A5013688907- Laser-Matter Interactions and Applications
- Advanced Fiber Laser Technologies
- Pluripotent Stem Cells Research
- Effects and risks of endocrine disrupting chemicals
- Photonic Crystal and Fiber Optics
- Mass Spectrometry Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Laser-Plasma Interactions and Diagnostics
- Advanced Chemical Physics Studies
- Animal testing and alternatives
- Optical Coherence Tomography Applications
- Solid State Laser Technologies
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoacoustic and Ultrasonic Imaging
- Carcinogens and Genotoxicity Assessment
- Reproductive Biology and Fertility
- Immunotoxicology and immune responses
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Animal Genetics and Reproduction
- Toxic Organic Pollutants Impact
- Renal and related cancers
- Fatty Acid Research and Health
- Pharmacological Effects and Toxicity Studies
Texas A&M University
2020-2025
Mitchell Institute
2021-2024
TU Wien
2009-2022
Princeton University
2021
Baylor University
2021
Bridge University
2021
National Institute for Public Health and the Environment
2007-2018
Medical University of Vienna
2017
University of Applied Sciences Technikum Wien
2009-2017
Utrecht University
2010-2016
We demonstrated how the subcycle evolution of electric field light can be used to control motion bound electrons. Results are presented for dissociative ionization deuterium molecules (D2 --> D+ + D), where asymmetric ejection ionic fragment reveals that light-driven intramolecular electronic before dissociation localizes electron on one two ions in a controlled way. The results extend subfemtosecond and provide evidence its usefulness controlling reaction dynamics.
A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily gavage to HBCD dissolved corn oil 8 groups doses ranging between 0 200 mg/kg bw per day (mkd). Evaluation consisted of dose-response analysis calculation a benchmark at the lower 95% one-sided confidence bound (BMDL) predefined critical effect sizes (CESs) 10–20%. The most remarkable findings dose-related effects on thyroid...
A detailed report is presented on the performance of postimplantation rat whole-embryo culture (WEC) test in a European Centre for Validation Alternative Methods (ECVAM)-sponsored formal validation study three vitro tests embryotoxicity. Twenty coded chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly basis their vivo effects animals and/or humans, were tested four laboratories. The outcome showed that WEC can be considered to scientifically validated test, which ready...
We have developed the first (to our knowledge) femtosecond Tm-fiber-laser-pumped Ho:YAG room-temperature chirped pulse amplifier system delivering scalable multimillijoule, multikilohertz pulses with a bandwidth exceeding 12 nm and average power of 15 W. The recompressed 530 fs are suitable for broadband white light generation in transparent solids, which makes source ideal both pumping seeding optical parametric amplifiers operating mid-IR spectral range.
We demonstrate a four-stage optical parametric chirped-pulse amplification system that delivers carrier-envelope phase-stable ~1.5 μm pulses with energies up to 12.5 mJ before recompression. The is based on fusion of femtosecond diode-pumped solid-state Yb technology and picosecond 100 Nd:YAG pump laser. Pulses 62 nm bandwidth are recompressed 74.4 fs duration close the transform limit. To show way toward terawatt-peak-power single-cycle IR source, we self-compression 2.2 down 19.8 in single...
Sub-femtosecond control of the electron emission in above-threshold ionization rare gases Ar, Xe and Kr intense few-cycle laser fields is reported with full angular resolution. Experimental data that were obtained velocity-map imaging technique are compared to simulations using strong-field approximation (SFA) time-dependent Schrödinger equation (TDSE) calculations. We find a pronounced asymmetry both energy distributions critically depends on carrier-envelope phase (CEP) field. The...
We observe an optical signature induced by the modulation of electron density inside a bulk transparent solid that is quasiperiodically ionized on attosecond time scale electric field peaks focused few-cycle laser pulse. The emitted signal resulting from ionization dynamics spatially, temporally and spectrally isolated concomitant responses through use noncollinear pump-probe technique. method holds promise for developing metrology solids, in which, unlike established gases surfaces, direct...
Self-channeling of few-cycle laser pulses in helium at high pressure generates coherent light supercontinua spanning the range 270-1000 nm, with highest efficiency demonstrated to date. Our results open door synthesis powerful waveforms shaped within carrier field oscillation cycle and hold promise for generation single-cycle limit.
A detailed report is presented on the performance of rat limb bud micromass (MM) test in a European Centre for Evaluation Alternative Methods (ECVAM)-sponsored formal validation study three vitro tests embryotoxicity. Twenty coded chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly basis their vivo effects animals and/or humans, were tested four laboratories. The outcome showed that MM an experimentally validated test, which holds promise use identifying but needs to be...
Abstract We demonstrate how the waveform of light can be used to control a molecular dissociation by steering and localisation electrons. Experimental results have been obtained for dissociative ionisation homonuclear heteronuclear hydrogen derivates D2 HD. Asymmetric ejection ionic fragments reveals that light-driven electronic motion prior localises electron on one two ions in diatomic controlled way. Extension these transfer complex molecules suggests new paradigm controlling...
We introduce a method to extract the photoacoustic (PA) signal from phase time evolution of an optical coherence tomography (OCT) swept source spectral sweep. This all-optical detection is achieved in noncontact fashion directly on sample surface by using its specular reflection. High-speed measurement and referencing allow for close shot noise limited phase-sensitive detection. It offers simple way perform OCT PA imaging sharing same system components.
We have experimentally detected optical harmonics that are generated due to a tunneling-ionization-induced modulation of the electron density. The signature tunneling can be isolated from concomitant responses by using noncollinear pump-probe setup. Whereas previously demonstrated tools for attosecond metrology gases, plasmas, and surfaces rely on direct detection charged particles, background-free time-resolved signal, which uniquely originates tunneling, offers an interesting alternative...
Rat postimplantation whole-embryo culture (WEC) is a promising alternative test for the assessment of developmental toxicity. Toxicogenomic-based approaches may improve predictive ability WEC model by providing means to identify compound-specific mechanistic responses associated with embryotoxicity in vivo. Furthermore, alterations gene expression serve as sensitive, objective, and robust marker, which precedes observation classical toxicity endpoints time. In this study, combination...