A5100419309- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Pediatric Hepatobiliary Diseases and Treatments
- Orthopedic Surgery and Rehabilitation
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Foot and Ankle Surgery
- RNA modifications and cancer
- Cervical and Thoracic Myelopathy
- Colorectal Cancer Surgical Treatments
- Neuroblastoma Research and Treatments
- Immune Response and Inflammation
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Bone and Joint Diseases
- Bone fractures and treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Changhai Hospital
2018-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Second Military Medical University
2011-2025
Hangzhou First People's Hospital
2024-2025
Westlake University
2024-2025
Affiliated Hospital of Qingdao University
2012-2024
Peking University Cancer Hospital
2011-2024
Inner Mongolia Medical University
2024
First Affiliated Hospital of Zhengzhou University
2024
Background Dietary management is considered a potential adjunctive treatment for inflammatory bowel disease (IBD). Short-video sharing platforms have enabled patients to obtain dietary advice more conveniently. However, accessing useful resources while avoiding misinformation not an easy task most patients. Objective This study aimed evaluate the quality of information in IBD diet–related videos on Chinese short-video platforms. Methods We collected and extracted from total 125 video samples...
To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year.Participants were drawn from Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have osteoarthritis or are at risk. The HIPAA-compliant protocol was approved by institutional review boards all participating centers, and written informed consent obtained participants. During...
Abstract Mitochondrial dysfunction contributes to the pathogenesis of ulcerative colitis (UC). As a mitochondrial isozyme creatine kinases, which control energy metabolism, CKMT1 is thought be critical molecule in biological processes. However, specific role intestinal inflammation remains largely unknown. Here, we observed markedly decreased expression colon tissues UC patients and dextran sodium sulfate (DSS)-induced mice. We generated epithelial-specific knockout mice demonstrated key...
Abstract Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intrinsic features, especially those that can be dynamically monitored via liquid biopsy, represent a broader scope biomarker development. In addition, potential mode of resistance tumor-intrinsic mechanisms leading to an immunosuppressive tumor...
Osteosarcoma (OS) has a high incidence, malignity, and frequency of recurrence metastasis. In this study, we aimed to explore the potential anti-cancer effects Astragalus polysaccharides (APS) on human OS MG63 cells as well underlying mechanisms. Viability was assessed by CCK-8 assay determine adequate concentration APS. Then, APS cell proliferation, cycle distribution, apoptosis, migration invasion were analyzed BrdU incorporation, PI staining, flow cytometry, transwell assays,...
Abstract Background and Aim Although studies have shown that the quality of bowel preparation with low‐residue diet (LRD) is as effective clear fluid (CLD), there currently no consensus on how long an LRD should last. The aim this study was to compare a 1‐day versus 3‐day before colonoscopy. Methods A systematic review search conducted in MEDLINE/PubMed, EMBASE, Web Science, Cochrane database from inception April 2023. We identified randomized controlled trials (RCTs) compared cleansing...
Abstract Background and Aim Endoscopic transmural drainage has been recognized as the first‐line treatment for pancreatic fluid collection (PFC). Currently, three different types of stents have extensively applied, including double pigtail plastic stent (PS), fully covered self‐expanding metal (FCSEMS), novel lumen‐apposing (LAMS). Nonetheless, limited data are available about comparison among them in terms their clinical outcomes safety endoscopic ultrasound‐guided PFC. Methods The current...
BACKGROUNDLateral lymph node metastasis is one of the leading causes local recurrence in patients with advanced mid or low rectal cancer.Neoadjuvant chemoradiotherapy (NCRT) can effectively reduce postoperative rate; thus, NCRT total mesorectal excision (TME) most widely accepted standard care for cancer.The addition lateral dissection (LLND) after remains a controversial topic. AIMTo investigate surgical outcomes TME plus LLND, and possible risk factors NCRT. METHODSThis retrospective study...
Abstract Recent studies have shown that high cell cycle activity negatively correlates with antitumor immunity in certain cancer types. However, a similar correlation has not been proven liver cancer. We downloaded transcriptomic profiles of the genome atlas‐liver hepatocellular carcinoma (TCGA‐LIHC) and assessed distribution samples using single sample gene set enrichment analysis (ssGSEA), termed score (CCS). obtained cycle‐related differentially expressed prognostic genes identified...
In the present study, proteins differentially expressed between gastric cancer tissue and para‑tumoral normal tissues were screened, function of highly protein C1QTNF6 in carcinoma was investigated. The differential expression mRNAs extracted from tumor adjacent analyzed using GeneChip assay. An AGS si‑C1QTNF6 cell line constructed shRNA‑C1QTNF6 lentivirus. invasion migration ability C1QTNF6‑knockdown cells determined by Transwell chamber wound healing assays, respectively. effects on cycle...
For laparoscopic rectal cancer surgery, the inferior mesenteric artery (IMA) can be ligated at its origin from aorta [high ligation (HL)] or distally to of left colic [low (LL)]. Whether different levels are related postoperative complications, operation time, and lymph node yield remains controversial. Therefore, we designed this study determine effects in surgery.
Homeotransplantation of bones for replacement therapy have been demonstrated reliably in clinical data. However, human donor applicable homeotransplantation are short supply, which facilitates the search suitable alternatives, such as xenografts grafts. The α-Gal antigen-related immune risk directly affects safety and effectiveness biomaterials limits their applications clinic. can be prevented by depletion or breaking anti-Gal antibody prior to transplant. Therefore, how assess bone...