A5085912121- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Cancer Genomics and Diagnostics
- Healthcare Operations and Scheduling Optimization
- Biomedical Text Mining and Ontologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Statistical Methods in Clinical Trials
- Healthcare cost, quality, practices
- Genetic factors in colorectal cancer
- Radiation Dose and Imaging
- Colorectal Cancer Treatments and Studies
- Sinusitis and nasal conditions
- Respiratory and Cough-Related Research
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Rare Diseases
- Artificial Intelligence in Healthcare and Education
- BRCA gene mutations in cancer
- COVID-19 epidemiological studies
- demographic modeling and climate adaptation
- Healthcare Policy and Management
- Allergic Rhinitis and Sensitization
- Acute Myeloid Leukemia Research
- Complex Systems and Decision Making
Sema4 (United States)
2022-2024
General Electric (United States)
2014-2017
General Electric (Spain)
2014
Siemens Healthcare (United States)
2009-2013
University of Washington
2000-2005
GlaxoSmithKline (United States)
2005
Fukuoka Higashi Medical Center
2005
GlaxoSmithKline (India)
2004
Exponent (United States)
2003
Institute of Public Health Zadar
2002
ContextWarfarin is a commonly used anticoagulant that requires careful clinical management to balance the risks of overanticoagulation and bleeding with those underanticoagulation clotting. The principal enzyme involved in warfarin metabolism CYP2C9, 2 relatively common variant forms reduced activity have been identified, CYP2C9*2 CYP2C9*3. Patients these genetic variants shown require lower maintenance doses warfarin, but direct association between CYP2C9 genotype anticoagulation status or...
Chronic stress affects many Americans. Stress management programs may be prohibitively expensive or have limited access.This study aims to determine feasibility of an 8-week Internet-based program (ISM) based on mindfulness principles in reducing a 12-week, parallel, randomized, controlled trial.Participants were randomly allocated ISM, ISM plus online message board (ISM+), control groups. Perceived stress, mindfulness, self-transcendence, psychological well-being, vitality, and quality life...
The use of pharmacogenomics to individualize drug therapy offers the potential improve effectiveness, reduce adverse side effects, and provide cost-effective pharmaceutical care. However, combinations disease, drug, genetic test characteristics that will clinically useful economically feasible therapeutic interventions have not been clearly elucidated. purpose this paper was develop a framework for evaluating cost-effectiveness pharmacogenomic strategies help scientists better understand...
Background: The National Cancer Institute has published consensus guidelines for universal screening hereditary nonpolyposis colorectal cancer (HNPCC) in patients with newly diagnosed cancer. Objective: To determine the cost-effectiveness of compared standard care eligible and their siblings children. Design: Cost-effectiveness analysis. Data Sources: registry data, Creighton International Hereditary Colorectal Registry, Medicare claims records, literature. Target Population: Patients Time...
Objective The goal of this study was to define the haplotype structure cytochrome P450 (CYP) 2C9 gene in a European American population and evaluate associations between CYP2C9 haplotypes anticoagulation-related outcomes. Methods Genomic deoxyribonucleic acid from 192 patients stabilized on warfarin therapy resequenced across 60 kilobases genomic region, including all exons, dense sampling introns, approximately 10 5′-flanking 1.7 3′-untranslated region. Results A total 132 single nucleotide...
Background: A genetic test for a composite interleukin‐1 (IL‐1) genotype is being marketed to predict risk progression of periodontal disease. The objective this study was determine the clinical scenario required produce cost‐effective results with use IL‐1 testing identify high‐risk patients. Methods: disease simulation model developed using decision‐analytic techniques and 30‐year time frame. Results: Using different modeling scenarios, produced ranging from cost savings $830,140 52.8...
Ground-glass opacities (GGOs) appearing in computed tomography (CT) scans may indicate potential lung malignancy. Proper management of GGOs based on their features can prevent the development cancer. Electronic health records are rich sources information GGO nodules and granular features, but most valuable is embedded unstructured clinical notes.
7568 Background: Conference abstracts serve as pivotal sources for sharing initial clinical trial findings, and influencing decisions.Yet, concerns persist regarding the impact of unpublished conference on ultimate conclusions potential inconsistency in result reporting. We aim to assess feasibility large-scale analysis, examining consistency between results subsequent reporting published articles, specifically focusing treatment efficacy safety oncology trials using a large language model...
An agent-based model is used to simulate a developing region population, disease burden, health care infrastructure and estimate the impact of resource investment decisions on population costs. In this approach, primary agents are individual facilities, capturing characteristics, facility catchment diagnostic capacity strategies. Health represented by new hospital placement in selected jurisdictions. Impact outcomes simulated over time horizon up 20 years. Data visualization applied compare...
The American College of Radiology develops evidence-based practice guidelines to aid appropriate utilization radiological procedures. Panel members use expert opinion weight trade-offs and consensus methods rate appropriateness imaging tests. These ratings include an equivocal range, assigned when there is disagreement about a technology's the evidence base weak or for special circumstances. It not clear how merges with arrive at rating. Quantitative benefit-risk assessment (QBRA) may assist...
Although optimal sequencing of systemic therapy in cancer care is critical to achieving maximal clinical benefit, there a lack analysis treatment advanced non-small cell lung (aNSCLC) real-world settings.A retrospective cohort study 13,340 patients within the Mount Sinai Health System (MSHS) was performed. Systemic data aNSCLC 2,106 starting point our investigate how has evolved, impact patterns on outcomes, and effectiveness 2nd line chemotherapy after progressed immune checkpoint inhibitor...