A5057974924- Advanced Fluorescence Microscopy Techniques
- Diamond and Carbon-based Materials Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Cell Image Analysis Techniques
- Optical Imaging and Spectroscopy Techniques
- Random lasers and scattering media
- Quantum optics and atomic interactions
- Advanced Fiber Laser Technologies
- Optical Coherence Tomography Applications
- Receptor Mechanisms and Signaling
- Electronic and Structural Properties of Oxides
- Particle Detector Development and Performance
- demographic modeling and climate adaptation
- High-pressure geophysics and materials
- Vestibular and auditory disorders
- Particle physics theoretical and experimental studies
- Zebrafish Biomedical Research Applications
- Neurotransmitter Receptor Influence on Behavior
- Particle Accelerators and Free-Electron Lasers
- Digital Holography and Microscopy
- Sleep and Wakefulness Research
- Mechanical and Optical Resonators
- Force Microscopy Techniques and Applications
- Ion-surface interactions and analysis
Rockefeller University
2017-2024
Research Institute of Molecular Pathology
2015-2017
Vienna Center for Quantum Science and Technology
2011-2015
TU Wien
2011-2015
University of Vienna
2015
Max Perutz Labs
2015
Institute of High Energy Physics
2007-2008
Austrian Academy of Sciences
2006
The Compact Muon Solenoid (CMS) detector is described. operates at the Large Hadron Collider (LHC) CERN. It was conceived to study proton-proton (and lead-lead) collisions a centre-of-mass energy of 14 TeV (5.5 nucleon-nucleon) and luminosities up 1034 cm−2 s−1 (1027 s−1). At core CMS sits high-magnetic-field large-bore superconducting solenoid surrounding an all-silicon pixel strip tracker, lead-tungstate scintillating-crystals electromagnetic calorimeter, brass-scintillator sampling hadron...
We report strong coupling between an ensemble of nitrogen-vacancy center electron spins in diamond and a superconducting microwave coplanar waveguide resonator. The characteristic scaling the collective strength with square root number emitters is observed directly. Additionally, we measure hyperfine to 13C nuclear spins, which first step towards quantum memory. Using dispersive shift cavity resonance frequency, relaxation time T1 NV at millikelvin temperatures non-destructive way.
Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and vivo single-neuron calcium imaging, we found that drugs augment dopaminoceptive ensemble activity nucleus accumbens (NAc) disorganize overlapping responses natural rewards a cell type–specific manner. Combining FOS-Seq, CRISPR-perturbation, single-nucleus RNA sequencing, identified Rheb as molecular substrate regulates...
Physics and information are intimately connected, the ultimate processing devices will be those that harness principles of quantum mechanics. Many physical systems have been identified as candidates for processing, but none them immune from errors. The challenge remains to find a path experiments today reliable scalable computer. Here, we develop an architecture based on simple module comprising optical cavity containing single negatively-charged nitrogen vacancy centre in diamond. Modules...
We experimentally demonstrate a simple yet versatile optimal quantum control technique that achieves tailored robustness against qubit inhomogeneities and errors while requiring minimal bandwidth. apply the to nitrogen-vacancy (NV) centers in diamond verify its performance using process tomography. In wide-field NV center magnetometry scenario, we achieve homogeneous sensitivity across 33% drop amplitude, improve by up 2 orders of magnitude for normalized detuning as large 40%, achieving...
We study experimentally and theoretically a dense ensemble of negatively charged nitrogen-vacancy centers in diamond coupled to high $Q$ superconducting coplanar waveguide cavity mode at low temperature. The are modeled as effective spin one defects with inhomogeneous frequency distribution. For large enough the magnetic coupling collective dominates losses broadening system exhibits well resolved normal splitting probe transmission spectra. use several theoretical approaches model spectra...
A major challenge in neuroscience is to sample large-scale neuronal activity at high speed and resolution. While calcium (Ca2+) imaging allows high-resolution optical read-out of activity, it remains challenging speed, as most available microscopes provide a trade-off between the size acquisition volume. One promising method that avoids rate volume light-field microscopy which full 3D profile an object imaged simultaneously, thereby offering cost reduced spatial Here we introduce speckle...
The nucleus accumbens (NAc) is a canonical reward center that regulates feeding and drinking but it not known whether these behaviors are mediated by same or different neurons. We employed two-photon calcium imaging in awake, behaving mice found during the appetitive phase, both hunger thirst sensed nearly identical population of individual D1 D2 neurons NAc respond monophasically to food cues fasted animals water dehydrated animals. During consummatory we identified three distinct neuronal...
Recently, fluorescence-based optical techniques have emerged as a powerful tool to probe information in the mammalian brain. However, tissue heterogeneities prevent clear imaging of deep neuron bodies due light scattering. While several up-to-date approaches based on ballistic allow retrieve at shallow depths inside brain, non-invasive localization and functional depth still remains challenge. It was recently shown that signals from time-varying fluorescent emitters located behind scattering...
The electronics of the First Level Global Trigger (GT) for CMS experiment is described. It last stage Level-1 trigger system and decides every LHC bunch crossing whether to reject or accept a physics event further evaluation by High Trigger. receives objects from Calorimeter Muon applies in parallel up 128 requirements, so-called 'Algorithms'. In addition, 64 'Technical Trigger' signals can be used either events. Algorithm Technical bits are then combined Final_OR signal start readout...
Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires recording of population activity via technologies that are compatible with unconstrained animal behavior. However, realizations cellular resolution head-mounted microscopes for mice have been based on conventional microscope designs feature various forms ad-hoc miniaturization and weight reduction measures necessary compatibility the weight-limits free As a result, they typically remained limited small...
Abstract Addiction prioritizes drug use over innate needs by “hijacking” brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we find drugs of abuse augment ensemble activity the nucleus accumbens (NAc) disorganize overlapping responses to natural rewards a cell-type-specific manner. Combining “FOS-Seq”, CRISPR-perturbations, snRNA-seq, identify Rheb as shared molecular substrate regulates...
We created dense ensembles of negatively charged nitrogen-vacancy (NV-) centers in diamond by neutron and electron irradiation for applications hybrid quantum systems magnetometry. characterize fluorescence intensity, optical coherence properties the resulting defects confocal microscopy, UV/Vis FTIR spectroscopy, optically detected magnetic resonance small angle X-ray scattering. find highest densities NV- at fluences on order 10^17 cm^-2 doses 10^18 cm^-2, with spin linewidths 6 MHz. Lower...
We demonstrate a magnetometry technique using nitrogen-vacancy centres in diamond which makes use of coherent two-photon transitions. find that the sensitivity to magnetic fields can be significantly improved isotopically purified diamond. Furthermore, long-term stability field measurements is enhanced, thereby reducing minimum detectable variations for both quasi-static and periodic fields. The method useful sensing applications as spin qubit manipulation technique.
Functional imaging of neuronal activity in awake animals, using a combination fluorescent reporters and various types microscopy modalities, has become an indispensable tool neuroscience. While modalities based on one-photon (1P) excitation parallel (camera-based) acquisition have been successfully used for more transparent samples, when mammalian brain tissue, due to their scattering properties, two-photon (2P) systems are necessary. In 2P microscopy, the longer wavelengths reduce amount...