A5063231916- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Heat shock proteins research
- Ferroptosis and cancer prognosis
- Genetic and rare skin diseases.
- RNA Research and Splicing
- Cutaneous lymphoproliferative disorders research
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Cancer, Hypoxia, and Metabolism
- Cancer and Skin Lesions
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- Digestive system and related health
- Hydrogen Storage and Materials
- Dermatological and Skeletal Disorders
- Autophagy in Disease and Therapy
- Ammonia Synthesis and Nitrogen Reduction
- Immune Cell Function and Interaction
- Diverse Musicological Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Hunan Normal University
2018-2024
Max-Planck-Institut für Nachhaltige Materialien
2023-2024
Mayo Clinic in Arizona
2024
Peking Union Medical College Hospital
2023
Central South University
2011-2023
Chinese Academy of Medical Sciences Dermatology Hospital
2010-2023
Second Xiangya Hospital of Central South University
2017-2023
Weatherford College
2022
Hubei Urban Construction Vocational and Technological College
2020-2021
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that cytosolic lncRNA P53RRA is downregulated cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH Cfp1 silenced or increased expression, respectively. bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 871 RRM interaction domain G3BP1...
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which DNA methylation modifier, interacted with WDR76 to inhibit by activating lipid metabolism-associated genes, including GLUT1, and related genes SCD1 FADS2, turn, involved Warburg effect.WDR76 targeted these expression dependent manner LSH chromatin...
Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global biochemical profile and provide a novel metabolism-related target improve therapeutic regimen of nasopharyngeal carcinoma (NPC). We used metabolomics approach investigate EBV-modulated metabolic changes, found that exogenous overexpression EBV-encoded latent membrane protein 1 (LMP1) significantly increased glycolysis. The deregulation several glycolytic genes, including hexokinase 2 (HK2), determined be...
The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and conformational maturation of various oncogenic proteins in cancer. loading kinases to Hsp90 actively mediated by cochaperone Cdc37. crucial role Hsp90-Cdc37 complex has made it an exciting target cancer treatment. In this study, we characterize Cdc37 interaction drug disruption using a reconstituted system. GST pull-down assay ELISA show that binds ADP-bound/nucleotide-free but not ATP-bound Hsp90....
Abstract Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential cancer cells. Here, we report a role for chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), prevalent China. LSH expression was increased NPC, where it controlled by Epstein–Barr virus-encoded protein LMP1. In NPC cells vitro and vivo, promoted progression part regulating of fumarate hydratase (FH), core component...
(-)-Epigallocatechin-3-gallate [(-)-EGCG], the most abundant polyphenolic catechin in green tea, showed chemoprevention and anticancer activities. (-)-EGCG was reported to bind C-terminal domain of heat shock protein 90 (Hsp90). The purpose this study is investigate as a novel Hsp90 inhibitor impair superchaperone complex for simultaneous downregulation oncogenic proteins pancreatic cancer cells. MTS assay that exhibited antiproliferative activity against cell line Mia Paca-2 vitro with IC50...
The signaling pathway-based stratification in chromatin modification could predict clinical outcome more reliably than morphology-alone-based classification schemes gliomas. Here we reported a role of the chromatin-remodeling factor lymphoid-specific helicase (LSH) Among astrocytomas grade I to III and glioblastoma IV, LSH were almost completely expressed all cases, strongly correlated with progression poor prognosis patients glioblastoma. Ectopic expression promoted tumor formation....
DNA methylation is an important epigenetic modification as a hallmark in cancer. Conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) by ten-eleven translocation (TET) family enzymes plays biological role embryonic stem cells, development, aging and disease. Lymphoid specific helicase (LSH), chromatin remodeling factor, regarded reader 5-hmC. Recent reports show that the level 5-hmC altered various types cancers. However, change levels cancer associated metastasis not...
Abstract The lncRNA HOTAIR is a critical regulator of cancer progression. Chromatin remodeling factor LSH for normal development plants and mammals. However, the underlying mechanisms causing this in are not entirely clear. functional diversification FOXA1 FOXA2 contributes to target genes during evolution carcinogenesis. Little known about ratio cancer. We here found that both overexpression was significantly correlated with poor survival patients lung adenocarcinoma (ADC). Also, linked...
Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology treatment of cancer, regulation oncogene by chromatin at post-transcriptional level is critical remains unclear. We have investigated role GINS4 NSCLC.The expression modifier lymphoid-specific helicase (LSH) was assessed tumor normal tissue from 79 patients with NSCLC clinical characteristics. HBE, A549, H358, H522, PC9, 95C 95D were cultured after overexpression or silencing GIAT4RA....
Abstract While considerable efforts have been devoted to developing functionalized covalent organic frameworks (COFs) as oxygen evolution electrocatalysts in recent years, studies related the investigation of true catalytically active species for reaction (OER) remain lacking field. In this work, a cobalt‐functionalized COF (TpBpy‐Co) is studied electrochemical OER catalyst through series measurements and post‐electrolysis characterizations. These results suggest that cobalt oxide‐based...
The epidermal growth factor receptor (EGFR), a ubiquitously expressed tyrosine kinase, is an important in carcinogenesis. Transcriptional intermediary 2 (TIF2), member of the p160 nuclear co-activator gene family, linked to proliferation cancer cells. However, direct interplay between EGFR and receptors remains unclear. Our previous study demonstrated that could directly bind cyclin D1 promoter under regulation oncoprotein latent membrane protein 1 (LMP1), but it also indicated other factors...
Abstract Most cancer patients receive radiotherapy in the course of their disease and occurrence radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during development are poorly understood. Here, we demonstrate aryl hydrocarbon receptor (AhR) plays a vital role maintenance stem-like properties. AhR promotes phenotype drives metastasis by directly targeting promoters ‘stemness’ genes, such as ATP-binding cassette sub-family G...