Radiotherapy or accidental exposure to high-dose radiation can cause severe damage healthy organs. The gastrointestinal (GI) tract is a radiation-sensitive organ of the body. intestinal barrier first line defense in GI tract, and consists mucus secreted by goblet cells monolayer epithelium. Intestinal stem (ISCs) help maintenance function after injury regulating efficient regeneration Wnt/β-catenin pathway plays critical role maintaining epithelium regulates ISC self-renewal. Metformin most...

SUMMARY The brain’s remarkable properties arise from collective activity of millions neurons. Widespread application dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting computations. However, what would the biological utility such a redundant and metabolically costly encoding scheme is appropriate resolution scale recording understand brain function? Imaging one million neurons at cellular...

Ticks were collected from 35 animals 5 provinces and 3 metropolitan cities during 2012. also by tick drag 4 sites in Gyeonggi-do (2) Jeollabuk-do Provinces. A total of 612 ticks belonging to 6 species genera mammals a bird (n=573) (n=39). Haemaphyalis longicornis (n=434) was the most commonly tick, followed H. flava (158), Ixodes nipponensis (11), Amblyomma testudinarium (7), japonica (1), formosensis (1). all animal hosts examined. For (n>1), highest Tick Index (TI) observed for domestic...

Radiation-induced enteropathy remains a major complication after accidental or therapeutic exposure to ionizing radiation. Recent evidence suggests that intestinal microvascular damage significantly affects the development of radiation enteropathy. Mesenchymal stem cell (MSC) therapy is promising tool regenerate various tissues, including skin and intestine. Further, photobiomodulation (PBM), low-level light therapy, can accelerate wound healing, especially by stimulating angiogenesis, cells...

The skin is impacted by every form of external radiation therapy. However, effective therapeutic options for severe, acute radiation-induced reactions are limited. Although platelet-rich plasma (PRP) known to improve cutaneous wound healing, its effects in the context high-dose irradiation still poorly understood.We investigated regenerative functions PRP subjecting dorsal mice local (40 Gy) and exposing HaCaT cells gamma rays (5 Gy). benefits were gauged size, histologic features,...

Indole-3-acetic acid (IAA) is the most common plant hormone of auxin class and known to have many effects including cell proliferation enhancement antioxidant property. However, no study has revealed its defensive against oxidative toxicity in human dental pulp stem cells (hDPSCs). In this study, we investigated IAA on hydrogen peroxide- (H2O2-) induced hDPSCs. H2O2-induced cytotoxicity was attenuated after treatment. Cell cycle analysis using FACS showed that damaged increased number...

Abstract Lung epithelial cells serve as the first line of defense against various inhaled pollutant particles. To investigate adverse health effects organic components fine particulate matter (PM 2.5 ) collected in Seoul, South Korea, we selected 12 PM samples from May 2016 to January 2017 and evaluated compounds on inflammation, cellular aging, macroautophagy human lung isolated directly healthy donors. Organic extracts specifically induced neutrophilic chemokine interleukin-8 expression...

Exposure to high-dose radiation, such as after a nuclear accident or radiotherapy, elicits severe intestinal damage and is associated with high mortality rate. In treating patients exhibiting radiation-induced dysfunction, countermeasures radiation are required. principle, the cellular event underlying gastrointestinal syndrome stem cell (ISC) apoptosis in crypts. High-dose irradiation induces loss of ISCs impairs barrier function, including epithelial regeneration integrity. Notch signaling...

Two-photon microscopy together with genetically encodable calcium indicators has emerged as a standard tool for high-resolution imaging of neuroactivity in scattering brain tissue. However, its various realizations have not overcome the inherent tradeoffs between speed and spatiotemporal sampling principled manner which would be necessary to enable, amongst other applications, mesoscale volumetric recording at cellular resolution compatible resolving transients. Here, we introduce Light...

Background: Non-small cell lung cancer (NSCLC) is difficult to treat successfully. This intractability mainly due the progressing through invasion, metastasis, chemotherapeutic resistance and relapse. Stemness has been linked various steps of progression in a variety tumors, yet little known regarding its role NSCLC. Purpose: In this study, we sought determine SOX2, master regulator pluripotency, growth extracellular matrix (ECM)-detached cells during progression. Methods: We established...

Delayed wound healing after radiation exposure can cause serious cutaneous damage, and its treatment is a major clinical challenge. Although mesenchymal stem cells (MSCs) have emerged as promising therapeutic agent in regenerative medicine, they alone do not produce satisfactory effects combined injury (CRWI) model. Here, we investigated the effect of umbilical cord blood-derived (UCB)-MSCs platelet-rich plasma (PRP) on CRWI mouse First, assessed release cytokines from UCB-MSCs cultured with...

Background and Aims: Radiation-induced enteropathy is frequently observed after radiation therapy for abdominal pelvic cancer or occurs secondary to accidental exposure. The acute effects of irradiation on the intestine might be attributed inhibition mitosis in crypts, as loss proliferative functions impairs development small intestinal epithelium its barrier function. Especially, oxidative damage epithelial cells a key event initiation progression radiation-induced enteropathy. Pravastatin...

In this paper, a new efficient and accurate analytical eye-diagram determination technique for interconnect lines is presented. The simplest input test signal model the intersymbol interference analysis of high-speed data links mathematically formulated. Since patterns eye boundaries are determined analytically, it considered very convenient efficient. proposed shows excellent agreement with SPICE-based simulation in both height jitter, i.e., within 5% error nondiscontinuous paths 10%...

A high-frequency fine-pitched (i.e., very narrow line width) thin-film transmission (TL) characterization technique is presented. new dielectric permittivity determination for TL structures developed. Multi-layered mixed materials are then accurately characterized in a broad frequency band, to be followed by the characterization. For experiments, various lengths of and extra patterns were designed fabricated using both 0.18-μm SK Hynix CMOS process 0.13-μm Samsung process. S-parameters test...

Salivary gland stem cells (SGSCs) are potential cell sources for the treatment of salivary diseases. The control survival is an essential factor applying to regenerative medicine or cell-based research. purpose this study was investigate effects ROCK inhibitor Y-27632 on SGSCs and its underlying mechanisms. were isolated from mouse submandibular glands cultured in suspension. Treatment with restored viability that significantly decreased during isolation subsequent culture. upregulated...

Abstract Intestinal organoids have recently emerged as an in vitro model relevant to the gut system owing their recapitulation of native intestinal epithelium with crypt–villus architecture. However, it is unclear whether reflect physiology vivo stress response. Here, we systemically investigated radiation response and animal models using mesenchymal stem cell‐conditioned medium (MSC‐CM), which contains secreted paracrine factors. Irradiated exhibited sequential induction viability loss...

Abstract Background Bone has important functions in the body. Several researchers have reported that polysaccharides and lipopolysaccharide derived from microbes can promote osteogenic differentiation of stem cells. Enterococcus faecium, a lactic acid bacterium (LAB), produces several bioactive metabolites been widely applied food nutraceutical industries. The exopolysaccharide (EPS) LAB also extensively examined for its postbiotic effects vivo vitro functionalities. However, studies on...