A5100403769- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Neuroimaging Techniques and Applications
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Cancer Mechanisms and Therapy
- Selenium in Biological Systems
- Erythrocyte Function and Pathophysiology
- Global Cancer Incidence and Screening
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Sexual function and dysfunction studies
- Pelvic and Acetabular Injuries
- Retinal Imaging and Analysis
- Cardiac Imaging and Diagnostics
Hebei North University
2025
Jiamusi University
2022-2025
Harbin Medical University
2021-2025
Guiyang Medical University
2025
Xi'an Jiaotong University
2025
First Affiliated Hospital of Jiamusi University
2022-2025
Fourth Affiliated Hospital of Harbin Medical University
2024-2025
Chengdu University of Traditional Chinese Medicine
2025
National Cheng Kung University
2025
Children's Hospital of Chongqing Medical University
2021-2024
Abstract Although antiangiogenic therapy has been used in gastric cancer, disease progression due to drug resistance remains common. Neutrophils play an important role the occurrence and of cancer via neutrophil extracellular traps (NETs). However, few studies have investigated angiogenic regulation cancer. We aimed determine NETs promoting angiogenesis Multiple immunohistochemical staining was analyze spatial distribution microvessels patient tissue samples. A mouse subcutaneous tumor model...
Abstract Background Inflammation-related predisposition to cancer plays an essential role in progression and is associated with poor prognosis. A hypoxic microenvironment neutrophil infiltration are commonly present solid tumours, including gastric (GC). Neutrophil extracellular traps (NETs) have also been demonstrated the tumour immune (TIME), but how NETs affect GC remains unknown. Here, we investigated of NET formation TIME further explored underlying mechanism growth. Methods...
Abstract Novel boron‐containing carbon dots (BCDs) are designed and prepared for boron neutron capture therapy (BNCT) with superior water solubility excellent optical property tracking 10 B in vitro vivo. Encapsulation of BCDs using exosomes (Exos) from macrophages yields BCD–Exos ≈100 nm. Fluorescent imaging shows that the internalized distributed around nuclei U‐87‐MG glioma cells. also verified to cross blood–brain barrier significant accumulation tumor tissue orthotopic tumor‐bearing...
Ferroptosis is closely associated with the pathophysiology of myocardial ischemia. Hydroxysafflor yellow A (HSYA), main active ingredient in Chinese herbal medicine safflower, exerts significant protective effects against ischemia/reperfusion injury (MI/RI). The aim this study was to investigate HSYA MI/RI and identify putative underlying mechanisms. An vivo model acute established C57 mice. Subsequently, on tissue were evaluated by histology. Lipid peroxidation marker contents serum iron...
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become an increasingly important health challenge, with a substantial rise linked to changing lifestyles and global obesity. Ursolic acid, natural pentacyclic triterpenoid, been explored for its potential therapeutic effects. Given multifunctional bioactive properties, this research further revealed the pharmacological mechanisms of ursolic acid on MASLD. Drug target chips bioinformatics analysis were combined in study...
MRI allows brain anatomy to be examined at high resolution and link pathology measures with morphometric measurements. However, automated segmentation methods for mapping in postmortem are not well developed, primarily due limited availability of labeled datasets, heterogeneity scanner hardware acquisition protocols. In this work, we present a high-resolution dataset 135 human tissue specimens imaged 0.3 mm
Ulcerative colitis (UC) is a chronic and relapsing inflammatory bowel disorder in the colon rectum leading to low life-quality high societal costs. Ursolic acid (UA) natural product with pharmacological biological activities. The studies are aimed at investigating protective treatment effects of UA against dextran sulfate sodium- (DSS-) induced UC mouse model its underlying mechanism. was orally administered different time points before after DSS-induced model. Mice body weight, length,...
Selenium (Se) is an essential trace element known for its significant role in maintaining human health and mitigating disease progression. compounds exhibit high selective cytotoxicity against tumor cells. However, their anti-cervical cancer (CC) effects underlying mechanisms have not been fully explored. This study found that sodium selenite (SS) inhibits the viability of HeLa SiHa cells a dose- time-dependent manner. Intraperitoneal injection 3 6 mg/kg SS 14 days female nude mice...
Accurate prediction of the relative biological effectiveness (RBE) boron neutron capture therapy (BNCT) is challenging. The different from other radiotherapy; dynamic distribution boron-containing compounds in tumor cells affects therapeutic outcome considerably and hampers accurate measurement neutron-absorbed dose. Herein, we used metal-organic framework nanoparticles (BMOFs) with high content to target U87-MG maintain concentration 10B isotope cells. could 90% (60 ppm) within 20 min...
Phospholipids (PLs) are principle constituents of biofilms, with their fatty acyl chain composition significantly impacting the biophysical properties membranes, thereby influencing biological processes. Recent studies have elucidated that chains, under enzymatic action lyso‑phosphatidyl‑choline acyltransferases (LPCATs), expedite incorporation into sn‑2 site phosphatidyl‑choline (PC), profoundly affecting pathophysiology. Accumulating evidence suggests alterations in LPCAT activity...
The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential disease treatments. Clustered regularly interspaced short palindromic repeats (CRISPR) activator (CRISPRa) is a powerful tool that can conveniently efficiently activate expression multiple endogenous genes simultaneously, providing new strategy for cell fate determination. main purpose this study explore feasibility...
Programmed cell death ligand 1 (PD-L1) expression on immune cells is correlated with the efficacy of checkpoint inhibitor (ICI) therapy in various types cancer. Platelets are important components tumour microenvironment (TME) and widely involved development many cancer including colorectal (CRC). However, role PD-L1 positive platelets ICI for CRC remains unknown. We hypothesized that trigger sustain immunosuppression. The functional depletion effects TME were measured via western blotting,...
Abstract In mainland China, cancer registration relies on household‐registered populations, overlooking migrant populations. Estimating cervical incidence among permanent residents, including migrants, offers a more accurate representation of the true burden. The data from 487 registries across China in 2016 were analyzed using Bayesian spatial regression model with integrated nested Laplace approximation‐stochastic partial differential equation method. study estimated populations and...
Abstract Background Radiofrequency catheter ablation (RFCA) is a widely employed method for restoring sinus rhythm(SR) in patients with drug-refractory paroxysmal atrial fibrillation (PAF). Three-dimensional speckle tracking echocardiography (3DSTE) precise and practical imaging technique clinically assessing myocardial function the left atrium. The objective of this study was to assess alterations three-dimensional strains predict recurrence PAF following RFCA. Methods A total 109 diagnosed...
Abstract The limited depth of field optical microscopes typically results in the blurring all but a small portion image, making it difficult to assess height, shape, and surface profile samples. This issue can be partly resolved by capturing series images at various sample distances adjusting piezoelectric stage; however, scanning performance is prone perturbations resulting from nonlinear response characteristics. paper presents novel three-dimensional microscopic imaging system that uses...
We theoretically demonstrate that carbon nanoscrolls, spirally wrapped graphene layers with open end points, can be characterized by a large positive magnetoconductance. show when nanoscroll is subject to an axial magnetic field of several Tesla, the ballistic conductance at low carrier densities increases about 200%. Importantly, we find this magnetoconductance not only preserved in imperfect (with disorder or mild interturn misalignment) but even enhanced presence on-site disorder. prove...
Since 2020, the receptor-binding domain (RBD) of spike protein novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been constantly mutating, producing most notable missense mutations in context “variants concern”, probably response to vaccine-driven alteration immune profiles human population. The Delta variant, particular, become prevalent variant epidemic, and it is spreading countries with highest vaccination rates, causing world face risk a new wave contagion....
Background Neutrophil extracellular traps (NETs) are crucial in the progression of several cancers. The formation NETs is closely related to reactive oxygen species (ROS), and granule proteins involved nucleosome depolymerization under action ROS together with loosened DNA compose basic structure NETs. This study aims investigate specific mechanisms promoting gastric cancer metastasis order perfect existing immunotherapy strategies. Methods In this study, cells tumor tissues were detected by...