A5100616104- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Ferroptosis and cancer prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Blood transfusion and management
- Moyamoya disease diagnosis and treatment
- Pelvic and Acetabular Injuries
- Nuclear Receptors and Signaling
- Advanced MRI Techniques and Applications
- Immune cells in cancer
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and genetic disorders
- Estrogen and related hormone effects
- Galectins and Cancer Biology
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
Beijing Academy of Science and Technology
2019-2024
Ganzhou People's Hospital
2024
Beijing Administration Institute
2021
China Medical University
2020
Chinese PLA General Hospital
2019-2020
First Affiliated Hospital of Anhui Medical University
2020
Anhui Medical University
2020
Shandong Tumor Hospital
2018
Shandong University
2018
Shandong First Medical University
2018
The pregnane X receptor (PXR) mediates the resistance of sorafenib in hepatocellular carcinoma (HCC) by promoting clearance or elimination <italic>via</italic> drug resistance-related downstream genes PXR. Rhamnetin drepresses activation PXR miR-148a.
<h3>Objective</h3> Precise genetic analyses were conducted with ring finger protein 213 (<i>RNF213</i>) in relation to a particular clinical phenotype Chinese patients moyamoya disease (MMD) determine whether heterozygosity is responsible for the early-onset and severe form of this disease. <h3>Methods</h3> A case–control study <i>RNF213</i> p.R4810K involving 1,385 MMD 2,903 normal control participants was performed. Correlation between genotype or different features also statistically...
Abstract As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine efficacy immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts application in tumor In this study, we identified a subpopulation CD146 + TAMs that exerted antitumor activity both human samples animal models. expression was negatively controlled by STAT3 signaling. Reducing population promoted development facilitating...
Abstract Purpose The goal is to identify risk factors associated with receiving a blood transfusion during the perioperative period in patients who undergo total laparoscopic hysterectomy (TLH) using large-scale national database. Methods In this retrospective analysis, data from Nationwide Inpatient Sample (NIS) was utilized review medical records of all underwent TLH 2010 2019. researchers identified had received and compared those not. subsequent were examined: hospital characteristics...
Remodeling spacing factor 1 (RSF-1/HBXAP) has been linked to a variety of cancer types, however, its roles and the therapeutic potential are not clear in cervical cancer.
Abstract The PI3K/Akt pathway is overexpressed in nearly 50% of hepatocellular carcinomas and inhibits apoptosis by promoting the expression antiapoptotic genes. Serine protease inhibitors have been shown to induce hepatoma cells downregulating SPINK13 pathway. In this study, was expressed lentiviral vectors. Changes signaling adapter proteins, regulatory cell cycle biological behavior carcinoma were observed nude mouse xenograft models. underlying mechanism endogenous SPINK13-induced...
Background: Serine peptidase inhibitor, Kazal type 13 (SPINK13) (also known as hespinter) is a low-molecular-weight inhibitor of uPA that was discovered in 2006. It detected prokaryotic cells 2013 for the first time and preliminarily shown to inhibit hepG2 liver cancer growth vitro 2015. In this study, differentially transcribed genes MHCC97-H caused by SPINK13 treatment were studied transcriptomics molecular mechanism suppressing tumor proposed using bioinformatics. Methods: Preliminary...