A5100427833- Bacterial Identification and Susceptibility Testing
- Hematological disorders and diagnostics
- MicroRNA in disease regulation
- Biosensors and Analytical Detection
- Electrocatalysts for Energy Conversion
- Circular RNAs in diseases
- Streptococcal Infections and Treatments
- Advanced biosensing and bioanalysis techniques
- Orthopedic Infections and Treatments
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Antibiotic Resistance in Bacteria
- Advanced battery technologies research
- Neonatal and Maternal Infections
- Fuel Cells and Related Materials
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Molecular Sensors and Ion Detection
- Acute Kidney Injury Research
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
Capital Medical University
2012-2024
Chinese PLA General Hospital
2015-2024
Hebei University of Science and Technology
2023-2024
Chinese People's Liberation Army
2013-2024
Qingdao University of Science and Technology
2021-2024
Shanghai Tenth People's Hospital
2022-2024
Tongji University
2022-2024
Capital University
2024
Weifang Medical University
2023
Liuyang City Maternal and Child Health Hospital
2023
Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic fatty liver disease. The aim our study investigate role Sirtuin 3 (Sirt3) in treating disease with focus on mitophagy and ERK-CREB pathway. Our data indicated that Sirt3 was downregulated tissue response chronic HFD treatment. Interestingly, re-introduction protected hepatic function, attenuated fibrosis, alleviated inflammatory response, prevented hepatocyte apoptosis. Molecular investigations...
Abstract The rapid high-throughput detection of foodborne pathogens is essential in controlling food safety. In this study, a 10-channel up-converting phosphor technology-based lateral flow (TC-UPT-LF) assay was established for the and simultaneous 10 epidemic pathogens. Ten different single-target UPT-LF strips were developed integrated into one TC-UPT-LF disc with optimization. Without enrichment had sensitivity 4 CFU mL −1 or 5 each pathogen, after sample it CFU/0.6 mg. also showed good...
Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles ferroptosis via several mechanisms, including regulating iron metabolism, glutathione lipid peroxidation mitochondrial-related proteins, there many circRNAs need be found, they may become new molecular treatment target GBM.The expression levels circLRFN5, PRRX2 GCH1 were detected by qPCR, western blotting,...
Variable immune responses to hepatitis B virus (HBV) infection and recombinant HBV vaccines have been associated with polymorphisms in several genes within the human leukocyte antigen (HLA) complex. Analyses of polymerase chain reaction (PCR)-based genotyping data from 164 North American adolescents vaccinated products confirmed that HLA-DRB1*07 (relative odds [RO] = 5.18, P <.0001) immunodeficiency type 1 (HIV-1) (RO 3.91, <.001) were both nonresponse full-dose vaccination. Further...
Abstract Multifunctional electrocatalysts play an increasingly crucial role in various practical electrochemical energy conversion devices. Especially, on the air cathode of rechargeable zinc–air batteries (ZABs), oxygen reduction reaction (ORR) and evolution (OER), requiring efficient bifunctional electrocatalysts, are switched during discharging charging process. Here, supported by theoretical computations, a facile strategy for situ assembly NiFe‐MOFs nanosheets heteroatoms‐doped porous...
Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.The highly enriched glioblastoma (GBM) were obtained through analysis of sequencing datasets. Quantitative real-time PCR (qRT-PCR) was used to determine the expression circRNF10 normal brain tissue. Both gain-of-function loss-of-function studies assess effects on using vitro vivo assays. The hypothesis that ZBTB48...
Congenital cytomegalovirus (CMV) infection is the leading viral cause of birth defects and developmental disabilities in developed countries. However, CMV seroprevalence burden congenital are not well defined China. Cohort newborns from 5 birthing hospitals 2 counties Shandong Province, China, were enrolled March 2011 to August 2013. Dried blood spots (DBS) saliva collected within 4 days after for IgG testing maternal real-time PCR infection, respectively. Among 5020 tested IgG, 4827...
Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity colorectal cancer (CRC). miR-296 was found to play either oncogenic or tumor suppressive role human cancers. However, status its function CRC remain unknown. The expression confirmed by qRT-PCR tissues cells, level altered corresponding miRNA vectors. Wound healing Transwall assays were performed detect migration invasion cells. levels proteins measured using immunoblotting, immunohistochemistry...
Background: With the recent evolution of multidrug-resistant strains, genetic characteristics foodborne Salmonella enterica serovar Enteritidis and clinical isolates have changed. ST11 is now most common genotype associated with S. isolates. Methods: A total 83 strains were collected at General Hospital People’s Liberation Army. Of these, 37 from aseptic sites in patients, 11 feces patients diarrhea, remaining 35 chicken-origin. The minimum inhibitory concentration was determined by broth...
Aim. We aimed to investigate and evaluate the preventive activity of puerarin on ovalbumin-induced asthma rat model. Materials Methods. Male Wistar rats were sensitized intraperitoneally days 0, 7, 14 challenged ovalbumin intratracheally day 21. Groups treated randomly either with placebo, puerarin, dexamethasone, or combined from 15 20. Inflammatory markers, including cell counts in bronchoalveolar lavage fluid (BALF), inflammatory cytokines, histopathology, coagulation parameters, such as...
Breast cancer is the most common malignancy in women which increases gradually all over world. LncRNA GACAT3 has been found to be increased gastric and associated with tumor malignancy. However, whether plays a role regulation of breast not known. In presen t study, we that expression was tissues cells compared adjacent normal cells. High correlated poor prognosis patients. cyclin D2 (CCND2) contained binding site miR-497. miR-497 decreased Low tissues, negatively GACAT3. Downregulation...
Abstract Francisella tularensis is a potential biowarfare/bioterrorism agent and zoonotic pathogen that causes tularemia; thus, surveillance of F. first-level emergency response using point-of-care testing (POCT) are essential. The UPT-LF POCT assay was established to quantitatively detect within 15 min the sensitivity 10 4 CFU · mL −1 (100 CFU/test). linear quantitative range covered five orders magnitude coefficients variation were less than 10%. Except Shigella dysenteriae , showed...
The advent of cefiderocol provides hope for the clinical treatment multi-drug resistant gram-negative bacteria (GNB), especially those with carbapenem resistance. Resistance
In this study, we prepared self-quenching-resistant solid-state fluorescent carbon nanodots (SFCDs) without any other solid matrices. The SFCDs were using a one-step microwave synthesis method through precise control of the heating power and time. resulting SFCD powder showed excitation-dependent emission behavior with maximum fluorescence quantum yield 40%. multicolored successfully used as agents for rapid staining 14 representative bacterial species, including Gram-negative,...
Glioblastoma (GBM) is the most common primary malignant tumor in brain, and its robust proliferation invasion abilities reduce survival time of patients. Circular RNAs (circRNAs) play an essential role various tumors, such as regulating cell proliferation, apoptosis, invasion, metastasis, other progressive phenotypes through different mechanisms. Finding novel circRNAs may significantly contribute to prognosis GBM provide basis for targeted therapy GBM. In this study, we found circPTPRF a...