A5100348671- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- RNA regulation and disease
- Cancer-related gene regulation
- Atherosclerosis and Cardiovascular Diseases
- Cancer Mechanisms and Therapy
- GDF15 and Related Biomarkers
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Mathematical Biology Tumor Growth
- Viral-associated cancers and disorders
Panyu Hospital of Chinese Medicine
2024-2025
Zigong First People's Hospital
2025
Zhujiang Hospital
2025
Southern Medical University
2025
Qilu Hospital of Shandong University
2025
China Medical University
2017-2024
Shantou University
2024
First Hospital of China Medical University
2018-2024
Henan University
2022-2024
Huazhong University of Science and Technology
2021-2024
MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 pathogenesis lung cancer. The downregulation cancer cells could be rescued following inhibition DNA methylation. Ectopic expression significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease growth vivo vitro. Further, both Cdc42 were confirmed targets miR-137.
Rationale: Angiogenesis is a crucial step towards tissue repair and regeneration after ischemia.The role of circulating exosomes in angiogenic signal transduction has not been well elucidated.Thus, this study aims to investigate the effects coronary serum from patients with myocardial ischemia on angiogenesis elucidate underlying mechanisms.Methods Results: The were enrolled according inclusion exclusion criteria.Coronary blood was obtained angiography catheter.Serum purified characterized...
Abstract Background Glioma is the most common and lethal primary brain tumor in adults, angiogenesis one of key factors contributing to its proliferation, aggressiveness, malignant transformation. However, discovery novel oncogenes study molecular regulating mechanism based on circular RNAs (circRNAs) may provide a promising treatment target glioma. Methods Bioinformatics analysis, qPCR, western blotting, immunohistochemistry were used detect expression levels ISL2 , miR-342–3p, circRNA ARF1...
Abstract Glioma is the most aggressive and common malignant neoplasms in human brain tumors. Numerous studies have showed that glioma stem cells (GSCs)drive progression of gliomas. Recent revealed circRNAs can maintain stemness promote cells. We used bioinformatics analysis to identify potential RNA-binding proteins (RBPs) glioma. qRT-PCR, western blotting, RNA FISH, pull-down, immunoprecipitation assay, ChIP, immunohistochemistry, immunofluorescence methods were quantified expression...
Neuronal apoptosis and inflammation are two critical factors that impede functional recovery post spinal cord injury (SCI). Previous studies have demonstrated the inhibitory effects of integrated stress response inhibitor (ISRIB) on neuroinflammation in brain injury. However, whether ISRIB can regulate neuron death context SCI remains elusive. We employed an oxygen-glucose deprivation/reperfusion (OGD/R) model to simulate ischemia-reperfusion utilized lipopolysaccharide (LPS) activate...
Methylation plays an important role in the etiology and pathogenesis of colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) pathways CRC by comprehensive bioinformatics analysis.Data gene expression microarrays (GSE68468, GSE44076) methylation (GSE29490, GSE17648) were downloaded from GEO database. Aberrantly methylated-DEGs obtained GEO2R. Functional enrichment analyses selected performed using DAVID Protein-protein interaction...
Rationale: Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration. However, the molecular mechanisms underlying MSCs activation remain largely unknown, thus hindering their clinical translation. Exosomes are small vesicles that act as intercellular messengers, potential for cell pathological conditions has not been fully characterized yet. Here, we aim to investigate whether serum exosomes involved remote of after myocardial infarction (MI). Methods: We...
Abstract Background Glioma is the most common and malignant tumor of central nervous system. The initiation, self-renewal, multi-lineage differentiation abilities glioma stem cells (GSCs) are responsible for proliferation recurrence. Although circular RNAs (circRNAs) play vital roles in progression glioma, detailed mechanisms remain unknown. Methods qRT-PCR, western blotting, immunohistochemistry, bioinformatic analysis were performed to detect expression circATP5B, miR-185-5p, HOXB5, SRSF1....
The signaling pathway-based stratification in chromatin modification could predict clinical outcome more reliably than morphology-alone-based classification schemes gliomas. Here we reported a role of the chromatin-remodeling factor lymphoid-specific helicase (LSH) Among astrocytomas grade I to III and glioblastoma IV, LSH were almost completely expressed all cases, strongly correlated with progression poor prognosis patients glioblastoma. Ectopic expression promoted tumor formation....
As the most critical alternative splicing regulator, heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be implicated in various aspects of cancer. However, comprehensive understanding hnRNPs cancer is still lacking. The molecular alterations and clinical relevance hnRNP genes were systematically analysed 33 types based on next-generation sequence data. expression, mutation, copy number variation, functional pathways, immune cell correlations prognostic value...
Abstract Exosomes are an important carrier for cell communication. miRNAs in exosomes potential biomarkers and therapeutic targets different types of cancer. However, the role exosomal medulloblastoma (MB) patients is largely unknown. In this study, we reported that there was a higher level miR-130b-3p derived from MB patient plasma compared with healthy control plasma. could transfer to line played suppressor roles proliferation. suppressed tumorigenesis by targeting previously unknown...
Rationale: Glioma is the most common primary malignant tumor of human central nervous system, and its rich vascular characteristics make anti-angiogenic therapy become a therapeutic hotspot.However, existence glioma VM makes ineffective.SUMOylation post-translational modification that affects cell tumorigenicity by regulating expression activity substrate proteins.Methods: The binding IGF2BP2 SUMO1 were identified using Ni 2+ -NTA agarose bead pull-down assays, CO-IP western blot; in vitro...
Abstract Long noncoding RNAs (lncRNAs) contribute to esophageal squamous cell carcinoma (ESCC) progression, but the underlying mechanisms remain elusive. In this study, we verified a hitherto uncharacterized hypoxia-responsive lncRNA, G077640, which is upregulated in human ESCC cells and tissues, supporting proliferation migration of cells. Mechanistically, G077640 prevented hypoxia-inducible factor-1α (HIF1α) from being degraded by directly interacting with histone H2AX further modulated...
Sorafenib is the first‑line treatment for advanced hepatocellular carcinoma (HCC). Since many HCC patients experience drug resistance, there an urgent need to discover more effective therapeutic strategies overcome resistance. Long non‑coding RNAs (lncRNAs) play important role in tumor However, research on of lncRNA H19 sorafenib resistance quite limited. In present study, CCK‑8 assay, RT‑qPCR, EdU staining, immunofluorescence and western blot analysis were used detect effect cells....
Abstract Glioblastoma multiforme (GBM) is the most lethal type of craniocerebral gliomas. Glioma stem cells (GSCs) are fundamental reasons for malignancy and recurrence GBM. Revealing critical mechanism within GSCs’ self-renewal ability essential. Our study found a novel circular RNA (circRPPH1) that was up-regulated in GSCs correlated with poor survival. The effect circRPPH1 on malignant phenotype detected vitro vivo. Mechanistically, UPF1 can bind to maintain its stability. Therefore, more...
Granulosa cell proliferation and survival are essential for normal ovarian function follicular development. Long non-coding RNAs (lncRNAs) have emerged as important regulators of differentiation. Nuclear paraspeckle assembly transcript 1 (NEAT1) has been implicated in various cellular processes, but its role granulosa remains unclear. We investigated the lncRNA NEAT1 human granulosa-like tumor cells (KGN). The effects overexpression or silencing on cycle were evaluated using CCK-8 assays...
Intervertebral disc degeneration (IVDD) is a core factor in spinal degeneration. To date, there no effective treatment for IVDD. It urgent to identify the pathogenesis of IVDD develop strategies treatment. Alleviating endplate chondrocyte promising strategy treatment, while mitophagy prevents chondrocytes. Stigmasterol (STM) protects neurons from injuries by triggering mitophagy, yet effect STM on chondrocytes has not been reported. In this study, was induced interleukin-1β, and ribonucleic...
The molecular mechanism of Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) remains elusive. A collection regulators including transcription factor and noncoding RNA (ncRNAs) may affect the carcinogenesis EBVaGC by regulating expression function key genes. In this study, integration multi-level data bioinformatics approach was used to identify elements their interactions involved in network regulation.Data gene profiling sets (GSE51575) downloaded from GEO database. Differentially...