A5057246164- Nutrition and Health in Aging
- Genetics, Aging, and Longevity in Model Organisms
- Nutritional Studies and Diet
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Diet and metabolism studies
- Dental Health and Care Utilization
- Aging and Gerontology Research
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Temporomandibular Joint Disorders
- Chronic Disease Management Strategies
- Dysphagia Assessment and Management
- Health and Well-being Studies
- Body Composition Measurement Techniques
- Mitochondrial Function and Pathology
- Migration, Aging, and Tourism Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- FOXO transcription factor regulation
- Lipoproteins and Cardiovascular Health
- Health, Environment, Cognitive Aging
Keio University Shonan Fujisawa
2022-2025
Keio University
2016-2025
Keio University Hospital
1999-2025
Toho University
2022
Hokkaido University
2016-2022
Adama (Israel)
2019
Tohoku Medical Megabank Organization
2019
Tohoku University
2019
Osaka University
2016
Kyushu University
2014
To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete genomes of 672 Japanese individuals ( http://www.giib.or.jp/mtsnp/index_e.html ). This allowed us to perform a phylogenetic analysis with pool 942 Asiatic sequences. New clades and subclades emerged from data. On basis this unequivocal classified 4713 Asian partial sequences, <10% ambiguity. Applying population phylogeographic methods, used these sequences shed light on controversial issue peopling...
<h2>Abstract</h2> To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Centenarians Study (TCS) and Japanese Semi-Supercentenarians (JSS) comprising 1554 individuals including 684 centenarians (semi-)supercentenarians, 167 pairs centenarian offspring spouses, 536 community-living very (85 to 99years). We z scores from multiple biomarkers describe haematopoiesis,...
Supercentenarians, people who have reached 110 y of age, are a great model healthy aging. Their characteristics delayed onset age-related diseases and compression morbidity imply that their immune system remains functional. Here we performed single-cell transcriptome analysis 61,202 peripheral blood mononuclear cells (PBMCs), derived from 7 supercentenarians 5 younger controls. We identified marked increase cytotoxic CD4 T (CD4 lymphocytes [CTLs]) as signature supercentenarians. Furthermore,...
The effects of salt reduction and adequate nutrition intake among older adults with physical frailty remain controversial. Therefore, the present study investigated whether association between daily blood pressure community-dwelling adults, including very old people, based on their status. This cross-sectional used data from SONIC study, a cohort collected 2010 2012. Daily was estimated brief self-administered diet history questionnaire. Participants were stratified by groups use...
Background. Centenarians are sometimes said to be representative of lifelong healthy aging. Whether they are, in fact, examples aging remains a subject debate. The existence heterogeneity functional status has been reported repeatedly previous studies centenarians. However, there is as yet no standardized classification system with which describe their phenotype.
Poor oral health and hygiene are increasingly recognized as major risk factors for pneumonia among the elderly. To identify modifiable health–related factors, we prospectively investigated associations between a constellation of behaviors incident in community-living very elderly (i.e., 85 years age or older). At baseline, 524 randomly selected seniors (228 men 296 women; mean age, 87.8 years) were examined status well medical assessment, including blood chemistry analysis, followed up...
Objective— Cardiovascular disease (CVD), the most common morbidity resulting from atherosclerosis, remains a frequent cause of death. Efforts to develop effective therapeutic strategies have focused on vascular inflammation as critical pathology driving atherosclerosis progression. Nonetheless, molecular mechanisms underlying this activity remain unclear. Here, we ask whether angiopoietin-like protein 2 (Angptl2), proinflammatory protein, contributes that promotes Approach and Results—...
Engagement in leisure activities has been claimed to be highly beneficial the elderly. Practicing such is supposed help older adults preserve cognitive function, physical and mental health, thus contribute successful aging. We used structural equation modeling (SEM) analyze impact of on these constructs a large sample Japanese (N = 809; age range 72–74). The model exhibited an excellent fit (CFI 1); engaging was positively associated with all three aging indicators. These findings...
Abstract Supercentenarians (those aged ≥110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related and highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36...
The present study examined sex and age differences in taste sensitivity among young adult, young-old old-old Japanese.Participants were divided into three groups comprising 477 men 519 women the group (aged 69-71 years), 449 500 79-81 35 adult 24-32 years). Recognition thresholds for four basic tastes measured using 1-mL whole mouth gustatory test, which solutions of tested five concentrations.Young adults showed significantly lower recognition than group, group. Among groups, males sour,...
Objectives To elucidate the independent relationship between masticatory and physical performance in community‐living oldest old people (mean age ± standard deviation 87.8 2.2, range 85–102). Design Cross‐sectional analysis . Setting University research center or home‐based examination. Participants Four hundred eighty‐nine individuals (219 men, 270 women) aged 85 older. Measurements Maximum occlusal force ( MOF ) was measured using an measuring device. Sociodemographic functional factors,...
The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. majority genes found thus far be associated with primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers remain discovered.
Summary Mitochondrial‐derived peptides ( MDP ) are encoded by functional short open reading frames in the mitochondrial DNA (mt ). These include humanin , and recently discovered frame of 12S rRNA ‐c MOTS ‐c). Although more research is needed, we suggest that m.1382A>C polymorphism located encoding mt which specific for Northeast Asian population, may be among putative biological mechanisms explaining high longevity Japanese people.
Induced pluripotent stem cell (iPSC) technology can be used to model human disorders, create cell-based models of diseases, including neurodegenerative and in establishing therapeutic strategies. To detect subtle cellular abnormalities associated with common late-onset disease iPSCs, valid control iPSCs derived from healthy donors free serious diseases are necessary. Here, we report the generation fibroblasts obtained immediately postmortem centenarian (106- 109-years-old) who were extremely...
An increasing number of studies in Western countries have shown that healthy dietary patterns may a protective effect against cognitive decline and dementia. However, information on this relationship among non-Western populations with different cultural settings is extremely limited. We aim to examine the between function older Japanese people.This cross-sectional study included 635 community-dwelling people aged 69-71 years who participated prospective cohort titled Septuagenarians,...
BackgroundCentenarians and supercentenarians with exceptional longevity are excellent models for research towards improvements of healthy life expectancy. Extensive regarding the maintenance reduction epigenetic age has provided insights into increasing longevity. To this end, we explored signatures reflecting hallmarks longevity, including avoidance age-related diseases cognitive functional decline.MethodsIn cross-sectional study, enrolled Japanese non-centenarians (eligible participants...
Aim This study examined the association between number of prescribed medications and falls among community‐dwelling older adults. Methods We conducted a geriatric comprehensive health‐checkup on adults aged 69–91 years who participated in Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. The final analysis this included 1,076 participants complete data. were divided into four groups based at baseline: 0, 1, 2–4, ≥5. At 3‐year follow‐up, asked whether they...