A5000006911- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Gut microbiota and health
- Dental Health and Care Utilization
- Ocular Diseases and Behçet’s Syndrome
- Nicotinic Acetylcholine Receptors Study
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Infectious Encephalopathies and Encephalitis
- Hepatitis C virus research
- Salivary Gland Disorders and Functions
- Kawasaki Disease and Coronary Complications
- Periodontal Regeneration and Treatments
- Infectious Diseases and Tuberculosis
- Parvovirus B19 Infection Studies
- Respiratory viral infections research
- Liver Diseases and Immunity
- Connexins and lens biology
- Receptor Mechanisms and Signaling
- Advanced Glycation End Products research
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Barrier Structure and Function Studies
- Otitis Media and Relapsing Polychondritis
- Machine Learning and Data Classification
Osaka University
2007-2025
Kyushu University
2000-2021
Kyoto University
2021
ShinKokura Hospital
2005-2007
Tokyo Medical University
2003-2004
Periodontal infection induces systemic inflammation; therefore, aggravating diabetes. Orally administered periodontal pathogens may directly alter the gut microbiota. We orally treated obese db/db diabetes mice using Porphyromonas gingivalis (Pg). screened for Pg-specific peptides in intestinal fecal specimens and examined whether Pg localization influenced microbiota profile, turn altering levels of metabolites. evaluated deterioration fasting hyperglycemia was related to changes...
Abstract Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of wounds. This study aimed to investigate association between PISA high-sensitivity C-reactive protein (hs-CRP), systemic inflammation marker. included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes dyslipidemia) dental...
Aim: The objective of this study was to examine the efficacy and safety low dose long‐term interferon (IFN) therapy in aged patients with chronic hepatitis C genotype 1. Methods: IFN performed Shin‐Kokura Hospital on 44 60 or older C. All had high viral loads Three million units natural IFN‐α administered intramuscularly intrasubcutaneously, three times a week for years. A control group subjects not treated IFN, matched age, gender hepatic histology, formed. Results: Two showed sustained...
Periodontitis is a chronic inflammatory disease that destroys tooth-supporting periodontal tissue. Current regenerative therapies have unsatisfactory efficacy; therefore, tissue engineering might be established by developing new cell-based therapies. In this study, we evaluated the safety and efficacy of adipose tissue-derived multi-lineage progenitor cells (ADMPC) autologous transplantation for regeneration in humans. We conducted an open-label, single-arm exploratory phase I clinical study...
This cross-sectional study performed to clarify the relationship between periodontal disease and non-communicable diseases (NCDs), such as obesity, diabetes mellitus, impaired glucose tolerance (IGT), chronic obstructive pulmonary (COPD), atherosclerotic cardiovascular (ASCVD) by introducing dental examinations into annual health conducted Japanese companies, highlights importance of a medical system that connects professionals.A total 1.022 Hitachi Ltd. employees were enrolled in this...
Membrane TNF-alpha is a precursor form of soluble and exerts pro-inflammatory functions in cell-to-cell contact manner. We showed that membrane induced upon activation on the cell surface CD4+ T cells CD8+ cells. In patients with systemic lupus erythematosus (SLE), percentage TNF-alpha-bearing (41.5+/-12.3%) was significantly higher compared those healthy controls (26.7+/-3.9%) (p=0.007) or rheumatoid arthritis (29.8+/-15.4%) (p=0.038). from SLE displayed cytotoxic activity against L929 It...
By exploring the feasibility of medical imaging applicable to periodontal disease, we have designed a MapReduce-like deep learning model for severity assessment by estimating pocket depth from oral images. However, typically relies on supervised training with large annotated dataset, and data often faces an insufficiency in quantity variety. Furthermore, obtaining patient annotating such experts still remain challenge. To overcome data, propose random cropping GAN-based augmentation methods...
A 24-year-old woman was hospitalised because of haemolytic anaemia, proteinuria and positive antinuclear anti-ds-DNA antibodies. Six days after admission, she suddenly showed disturbance consciousness determined to be mild confusion together with difficulty speaking, inappropriate vocalisations impaired attention. No abnormal findings were found in cerebral spinal fluid. MRI the entire corpus callosum swollen, markedly hyperintense signals on T2-weighted imaging (figure 1A), fluid-attenuated...
Hyperglycemia in diabetes is closely associated with periodontal disease progression. This study aimed to investigate the effect of hyperglycemia on barrier function gingival epithelial cells as a cause hyperglycemia-exacerbated periodontitis mellitus.The abnormal expression adhesion molecules epithelium was compared between db/db and control mice. To effects interepithelial cell permeability, mRNA protein expressions were investigated using human line (epi 4 cells) presence either 5.5 mM...
Abstract Periodontal infection is thought to generate systemic inflammation, thus aggravating diabetes. Furthermore, orally administered periodontal pathogens may directly alter the gut microbiota. To elucidate this, using an obese db/db diabetes mice, treated with Porphyromonas gingivalis ( Pg ), we screened for -specific peptides in intestinal fecal specimens and examined whether localization affected microbiota profile altering metabolite levels. Finally, deterioration of fasting...
The aim of the present study was to assess efficacy prolonged interferon monotherapy following combination treatment. Seventy-six patients were enrolled. Of these, 7 withdrawn while undergoing treatment with combined ribavirin, and 12 remained positive for HCV-RNA at completion We studied 57 Japanese chronic hepatitis C due genotype 1b HCV a high viral load. These tested negative 24 weeks. After treatment, 29 group successively received interferon-alpha weeks, 28 in alone no medication. rate...
Behçet's disease is a multisystem inflammatory disorder with unknown etiology. It has been shown that the titer of plasma complement component 9 (C9) good indicator activity. Therefore, involvement C9 in pathogenesis suggested. We report case associated complete deficiency (C9D) carrying homozygous nonsense mutation at Arg-95 (R95X). The patient presented typical characteristics disease, such as uveitis, recurrent oral aphthae and genital ulcers, arthritis, suggesting does not play an...