A5039472504- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Laser Applications in Dentistry and Medicine
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Dental Radiography and Imaging
- Dental Health and Care Utilization
- Endodontics and Root Canal Treatments
- Bone Tissue Engineering Materials
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Oral and gingival health research
- HIV/AIDS oral health manifestations
- dental development and anomalies
- Mesenchymal stem cell research
- Protease and Inhibitor Mechanisms
- Immune Response and Inflammation
- Bone and Dental Protein Studies
- Dental materials and restorations
- Diabetes and associated disorders
- Dental Trauma and Treatments
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Bone Metabolism and Diseases
Shanghai Institute for Science of Science
2025
Institute of Science Tokyo
2025
Tokyo Medical and Dental University
2015-2024
The University of Tokyo
2013-2024
Southern Tohoku General Hospital
2019-2024
Nayoro City General Hospital
2013-2023
Soka University
2021
Yokohama City University
2020
Tokyo Medical and Dental University Hospital
2010-2019
Kanagawa Dental University
2018
Abstract Laser irradiation has numerous favorable characteristics, such as ablation or vaporization, hemostasis, biostimulation (photobiomodulation) and microbial inhibition destruction, which induce various beneficial therapeutic effects biological responses. Therefore, the use of lasers is considered effective suitable for treating a variety inflammatory infectious oral conditions. The CO 2 , neodymium‐doped yttrium‐aluminium‐garnet (Nd: YAG ) diode have mainly been used periodontal...
Periodontitis results in the destruction of tooth-supporting periodontal tissues and does not have ability to heal spontaneously. Various approaches been introduced regenerate tissues; however, these limited efficacy for treating severe defects. Cytotherapies combine stem cell biology tissue engineering form a promising approach overcoming limitations. In this study, we isolated ligament (PDL)-derived cells from patients created sheets with "Cell Sheet Engineering Technology", using...
The efficacy of the local application recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted 253 adult patients with periodontitis. Modified Widman surgery performed, during which 200 µL investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 administered to 2- 3-walled vertical bone defects. Each dose showed significant...
The options for medical use of signaling molecules as stimulators tissue regeneration are currently limited. Preclinical evidence suggests that fibroblast growth factor (FGF)-2 can promote periodontal regeneration. This study aimed to clarify the activity FGF-2 in stimulating lost by periodontitis and evaluate safety such stimulation.
The aim of this study was to evaluate the effect surface roughness on initial attachment mouse osteoblast-like cells ceriastabilized zirconia/alumina nanocomposite (NANOZR) and yttria-stabilized zirconia (3Y-TZP) in comparison those pure titanium (Ti) alumina oxide (AO). Specimens with smooth rough surfaces were prepared by grinding diamond paper or sandblasting, respectively. For four substrates examined, number attached specimens significantly higher than that (p < 0.05). Integrin alpha(5)...
The microbial differences between peri-implantitis and periodontitis in the same subjects were examined using 16S rRNA gene clone library analysis real-time polymerase chain reaction.Subgingival plaque samples taken from deepest pockets of sites six subjects. prevalence bacteria was analysed a reaction.A total 333 different taxa identified 799 sequenced clones; 231 (69%) uncultivated phylotypes, which 75 novel. numbers bacterial at 192 148 respectively. composition more diverse when compared...
Delayed gingival wound healing is widely observed in periodontal patients with diabetes. However, the molecular mechanisms of impaired function fibroblasts diabetes remain unclear. The purpose this study was to investigate changes properties human (HGFs) under high-glucose conditions. Primary HGFs were isolated from healthy gingiva and cultured 5.5, 25, 50, 75 mM glucose for 72 h. In vitro healing, 5-ethynyl-2′-deoxyuridine (EdU), water-soluble tetrazolium salt (WST-8) assays performed...
Periodontal disease is one of the most common infectious diseases in adults and characterized by destruction tooth-supporting tissues. Mesenchymal stem cells (MSCs) comprise mesoderm-originating cell population, which has been studied used for therapy. However, because lower rate survival after MSC transplantation various models, paracrine functions MSCs have receiving increased attention as a regenerative mechanism. The aim this study was to investigate potential transplanted conditioned...
Peri-implantitis (PI) is an inflammatory disease which leads to the destruction of soft and hard tissues around osseointegrated implants. The subgingival microbiota appears be responsible for peri-implant lesions although complexity has been reported in PI, PI not identified.The purpose this study was identify subjects who have clinically healthy implants, periodontitis-affected teeth using 16S rRNA gene clone library analysis clarify microbial differences.Three participated study....
Abstract Increasing evidence indicates that periodontitis affects non-alcoholic fatty liver disease (NAFLD). We examined the relationship between periodontal bacterial infection and clinical/biochemical parameters in 52 NAFLD patients. Anti- Aggregatibacter actinomycetemcomitans ( Aa ) antibody titers correlated positively with visceral fat, fasting plasma insulin, HOMA-IR; negatively liver/spleen ratio. C57BL/6J mice (8-weeks-old) were given or saline (control) for 6 weeks, fed either...
ABSTRACT We investigated the efficacy, safety, and clinical significance of trafermin, a recombinant human fibroblast growth factor (rhFGF)-2, for periodontal regeneration in intrabony defects Phase III trials. Study A, multicenter, randomized, double-blind, placebo-controlled study, was conducted at 24 centers. Patients with periodontitis 4-mm 3-mm or deeper probing pocket depth defects, respectively, were included. A total 328 patients randomly assigned (2:1) to receive 0.3% rhFGF-2...
Background High levels of periodontopathic bacteria as well Streptococcus anginosus were detected in cancer tissue from patients with esophageal cancer. An association between oral infectious and has been reported. Methods Characteristics the microbiota periodontal conditions studied clinicopathologic factors The study included 61 62 matched individuals without any cancers. Samples subgingival dental plaque unstimulated saliva collected to evaluate prevalence abundance following using a...
Anandamide (AEA) exhibits anti‐inflammatory effects. However, its role in the periodontal field remains unknown. Here, we found that gingival crevicular fluid contained a detectable level of AEA. The cannabinoid receptors CB1 and CB2 were expressed by human fibroblasts (HGFs), markedly upregulated under pathological conditions. AEA significantly reduced production pro‐inflammatory mediators (IL‐6, IL‐8 MCP‐1) induced Porphyromonas gingivalis LPS HGFs, this effect was attenuated AM251...