A5100392852- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Anatomy and Medical Technology
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Lung Cancer Research Studies
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Antimicrobial Peptides and Activities
Lanzhou University
2022-2023
Xinjiang Academy of Agricultural and Reclamation Science
2023
Lanzhou University Second Hospital
2022-2023
Nanjing Chest Hospital
2023
Nanjing Medical University
2022-2023
Nanjing Brain Hospital
2023
Tianjin Medical University Cancer Institute and Hospital
2022
Sir Run Run Shaw Hospital
2021
Zhejiang University
2021
First Affiliated Hospital Zhejiang University
2021
Dysregulated expression of microRNAs is often found in gastric cancer, and it contributes to the pathogenesis cancer via regulation cell cycle, proliferation, apoptosis, migration, invasion.In this study, we aimed investigate role miR-367 invasion metastasis cancer.The correlation between level clinicopathologic features 37 patients with was analyzed by using real-time polymerase chain reaction (RT-PCR). In addition, investigated effect on migration lines HS746T SGC-7901 transwell...
Breast cancer is the most common malignancy in women which increases gradually all over world. LncRNA GACAT3 has been found to be increased gastric and associated with tumor malignancy. However, whether plays a role regulation of breast not known. In presen t study, we that expression was tissues cells compared adjacent normal cells. High correlated poor prognosis patients. cyclin D2 (CCND2) contained binding site miR-497. miR-497 decreased Low tissues, negatively GACAT3. Downregulation...
Colorectal cancer (CRC) is one of the most common leading causes cancer-related deaths in world. Recent studies showed that microRNAs (miRNAs) play important roles development diseases, such as CRC. However, role miR-873-5p CRC remains unclear. In this study, we found expression was down-regulated tissues and cell lines, down-regulation associated with poor survival patients MiR-873-5p could function a tumour suppressor It inhibit growth, proliferation, migration invasion cells; influence...
Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed cancers. Long non-coding RNAs (lncRNAs) can regulate gene expression and contribute to tumorigenesis through interactions with microRNAs (miRNAs). However, there are only few studies reporting the profiles lncRNAs, miRNAs, mRNAs in SCLC. Also, role differentially expressed relation competitive endogenous (ceRNA) network SCLC remain unclear.In present study, we first...
Objective: MicroRNAs (miRNAs) are highly involved in cancer development, including cervical (CC). In this study, we aimed to investigate the role and possible mechanism of a poorly studied miRNA, miR-1193, CC progression. Materials Methods: Expression miR-1193 was determined 60 pairs samples. The impacts on cell proliferation, invasion migration capacities were verified by CCK-8, transwell wound healing assays, respectively. Then, bioinformatics prediction, luciferase reporter assay, qRT-PCR...
Abstract The gasdermin E gene ( GSDME , also known as DFNA5 ) is mutated in familial aging-related hearing loss. Recent studies have revealed that the expression of suppressed many cancer types; however, little about function head and neck squamous cell carcinoma (HNSCC). Accordingly, aim present study was to evaluate explore its prognostic value HNSCC. We used a set bioinformatics tools, including Oncomine, TIMER, TISIDB, cBioPortal, GEPIA, analyze patients with HNSCC from public databases....
Abstract Background: Hepatocellular Carcinoma (HCC) is the second primary causes of cancer death globally, And sixth mostly common malignant liver tumor with poor clinical results. The long term survival HCC patients was effected and influenced by low rate early diagnosis high risk recurrence metastasis in post operative .Although had improved due to diagnosis, In Addition Increasing amount non-coding RNAs (lncRNAs) have been revealed be implicated carcinogenesis progression HCC. potential...
Objective To combine anatomage table technique of multi-touch virtual anatomy system (virtual autopsy table) with case-based teaching, and the evaluation was done in appendicectomy surgical experiment. Methods A total 72 subjects were selected from 2015 class 5+ 3 clinical students Fujian Medical University divided into two groups. The experimental group used cooperate multimedia CBL case teaching + AT method. control traditional groups effects evaluated objectively at end...
The interplay between chromatin remodeling factors and lncRNAs is crucial for the regulation of gene expression diseases including cancer, however, precise role in tumorigenesis still remains elusive. Here we demonstrated a SMARC6-interacting long non-coding RNA (LINC00559) NSCLC tumorigenicity. Gain- loss-of-function studies show that LINC00559 promotes cancer cell growth, colony formation cell-cycle progression vitro as well xenograft mice. Mechanistically, recruits SMARCA6 ZBTB18 to...
Abstract Background Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed cancers. Long non-coding RNAs (lncRNAs) can regulate gene expression and contribute to tumorigenesis through interactions with microRNAs (miRNAs). However, there are only few studies reporting the profiles lncRNAs, miRNAs, mRNAs in SCLC. Also, role differentially expressed relation competitive endogenous (ceRNA) network SCLC remain unclear. Results In...