A5100318596- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Plasmonic and Surface Plasmon Research
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Photodynamic Therapy Research Studies
- Bacteriophages and microbial interactions
- DNA and Nucleic Acid Chemistry
- Advanced Biosensing Techniques and Applications
- Advanced Chemical Sensor Technologies
- Quantum Dots Synthesis And Properties
- Natural product bioactivities and synthesis
- Biosensors and Analytical Detection
- Extracellular vesicles in disease
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Electrochemical Analysis and Applications
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Transition Metal Oxide Nanomaterials
- Carbon and Quantum Dots Applications
Tianjin Medical University
2017-2024
Chongqing Medical University
2014-2024
Xinqiao Hospital
2017-2024
Tianjin First Center Hospital
2017-2024
Army Medical University
2014-2024
Beijing Academy of Artificial Intelligence
2024
State Key Laboratory of Surface Physics
2024
Nanjing University of Aeronautics and Astronautics
2024
Yanshan University
2024
State Key Laboratory of Metastable Materials Science and Technology
2024
Nucleocytoplasmic coupling is mediated by outer nuclear membrane (ONM) nesprin proteins and inner Sun proteins. Interactions spanning the perinuclear space create nesprin–Sun complexes connecting cytoskeleton to components. A search for displaying a conserved C-terminal sequence present in nesprins 1–3 identified 4 (Nesp4), new member of this family. Nesp4 kinesin-1-binding protein that displays Sun-dependent localization ONM. Expression associated with dramatic changes cellular organization...
Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially...
Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided resection.
Abstract Immunotherapy has received widespread attention for its effective and long‐term tumor‐eliminating ability. However, immunogenic “cold” tumors, such as prostate cancer (PCa), the low immunogenicity of tumor itself is a serious obstacle to efficacy. Here, this work reports strategy enhance PCa by triggering cascade self‐enhanced ferroptosis in cells, turning from “hot”. This develops transformable self‐assembled peptide TEP‐FFG‐CRApY with alkaline phosphatase (ALP) responsiveness...
Microvascular barrier dysfunction is the central pathophysiological feature of acute lung injury (ALI). RAB26 a newly identified small GTPase involved in regulation endothelial cell (EC) permeability. However, mechanism behind this protection has not been clearly elucidated. Here we found that promoted integrity adherens junctions (AJs) macroautophagy/autophagy-dependent manner ALI. frequently downregulated mouse lungs after LPS treatment. Mice lacking Rab26 exhibited phosphorylated SRC...
Photodynamic therapy (PDT) has been widely applied in the clinic for treatment of various types cancer due to its precise controllability, minimally invasive approach and high spatiotemporal accuracy as compared with conventional chemotherapy. However, porphyrin-based photosensitizers (PSs) used clinics generally suffer from aggregation-caused reductions generation reactive oxygen species (ROS) limited tissue penetration because visible light activation, which greatly hampers their...
Triple-negative breast cancer (TNBC) does not respond to many targeted drugs due the lack of three receptors (i.e., estrogen receptor, progesterone and human epidermal growth factor receptor-2), which makes it difficult for TNBC detection treatment. As compared traditional treatments such as surgery chemotherapy, photodynamic therapy (PDT) has emerged a promising approach treating its precise controllability, high spatiotemporal accuracy, minimal invasive nature. However, photosensitizers...
Transition-metal-catalyzed difunctionalization of olefins constitutes a fertile synthetic platform for rapid access to complex molecules from bulk chemicals. However, substrates featuring fluoroalkyl substituents are rarely employed because facile β-fluoride elimination pathways. Herein, we report hydroalkylation trifluoromethylalkenes with alkyl halides under nickel catalysis that enables the construction 1,1,1-trifluoropropane derivatives. The common pathway is suppressed by identifying...
FeNi 3 alloy is adopted for catalyzing nitrate and carbon dioxide reduction to produce urea at ambient conditions. The catalyst delivers a larger yield rate faradaic efficiency in comparison with the counterparts.
γ-Glutamyltransferase (GGT) has been recognized as an important clinical biomarker that is closely related to many diseases. Visualizing the GGT fluctuation facilitates early disease-related diagnosis and therapy. Herein, activated probe (NIR-GGT) for imaging of activity was prepared. The consists a stable NIR fluorophore with tunable amino group decorated γ-glutamate GGT-sensing unit linked by self-elimination group. NIR-GGT can sensitively recognize cause strong turn-on fluorescent...
Abstract The second near‐infrared (NIR‐II) theranostics offer new opportunities for precise disease phototheranostic due to the enhanced tissue penetration and higher maximum permissible exposure of NIR‐II light. However, traditional regimens lacking effective absorption uncontrollable excited‐state energy decay pathways often result in insufficient theranostic outcomes. Herein a nano‐agent (PS‐1 NPs) based on azulenyl squaraine derivatives with strong band centered at 1092 nm is reported,...
DNA nanostructures as scaffolds for drug delivery, biosensing, and bioimaging are hindered by its vulnerability in physiological settings, less favorable of incorporating arbitrary guest molecules other desirable functionalities. Noncanonical self-assembly with small an alternative system is attractive strategy to expand their applications multidisciplinary fields rarely explored. This work reports a nitrogen-enriched carbon dots (NCDs)-mediated nanostructure strategy. Given the excellent...
Immune cells are pivotal in cancer immunotherapy, yet their therapeutic effectiveness is often hampered by limited tumor infiltration and inhibitory microenvironments. An alkaline phosphatase (ALP)-responsive transformable supramolecular bis-specific cell engager (Supra-BiCE) to harness natural killer (NK)/T for effective immunotherapy introduced here. The Supra-BiCE, consisting of both SA-P (a phosphorylated peptide targeting blocking programmed death ligand 1 (PD-L1)) SA-T T immunoglobulin...
Abstract Immunogenic cell death (ICD) approaches by encumbering mitochondrial functions provide great promise for the treatment of malignant tumors, but these kinds ICD strategies are still in their infancy. Here, one multifunctional drug‐loaded, cascade‐targeted, and enzyme‐instructed self‐assembling peptide nanomedicine ( Comp. 4 ) ICD‐based cancer therapy is constructed. consists 1) lonidamine (LND) that specifically interferes with functions; 2) a programmed ligand 1 (PD‐L1) binding...
Abstract Acute lung injury (ALI) poses a significant and escalating medical challenge, where precise diagnosis timely intervention hold utmost importance in halting its deterioration. Nevertheless, persistent obstacles arise from the lack of agents proficient both real‐time efficient mitigation ALI. Here, biocatalytic second near‐infrared (NIR‐II) fluorescence‐illuminating nanoplatform is designed to simultaneously facilitate monitoring robust inflammation alleviation The study first...
We have demonstrated the proof-of-concept of a label-free biosensor based on emission induced by an extreme hot-spot plasmonic assembly. In this work, ultrathin linking layer composed cationic polymers and aptamers was fabricated to mediate assembly silver nanoparticles (AgNPs)-dyes-gold film with strongly coupled architecture through sensing target protein. Generation directional surface plasmon (SPCE) thus stimulated as means reporting biorecognition. Both biomolecules were totally free...