A5100398710- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Calcium Carbonate Crystallization and Inhibition
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Supercapacitor Materials and Fabrication
- Antimicrobial Peptides and Activities
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- Photodynamic Therapy Research Studies
- Bone and Dental Protein Studies
- Analytical Chemistry and Sensors
- Orthopaedic implants and arthroplasty
- Advancements in Battery Materials
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Sulfur Compounds in Biology
- Sparse and Compressive Sensing Techniques
- Graphene and Nanomaterials Applications
- Nonlinear Optical Materials Studies
- Microwave Engineering and Waveguides
- Laser Material Processing Techniques
Sichuan University
2010-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
University of Macau
2024
South China University of Technology
2024
Nankai University
2020-2023
Huazhong University of Science and Technology
2021-2023
Tongji Hospital
2021-2023
University of Chinese Academy of Sciences
2022
Chengdu University of Information Technology
2022
Polylactic acid/Hydroxyapatite (PLA/HA) composite was widely studied and applied in the field of biomaterials for its good processability, bioactivity, mechanical properties. In addition to traditional preparation methods, additive manufacturing has also been adopted prepare PLA/HA composites with customized geometries. This work combined comprehensive optimized PLLA (L-polylactic acid)/nano-HA (nHA) low-cost stable Fused deposition modeling (FDM) technology successfully PLLA/nHA porous bone...
Abstract Immunogenic cell death (ICD) approaches by encumbering mitochondrial functions provide great promise for the treatment of malignant tumors, but these kinds ICD strategies are still in their infancy. Here, one multifunctional drug‐loaded, cascade‐targeted, and enzyme‐instructed self‐assembling peptide nanomedicine ( Comp. 4 ) ICD‐based cancer therapy is constructed. consists 1) lonidamine (LND) that specifically interferes with functions; 2) a programmed ligand 1 (PD‐L1) binding...
Immunogenic cell death (ICD) plays a major role in cancer immunotherapy by stimulating specific T responses and restoring the antitumor immune system. However, effective type II ICD inducers without biotoxicity are still very limited. Herein, tentative drug- or photosensitizer-free strategy was developed employing enzymatic self-assembly of peptide F-pY-T to induce mitochondrial oxidative stress cells. Upon dephosphorylation catalyzed alkaline phosphatase overexpressed on cells,...
TMVP1 is a novel tumor targeting polypeptide screened by our laboratory with core sequence of five amino acids LARGR. It specially binds to vascular endothelial growth factor receptor-3 (VEGFR-3), which mainly expressed on neo-lymphatic vessels in sentinel lymph node (SLN) metastasis adults. Here, we prepared targeted nanoprobe using TMVP1-modified nanomaterials for SLN imaging.In this study, polymer were loaded the near-infrared (NIR) fluorescent dye, indocyanine green (ICG), prepare...
Abstract In situ mineralization is a promising strategy to mimic the physicochemical properties of biominerals and widely applied in field bone repair. Given high requirement for substance exchange cranial regeneration, mineralized organic–inorganic hybrid materials exhibit advantages. However, integration remarkable mineral content, mechanical properties, osteogenic also remains major challenge. Herein, enhanced through combining enzymatic anion‐boosted promote efficiency, properties. Based...
Precise manipulation of cancer cell death by harnessing reactive oxygen species (ROS) is a promising strategy to defeat malignant tumors. However, it quite difficult produce active ROS with spatial precision and regulate their biological outcomes. We succeed here in selectively generating short-lived lipid-reactive hydroxyl radicals (•OH) adjacent membranes, successively eliciting lipid peroxidation ferroptosis. DiFc-K-pY, phosphorylated self-assembling precursor that consists two branched...
TMTP1 is a polypeptide independently screened in our laboratory, which can target tumors situ and metastases. In previous work, we have successfully developed near-infrared (NIR) probe TMTP1-PEG4-ICG for tumor imaging. However, the limited ability to micrometastases hinders its further clinical application. Multimerization of peptides has been extensively demonstrated as an effective strategy increase receptor binding affinity due "multivalent effect" or "apparent cooperative affinity". this...
Cisplatin-paclitaxel (TP) combination chemotherapy as the first-line therapy for numerous cancers is hindered by its inadequate accumulation in tumors and severe side effects resulting from non-specific distribution. The aim of this study to explore whether TMTP1-modified, cisplatin paclitaxel prodrugs co-loaded nanodrug could improve cervical cancer relieve through active passive tumor targeting controlled drug release.TDNP, with capacities release, was prepared co-deliver prodrugs....
Biomineralization is an important process of bone tissue generation. Calcium (Ca) and phosphate (P) ions aggregate nucleate under the regulation biomolecules at initial mineralization stage. Due to complexity physiological environment, movement behavior mechanism calcium ions, as well effect on them, are not clear. In this study, computer simulations experimental verification were applied investigate characteristics biomineralization from view ion aggregation nucleation. The results prove...
The mortality of ovarian cancer (OC) has long been the highest among gynecological malignancies. Although OC is considered to be an immunogenic tumor, effect immunotherapy not satisfactory. immunosuppressive microenvironment one reason for this, and absence recognized effective antigens vaccines another. Chemotherapy, as most commonly used treatment OC, can produce chemotherapy-associated (CAAs) during show in situ vaccine. Herein, we designed antigen capture nano-vaccine NP-TP1@M-M with...
A drug delivery platform for enhancing lung cancer treatment with controlled release, magnetic targeting and specific cells targeting.
Femtosecond laser optimization of PEEK: efficient bioactivity achieved by synergistic surface chemistry and structures.
The surface activation of titanium plays a key role in the biological properties implants as bone repair materials. Improving ability to induce apatite precipitation on was well-accepted bioactivation route. In this study, advanced femtosecond laser microfabrication applied modify surfaces, and effect etching investigated compared with popular modification methods. Meanwhile, mechanism formation after interpreted from point materials science. physical-chemical characterization results showed...
Due to the body's systemic distribution of photothermal agents (PTAs), and imprecise exposure lasers, therapy (PTT) is challenging use in treating tumor sites selectively. Striving for PTT with high selectivity precise treatment nevertheless important, order raise survival rate cancer patients lower likelihood adverse effects on other body sections. Here, we studied cold atmospheric plasma (CAP) as a supplementary procedure enhance cancer, using classical photothermic agent's gold nanostars...
Poly(etheretherketone) (PEEK) is regarded as an attractive orthopedic material because of its good biocompatibility and mechanical properties similar to natural bone. The efficient activation methods for the surfaces PEEK matrix materials have become a hot research topic. In this study, method using femtosecond laser (FSL) followed by hydroxylation was developed achieve bioactivity. It produces microstructures, amorphous carbon, grafted -OH groups on surface enhance hydrophilicity energy....
The osteogenic and angiogenic characteristics are crucial for the selection of bone substitute materials structural design. This study proposed a porous PLGA/n-HA/MgP composited scaffold by printing poly (lactide-coglycolide) (PLGA), nano-hydroxyapatite (n-HA), magnesium phosphate (MgP). physicochemical properties, activities, pro-angiogenic impacts 3D printed PLGA/n-HA scaffolds with variable MgP concentration were investigated. results indicated that presence in composite promoted...