.6 ms, could not be improved conservative...
This cross-sectional study performed to clarify the relationship between periodontal disease and non-communicable diseases (NCDs), such as obesity, diabetes mellitus, impaired glucose tolerance (IGT), chronic obstructive pulmonary (COPD), atherosclerotic cardiovascular (ASCVD) by introducing dental examinations into annual health conducted Japanese companies, highlights importance of a medical system that connects professionals.A total 1.022 Hitachi Ltd. employees were enrolled in this...
We developed versatile actin-affinity tags from the side-chain analogs of aplyronine A, an antitumor marine macrolide.
Abstract An amphiphilic α ‐phenyl‐ N‐ ( tert ‐butyl) nitrone (PBN) derivative, N ‐{[4‐(lactobionamido)methyl]benzylidene}‐1,1‐dimethyl‐2‐(octylsulfanyl)ethylamine ‐oxide (LPBNSH), newly synthesized from its original form PBN in hopes of clinical use, was intraperitoneally administered to Long–Evans Cinnamon (LEC) rats every 2 days at the concentrations 0.1, 0.5, 1.0, and 2.0 mg/kg. We found that LPBNSH protected against copper‐induced hepatitis with jaundice LEC 0.1 0.5 mg/kg, which were...
Our previous study showed that X irradiation induced the expression of death receptor DR5 on cell surface in tumor lines under not only normoxia but also hypoxia. combined with TNF α-related apoptosis-inducing ligand (TRAIL), which is DR5, apoptosis vitro (Takahashi et al., (2007) Journal Radiation Research, 48: 461-468). In this report, we examined vivo antitumor efficacy TRAIL treatment xenograft models derived from human gastric adenocarcinoma MKN45 and MKN28 cells SCID mice....
High-purity hexagonal Sb2Te3 fine-platelets were successfully synthesized with high efficiency via a solvothermal route using precursor concentration the assistance of glucose. The synthesis was carried out at 180 °C for 16 h while solution stirred 500 rpm. To clarify role chemical compounds, we replaced glucose in polyvinyl pyrrolidone (PVP). Hexagonal platelets size 3–6 μm and approximate thickness 0.25 obtained when an optimal amount (0.8 g) used, production reached 90%. In contrast,...
Our previous study showed that ionizing radiation induced the expression of death receptor DR5 on cell surface in tumor lines and TNF α-related apoptosis-inducing ligand TRAIL enhanced apoptotic pathway (Hamasu et al., (2005) Journal Radiation Research, 46:103-110). The present experiments were performed to examine whether treatment with killing cells exposed under hypoxia, since presence radioresistant hypoxic regions solid tumors is a serious problem therapy for tumors. When human lung...
In this study, we first investigated the expression of Jagged1 at compression sites during experimental tooth movement in rats vivo. We then assessed effects force on production from human periodontal ligament (hPDL) cells. Twelve 6-week old male Wistar were subjected to an orthodontic 10 g order induce mesial tipping upper molars for 7 days. Expression levels tartrate-resistant acid phosphatase and proteins alveolar bone determined by immunohistochemical analysis. Furthermore, using hPDL...
In this study, we first investigated the expression of wnt5a in tension sites during experimental tooth movement rats vivo. We then assessed effects on bone marker from human periodontal ligament (hPDL) cells. Twelve male 6-week old Wistar were subjected to an orthodontic force 10g order induce mesial tipping upper molars for 7 days. The levels proteins alveolar determined using immunohistochemical analysis. Furthermore, gene expressions alkaline phosphatase (ALP) and type I collagen (COL1)...
In this study, we attempted to clarify the influence of DNA repair genes RAD54 and KU70, components homologous recombination (HR) non-homologous end-joining (NHEJ) pathways, respectively, on apoptosis induced by 1 Gy (low-dose) 5 (high-dose) irradiation. All experiments were performed using chicken B-lymphocyte DT40 cells repair-deficient cell lines KU70(-/-), RAD54(-/-) KU70(-/-)/RAD54(-/-). Morphological changes detected fluorescence methods, sub-G(1) fraction activated caspases in...
Orthodontic anchor screws, which made from titanium are widely used as anchorage units in orthodontic treatment. However, there some problems, including dropout during treatment and the invasive nature of screw removal. An screw, main component is a bioabsorbable material therefore sought. We investigated biological evaluation prototype composed polyglycolic acid (PGA) hydroxyapatite (HAp). Five types PGA/HAp composites were examined. The HAp compound ratios by weight 0, 5, 10, 30 50 %....
Orthodontic root resorption(ORR)is an unavoidable pathological consequence of orthodontic tooth movement. Swinging the due to reciprocating movement tooth(jiggling)mayexacerbate ORR.However, little is known about mechanism how jiggling induces ORR. We herein investigated tumor necrosis factor(TNF)-α expression in odontoclasts resorbed roots by force vivo. Twenty-four eight-week old male Wistar rats were divided into four groups, a heavy group(HF:50g), optimal group(OP: 10g), group(JF:...