A5019001104- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Dental Health and Care Utilization
- HIV/AIDS oral health manifestations
- Bone Metabolism and Diseases
- Immune Response and Inflammation
- Dental Radiography and Imaging
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Bone health and treatments
- Streptococcal Infections and Treatments
- Microbial infections and disease research
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
- Stability and Control of Uncertain Systems
- Temporomandibular Joint Disorders
- Oral and gingival health research
- Oral and Maxillofacial Pathology
- Laser Applications in Dentistry and Medicine
Kobe Children's Hospital
2025
Kyushu Dental University
2015-2024
Osaka University
2002-2024
Sanken Electric (Japan)
2022
Osaka Research Institute of Industrial Science and Technology
2021-2022
Honda (Japan)
2022
Nagasaki University
2021
Waseda University
2020
Indian Institute of Technology Bombay
2019
Yokohama Sakae Kyosai Hospital
2014
The options for medical use of signaling molecules as stimulators tissue regeneration are currently limited. Preclinical evidence suggests that fibroblast growth factor (FGF)-2 can promote periodontal regeneration. This study aimed to clarify the activity FGF-2 in stimulating lost by periodontitis and evaluate safety such stimulation.
Actinobacillus actinomycetemcomitans is a Gram-negative bacterium implicated in the pathology of localized juvenile periodontitis, condition involving rapid destruction alveolar bone. We have established that gentle extraction this saline releases proteinaceous fraction (which we termed surface-associated material [SAM] which has potent osteolytic activity murine calvarial bone resorption assay. Fractionation SAM now revealed associated with 62-kD protein. This bone-resorbing can be blocked...
Objective and Background Periodontitis is an inflammatory disorder of the supporting tissue teeth, which composed gingival soft tissue, cementum covering tooth root, alveolar bone periodontal ligament. The receptor activator nuclear factor kappa B ligand ( RANKL ) known to be essential for osteoclastogenesis. Recent clinical studies indicate that levels in crevicular fluid are increased while its decoy receptor, osteoprotegerin OPG ), decreased patients with periodontitis. Although sulcus...
Objective and Background Human periodontal ligament mesenchymal stem cells (hPDLMSCs) are reported to be responsible for homeostasis regeneration of tissue. Although hPDLMSCs commonly cultured in monolayers, monolayer cultures have been as inferior 3‐dimensional such spheroids, which spherical clusters formed by self‐assembly. The aim this study was examine the osteogenic phenotype spheroids hPDLMSCs, compared with hPDLMSC, vitro vivo. Material Methods Spheroids were using microwell chips...
Objective . Photodynamic therapy has been expanded for use in endodontic treatment. The aim of this study was to investigate the antimicrobial effects diode laser irradiation on pathogens periapical lesions using an vitro apical lesion model. Study Design Enterococcus faecalis 0.5% semisolid agar with a photosensitizer injected into area direct as well heat produced by viability microorganisms were analyzed. Results E. significantly reduced combination and irradiation. temperature caused...
Human periodontal ligament mesenchymal stem cells (hPDLMSCs) have been known that they play important roles in homeostasis and regeneration of tissues. Additionally, spheroids are superior to monolayer-cultured cells. We investigated the characteristics potential tissue co-cultured hPDLMSCs human umbilical vein endothelial (HUVECs) vitro vivo. Co-cultured were prepared with cell ratios hPDLMSCs: HUVECs = 1:1, 1:2, 2:1, using microwell chips. Real-time polymerase chain reaction (PCR)...
To investigate the interrelationships among concerns regarding dental visits, status of regular and periodontal health during coronavirus disease 2019 (COVID-19) pandemic.Continuous oral care visits are important for maintaining health. Due to possibility contracting COVID-19, individuals have been reluctant visit medical institutions. It is unclear how Japanese population has affected by interruption COVID-19 pandemic attendance at visits.This study included 199 office workers in one...
H igh titers of serum IgG2 reactive with Actinobacillus actinomycetemcomitans are present in early‐onset periodontitis (EOP) patients and it appears that anti‐ A. may be protective. Smoking is associated increased periodontal disease severity generalized (G‐EOP) patients, but not localized juvenile (LJP). Furthermore, smoking reduced levels black G‐EOP those LJP. Based on this selective effect smoking, we hypothesized would a reduction specific LJP patients. In addition, examined responses...
A study of the prevalence Parkinson's disease (PD) was conducted in a Japanese city 1992, and data compared with those similar performed 1980. On day, April 1, total 156 patients (46 males 110 females) were found to be living investigated area, which had population 132,315. The per 100,000 117.9 (72.8 159.1 females), incidence during period 1989 through 1992 15.0 year. age- sex-adjusted 99.5 103.9 1980, as calculated using 1990 standard. age-adjusted under 60 years age 55 lower than These...
summary Tooth loss and osteoporosis may share common aetiologic agents which influence the process of both diseases. The purpose this study was to evaluate relationship between bone mineral density (BMD) os calcis number remaining teeth, controlling known confounding factors. Among all 70‐year‐old inhabitants in Niigata City, Japan, 600 people were selected randomly order have approximately same each gender. We analysed 460 subjects. evaluated BMD using an ultrasound densitometer, then we...
Bone is a highly vascularized organ, thus angiogenesis vital process during bone remodeling. However, the role of vascular systems in remodeling not well recognized. Here we show that netrin‐4 inhibits osteoclast differentiation vitro and vivo. Co‐cultures marrow macrophages with endothelial cells markedly inhibited differentiation. Adding neutralizing antibody, or RNA interference against netrin‐4, restored Administration prevented loss an osteoporosis mouse model by decreasing number. We...
Resistance to chemotherapy (chemoresistance) is a serious problem in malignant mesothelioma, highly aggressive neoplasm. Gamma-tocotrienol (gamma-T3) can sensitize various cancerous cells chemotherapeutic agents by inhibiting pathways that lead treatment resistance. In this study, we investigated the modulating effect of tocotrienol-rich fraction (TRF) from rice bran, which abundant gamma-T3, on chemoresistance human MM H28 cells. TRF caused marked reduction viability dose-dependent manner,...
The objective of this study was to examine whether native low-density lipoprotein (LDL) induces foam cell formation by macrophages and the effect lipopolysaccharide (LPS) on LDL-induced in vitro. RAW 264.7 cells were cultured with LDL or high-density (HDL) presence LPS derived from Aggregatibacter actinomycetemcomitans. Foam determined staining Oil-red-O visualize cytoplasmic lipid droplet accumulation. expression LDL-receptor degree internalization FITC-conjugated examined...