A5062597899- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Quantum Information and Cryptography
- Quantum Mechanics and Applications
- Quantum Computing Algorithms and Architecture
- Cellular Mechanics and Interactions
- Cell Image Analysis Techniques
- Optical Coherence Tomography Applications
- Digital Holography and Microscopy
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Photonic and Optical Devices
- Force Microscopy Techniques and Applications
- Thermography and Photoacoustic Techniques
- Nanoplatforms for cancer theranostics
- Neural Networks and Reservoir Computing
- Noise Effects and Management
- Mechanical and Optical Resonators
- Analytical Chemistry and Sensors
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Advanced Fiber Laser Technologies
- Adaptive optics and wavefront sensing
- Random lasers and scattering media
- Optical Imaging and Spectroscopy Techniques
European Molecular Biology Laboratory
2018-2025
Heidelberg University
2022-2025
European Molecular Biology Laboratory
2017-2025
FENS Kavli Network of Excellence
2025
European Molecular Biology Laboratory
2018-2024
German Center for Lung Research
2022-2024
European Molecular Biology Laboratory
2018-2024
Center for Neurosciences
2024
European Bioinformatics Institute
2022
Heidelberg University
2021
We report the first experimental generation and characterization of a six-photon Dicke state. The produced state shows fidelity F=0.56+/-0.02 with respect to an ideal violates witness detecting genuine six-qubit entanglement by four standard deviations. confirm characteristic properties our resource demonstrate its versatility projecting out four- five-photon states, as well four-photon GHZ W states. also show that states have interesting applications in multiparty quantum networking...
Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is shallow penetration depth. Two-photon microscopic imaging with excitation in longer-wavelength near-infrared (NIR) region (>1100 nm) and emission NIR-I (650–950 good choice to realize deep-tissue high-resolution imaging. Here, we report ultradeep two-photon bioimaging 1300 nm NIR-II (peak ∼810 based on NIR aggregation-induced luminogen (AIEgen). The crab-shaped AIEgen possesses planar...
Abstract Multiphoton microscopy has become a powerful tool with which to visualize the morphology and function of neural cells circuits in intact mammalian brain. However, tissue scattering, optical aberrations motion artifacts degrade imaging performance at depth. Here we describe minimally invasive intravital methodology based on three-photon excitation, indirect adaptive optics (AO) active electrocardiogram gating advance deep-tissue imaging. Our modal-based, sensorless AO approach is...
Abstract Brillouin microscopy can assess mechanical properties of biological samples in a three-dimensional (3D), all-optical and hence non-contact fashion, but its weak signals often lead to long imaging times require an illumination dosage harmful for living organisms. Here, we present high-resolution line-scanning microscope multiplexed fast 3D dynamic processes with low phototoxicity. The improved background suppression resolution, combination fluorescence light-sheet imaging, enables...
We demonstrate phase super-resolution in the absence of entangled states. The key insight is to use inherent time-reversal symmetry quantum mechanics: our theory shows that it possible measure, as opposed prepare, Our approach robust, requiring only photons exhibit classical interference: we experimentally high-visibility with three, four, and six using a standard laser photon counters. six-photon experiment demonstrates best yet reported high visibility resolution.
We demonstrate a new architecture for an optical entangling gate that is significantly simpler than previous realizations, using partially polarizing beam splitters so only single mode-matching condition required. operation of controlled-z in both continuous-wave and pulsed regimes operation, fully characterizing it each case quantum process tomography. also resolving, nondeterministic Bell-state analyzer based on this gate. This ideally suited to guided optics implementations gates.
Abstract Despite investigations for over 70 years, the absolute limits of human vision have remained unclear. Rod cells respond to individual photons, yet whether a single-photon incident on eye can be perceived by subject has fundamental open question. Here we report that humans detect cornea with probability significantly above chance. This was achieved implementing combination psychophysics procedure quantum light source generate states light. We further discover reporting single photon...
In this work, we quantify the mechanical properties of extra-cellular matrix (ECM) in live zebrafish using Brillouin microscopy. Optimization imaging conditions and parameters, combined with careful spectral analysis, allows us to resolve thin ECM distinguish its frequency shift, a proxy for properties, from surrounding tissue. High-resolution mapping further enables direct measurement thickness label-free in-vivo. We find be ~500 nm thick, very good agreement electron microscopy...
Abstract Brillouin microscopy is an emerging optical elastography technique capable of assessing mechanical properties biological samples in a three-dimensional, all-optical and noncontact fashion. The typically weak scattering signal can be substantially enhanced via stimulated (SBS) process; however, current implementations require high pump powers, which prohibit applications to photosensitive or live imaging samples. Here we present pulsed SBS scheme that takes advantage the nonlinearity...
A hallmark of animals is the coordination whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges sessile with a complex canal system for filter-feeding. They undergo resembling "contractions" lead closure water expulsion. Here, we combine live 3D optical coherence microscopy, pharmacology, functional proteomics elucidate sequence detail shape changes, tissues molecular physiology involved, control...