A5039579687- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- Photoacoustic and Ultrasonic Imaging
- Transition Metal Oxide Nanomaterials
- Perovskite Materials and Applications
- Gas Sensing Nanomaterials and Sensors
- Organic Light-Emitting Diodes Research
- Genomics and Phylogenetic Studies
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Catalysis and Oxidation Reactions
- Extracellular vesicles in disease
- X-ray Diffraction in Crystallography
- Magnetic and transport properties of perovskites and related materials
- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- Advanced Photocatalysis Techniques
- Quantum Dots Synthesis And Properties
- Molecular Sensors and Ion Detection
- Advanced Battery Materials and Technologies
- Sulfur Compounds in Biology
- Photochromic and Fluorescence Chemistry
- Solar-Powered Water Purification Methods
State Key Laboratory of Medicinal Chemical Biology
2021-2025
Nankai University
2003-2025
Dalian Maritime University
2024-2025
Advanced Research Institute
2025
China University of Mining and Technology
2015-2025
North China University of Water Resources and Electric Power
2025
Sun Yat-sen University
2025
Nanjing University of Posts and Telecommunications
2025
Tianjin University
2022-2024
Jilin Agricultural University
2024
Metagenomics is the study of genomic content a sample organisms obtained from common habitat using targeted or random sequencing. Goals include understanding extent and role microbial diversity. The taxonomical such usually estimated by comparison against sequence databases known sequences. Most published studies use analysis paired-end reads, complete sequences environmental fosmid BAC clones, assemblies. Emerging sequencing-by-synthesis technologies with very high throughput are paving way...
We sequenced 28 million base pairs of DNA in a metagenomics approach, using woolly mammoth (Mammuthus primigenius) sample from Siberia. As result exceptional preservation and the use recently developed emulsion polymerase chain reaction pyrosequencing technique, 13 (45.4%) sequencing reads were identified as DNA. Sequence identity between our data African elephant (Loxodonta africana) was 98.55%, consistent with paleontologically based divergence date 5 to 6 years. The includes surprisingly...
Fluorescence imaging in the spectral region beyond conventional near-infrared biological window (700-900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short-wave infrared (SWIR; 900-1700 modality past decade, long-wavelength biomedical is still suboptimal owing unsatisfactory materials properties of SWIR fluorophores. Taking advantage organic dots based on an aggregation-induced emission luminogen (AIEgen),...
Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially...
Near-infrared (NIR)-absorbing organic small molecules hold great promise as the phototheranostic agents for clinical translation by virtue of their intrinsic advantages such well-defined chemical structure, high purity, and good reproducibility. However, most currently available ones face challenges in varying degrees terms photothermal instability, photobleaching/reactive oxygen nitrogen species (RONS) inresistance, which indeed impair practical applications precise diagnosis treatment...
A family of donor–acceptor–donor (D–A–D) type near-infrared (NIR) fluorophores containing rigid nonplanar conjugated tetraphenylethene (TPE) moieties was designed and synthesized through Stille coupling reactions with electron-deficient [1,2,5]thiadiazolo[3,4-g]quinoxaline (QTD) or benzo[1,2-c;4,5-c′]bis[1,2,5]thiadiazole (BBTD) as acceptors. The absorption, fluorescence, electrochemical properties were studied. These compounds exhibited good aggregation-induced emission enhancement (AIEE)...
Second near-infrared (NIR-II, 1000-1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for vivo photoinduced imaging simultaneous therapy, as well the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular NIR-II-emissive theranostic system by encapsulating kind aggregation-induced emission luminogen (AIEgen,...
Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is shallow penetration depth. Two-photon microscopic imaging with excitation in longer-wavelength near-infrared (NIR) region (>1100 nm) and emission NIR-I (650–950 good choice to realize deep-tissue high-resolution imaging. Here, we report ultradeep two-photon bioimaging 1300 nm NIR-II (peak ∼810 based on NIR aggregation-induced luminogen (AIEgen). The crab-shaped AIEgen possesses planar...
Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) hypoxia-responsive prodrug multifunctional combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence photoacoustic (PA) brightness the strong light absorption ability, as well amplified type I II photodynamic therapy (PDT)...
Immunotherapy has received tremendous attention for tumor treatment, but the efficacy is greatly hindered by insufficient tumor-infiltration of immune cells and immunosuppressive microenvironment. The strategy that can efficiently activate cytotoxic T lymphocytes inhibit negative regulators will amplify immunotherapy outcome, which however very rare. Herein, a new kind semiconducting polymer (SP) nanoparticles developed, featured with surface-mimicking protein secondary structure (SPSS NPs)...
Abstract The formation of an occlusive thrombus in the blood vessel is main culprit for numerous life-threatening cardiovascular diseases that represent leading cause morbidity and mortality worldwide. Herein, we develop a polymer nanoplatform integrates long-wavelength second near-infrared (NIR-II) photoacoustic imaging-based thrombosis detection antithrombotic activity. We design synthesize semiconducting homopolymer with strong absorption NIR-II region molecular motion boosts photothermal...
Rheumatoid arthritis (RA) severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, representing a pressing public health concern. The pathogenesis of RA includes excessive production proinflammatory cytokines harmful oxygen-derived free radicals, such as nitric oxide (NO), which constitute vital targets for precise diagnosis effective treatment RA. In this study, we introduce an advanced nanoagent that integrates...
Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further...
We report five new complete mitochondrial DNA (mtDNA) genomes of Siberian woolly mammoth ( Mammuthus primigenius ), sequenced with up to 73-fold coverage from extracted hair shaft material. Three the sequences present first mtDNA clade II. Analysis these and 13 recently published demonstrates existence two apparently sympatric clades that exhibit high interclade divergence. The analytical power afforded by analysis reveals a surprisingly ancient coalescence age clades, ≈1–2 million years,...
Supramolecular macrocyclic hosts have long been used in smart materials. However, their triplet emission and regulation at crystal level is rarely studied. Herein, ultralong universal room-temperature phosphorescence (RTP) reported for traditional crown ethers. A supramolecular strategy involving chain length adjustment morphological locking through complexation with K+ was explored as a general method to tune the lifetime solid state. maximum 10-fold increase of after complex formation...