A5072136462- Spinal Cord Injury Research
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Musculoskeletal pain and rehabilitation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Circular RNAs in diseases
- Medical Imaging and Analysis
- Bone Tissue Engineering Materials
- Trauma and Emergency Care Studies
- Graphene and Nanomaterials Applications
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- RNA Research and Splicing
- Bone health and osteoporosis research
- Pelvic and Acetabular Injuries
- Extracellular vesicles in disease
- Bone Metabolism and Diseases
- Clinical practice guidelines implementation
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
Tianjin Medical University General Hospital
2016-2025
Shandong University
2021-2025
Qilu Hospital of Shandong University
2021-2025
Second Hospital of Shandong University
2023-2024
Advanced Medical Research Institute
2022-2023
Shanghai Ninth People's Hospital
2023
China International Science and Technology Cooperation
2020
Tianjin Medical University
2013-2017
Foundation for Physical Medicine and Rehabilitation
2017
Objectives To evaluate the most up-to-date burden of traumatic brain injury (TBI) and spinal cord (SCI) analyse their leading causes in different countries/territories. Design An analysis Global Burden Disease (GBD) data. Setting The epidemiological data were gathered from GBD Results Tool (1 January, 1990─31 December 2019) covering 21 regions 204 countries/ territories. Participants Patients with TBI/SCI. Main outcomes measures Absolute numbers age-standardised rates/estimates incidence,...
Spinal cord injury (SCI) causes motor, sensory and automatic impairment due to rarely axon regeneration. Developing effective treatment for SCI in the clinic is extremely challenging because of restrictive axonal regenerative ability disconnection neural elements after injury, as well limited systemic drug delivery efficiency caused by blood spinal barrier. To develop an non-invasive strategy clinic, we generated autologous plasma exosome (AP-EXO) based biological scaffold where AP-EXO was...
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal barrier (BSCB). To address these challenges, new nano complex that achieves targeted damaged spinal is proposed, which contains mesoporous silica nanoparticle core loaded with microRNA cloaking layer human umbilical mesenchymal stem...
Abstract Neural stem cells (NSCs) therapy is promising for treating neurodegenerative disorders and neural injuries. However, the limited in vitro expansion, spontaneous differentiation, decrease stemness obstruct acquisition of high quantities NSCs, restricting clinical application cell‐based therapies tissue engineering. This article reports a facile method promoting NSCs expansion maintaining using wireless electrical stimulation triggered by piezoelectric nanomaterials. A nanofibrous...
Background Aging is an influential risk factor for progression of both degenerative and oncological diseases the bone. Osteosarcoma, considered most common primary mesenchymal tumor bone, a worldwide disease with poor 5-year survival. This study investigated role aging-/senescence-induced genes (ASIGs) in contributing to osteosarcoma diagnosis, prognosis, therapeutic agent prediction. Methods Therapeutically Applicable Research Generate Effective Treatments (TARGET), Gene Expression Omnibus...
Tissue engineering is emerging as a promising approach for cartilage regeneration and repair. Endowing scaffolds with cartilaginous bioactivity to obtain bionic microenvironment regulating the matching of scaffold degradation play crucial role in regeneration. Poly(glycerol sebacate) (PGS) representative thermosetting bioelastomer known its elasticity, biodegradability, biocompatibility widely used tissue engineering. However, modification drug loading PGS still key challenge due high...
N1-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, dynamically regulated under stress. However, the characteristics functions m1A primary neurons oxygen glucose deprivation/reoxygenation (OGD/R) induced remain unclear. We first constructed a mouse cortical neuron OGD/R model then used methylated RNA immunoprecipitation (MeRIP) sequencing technology to demonstrate that mRNAs during induction. Our...
Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death. China has the largest population of patients with traumatic injury. Previous studies in have mostly been regional scope; national-level rare. To best our knowledge, no study treatment status economic burden performed. This retrospective aimed examine epidemiological clinical features, status, at national level. We included 13,465 who were injured between January 2013 December 2018...
Study designHospital-based retrospective review.ObjectiveTo describe the epidemiological characteristics and trends of traumatic spinal cord injury in Tianjin, China.SettingTianjin Medical University General Hospital.MethodsMedical records 239 patients with admitted to a general hospital from 1998 2009 were reviewed. Variables included gender, age, marital status, occupation, etiology, time injury, level, severity injury. Epidemiological different countries compared.ResultsOver this period,...
The prevalence of depression among people with chronic pain remains unclear due to the heterogeneity study samples and definitions depression. We aimed identify sources variation in generate clinical prediction models estimate probability individuals pain.
Rationale: The inflammatory microenvironment and resulting neuronal loss following spinal cord injury (SCI) impede the repair process. Endogenous neural stem cells (NSCs), which are constrained by neuroinflammation slow differentiation rates, unable to effectively facilitate recovery. Method: In this study, coaxial electrospinning technology was employed fabricate a nano-fiber/net artificial bionic dura mater (NABDM). This structure featured core-shell structure, with nafamostat mesylate...
Neuronal apoptosis and inflammation are two critical factors that impede functional recovery post spinal cord injury (SCI). Previous studies have demonstrated the inhibitory effects of integrated stress response inhibitor (ISRIB) on neuroinflammation in brain injury. However, whether ISRIB can regulate neuron death context SCI remains elusive. We employed an oxygen-glucose deprivation/reperfusion (OGD/R) model to simulate ischemia-reperfusion utilized lipopolysaccharide (LPS) activate...
Osteoprotegerin (OPG) is implicated in the pathogenesis of postmenopausal osteoporosis, and other metabolic bone diseases caused by estrogen deficiency. Previous studies have demonstrated that may stimulate OPG expression osteoblast cells at transcriptional level; however, whether can regulate a post-transcriptional level remains elusive. The present study aimed to investigate role microRNA (miRNA) estrogen‑mediated production human osteoblast‑like MG‑63 cells. results from ELISA, western...
Spinal cord injury (SCI) severely and irreversibly damages the central nervous system. Neurotropin (NTP), a nonprotein extract obtained from inflamed rabbit skin inoculated with vaccinia virus, is drug that has been used for more than sixty years to alleviate neuropathic pain. It also reportedly exerts neuroprotective role in peripheral nerves response various system diseases, such as brain Alzheimer disease. However, whether NTP promotes SCI recovery remains unknown. This study evaluated...