A5100333895- Healthcare and Venom Research
- Food Quality and Safety Studies
- Effects of Radiation Exposure
- Nasal Surgery and Airway Studies
- Musculoskeletal pain and rehabilitation
- Phytochemicals and Antioxidant Activities
- Mesenchymal stem cell research
- Traditional Chinese Medicine Studies
- Cleft Lip and Palate Research
- Spine and Intervertebral Disc Pathology
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Skin Protection and Aging
- Sinusitis and nasal conditions
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Facial Nerve Paralysis Treatment and Research
- Pharmacology and Obesity Treatment
- Medical Research and Treatments
- Head and Neck Surgical Oncology
- Infectious Encephalopathies and Encephalitis
- Gastrointestinal disorders and treatments
- Retinal Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Pharmacological Effects and Toxicity Studies
Korea Institute of Radiological and Medical Sciences
2007-2024
Konkuk University
2022-2023
Electronics and Telecommunications Research Institute
2021-2023
Konkuk University Medical Center
2023
Kosin University
2022-2023
Sookmyung Women's University
2023
Wonkwang University
2022
Avixgen (South Korea)
2021
University of Pittsburgh
2021
Kyung Hee University Medical Center
2021
The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). role TLR7 in pathogenesis enhanced when the regulatory TLR9 absent. signaling plasmacytoid DCs (pDC) generally thought to be IFN response disease pathology; however, cell types which acts mediate have not been distinguished. To address this, we selectively deleted either CD11c+ cells or CD19+ cells; using TLR7-floxed allele, created on lupus-prone MRL/lpr background, along with...
Metastasis is a challenging clinical problem and the primary cause of death in breast cancer patients. However, there no therapeutic agent against metastasis cells. Here we report that phloroglucinol, natural phlorotannin component brown algae suppresses metastatic ability Treatment with phloroglucinol effectively inhibited mesenchymal phenotypes basal type cells through downregulation SLUG without causing cytotoxic effect. Importantly, decreased inhibition PI3K/AKT RAS/RAF-1/ERK signaling....
Radiation-induced enteropathy remains a major complication after accidental or therapeutic exposure to ionizing radiation. Recent evidence suggests that intestinal microvascular damage significantly affects the development of radiation enteropathy. Mesenchymal stem cell (MSC) therapy is promising tool regenerate various tissues, including skin and intestine. Further, photobiomodulation (PBM), low-level light therapy, can accelerate wound healing, especially by stimulating angiogenesis, cells...
Papillary thyroid cancer (PTC) is the most prevalent histological type of (TC) worldwide. Although tumor metastasis occurs in regional lymph nodes, distant (DM) may also occur. Radioactive iodine (RAI) therapy an effective treatment for TC; however, resistance to RAI patients with DM. Therefore, this study, we investigated efficacy DM-related biomarkers as therapeutic targets PTC therapy. ABCA1 expression was higher aggressive BCPAP cells than other terms migration and invasion capacity. The...
Triple-negative breast cancers (TNBCs) are characterized by high rates of recurrence and poor clinical outcomes. Deregulated E3 ligases involved in cancer pathogenesis progression, but the underlying mechanisms unclear. Here, we find that F-box leucine-rich repeat protein 16 (FBXL16) acts as a tumor suppressor TNBCs. FBXL16 directly binds to HIF1α induces its ubiquitination degradation, regardless microenvironment, resulting blockade HIF1α-mediated epithelial-mesenchymal transition (EMT)...
O046 / #556 Topic: AS02 - Animal Models ABSTRACT CONCURRENT SESSION 07: COGNITION IMPAIRMENT IN SLE — RECENT ADVANCEMENT AND EMERGING RESEARCH 23-05-2025 1:40 PM 2:40 Background/Purpose Unclear mechanisms underlying diffuse NPSLE (psychosis, anxiety disorder, cognitive dysfunction) may lead to the devastating impact of this disease on patients’ health-related quality life, representing a major unmet need in field. In prior work, systemic depletion CD4+ T cells ameliorated both and behavior...
Purpose: The purpose of this study was to investigate the relationship between ocular perfusion pressure (OPP) and subfoveal choroidal thickness (CT) in eyes with early age-related macular degeneration (AMD) or without reticular pseudodrusen (RPD). Methods: We evaluated clinical history, blood parameters, fundus photography, optical coherence tomography images consecutive patients AMD. calculated mean OPP from intraocular pressure. Results: included 103 patients, classifying 45 as RPD group...
Radiation exposure severely damages the hematopoietic system. Although several radio-protectors have been proposed to prevent radiation-induced damage, most agents limited efficacy. In present study, we investigated whether mesenchymal stem cells (MSCs) could contribute expansion of and mitigate injury in vitro vivo. We found that co-culture with MSCs promoted progenitor/stem cell (HPSCs) maintenance by providing a bone marrow-like microenvironment. addition, showed prevented damage HPSCs,...
Although chemo- or radiotherapy is usually performed in patients with colorectal cancer, the response highly variable locally rectal cancer. Therefore, additional studies are needed on predictable markers and molecular mechanisms of radiotherapy. Y box binding protein 1 (YB1) an oncoprotein that aberrantly expressed many cancers, including However, to date there no targeting agents strategies inhibit YB1 expression. Here, we investigate oncogenic function cancer methods control its We...
We identified cytochrome P450 (P450) isozymes that are involved in the formation of two active sibutramine (<i>N</i>-{1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutyl}-<i>N</i>,<i>N</i>-dimethylamine) metabolites, M1 (<i>N</i>-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-<i>N</i>-methylamine) and M2 (1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine), humans using a combination chemical inhibition, correlation analyses human liver microsomes (HLMs), activity assays recombinant P450s....
Shiitake mushroom (SM; Lentinus edodes) are cultivated and consumed in many Asian countries including Vietnam, China, Japan, Korea, Thailand. In Asia, SM mainly dried used as flavoring. The aim of this study was to compare the effects created with different drying processes, such oven-dried sun-dried, on antioxidative antigenotoxic effects. Raw were extracted acetone, ethanol, methanol, hot water. antioxidant evaluated by determining total phenolic content, DPPH radical scavenging activity...
Purpose . Radiation-induced lung fibrosis (RILF) is a serious late complication of radiotherapy. In vitro studies have demonstrated that pentoxifylline (PTX) has suppressing effects in extracellular matrix production fibroblasts, while the antifibrotic action PTX alone using clinical dose yet unexplored. Materials and Methods We used micro-computed tomography (micro-CT) histopathological analysis to evaluate rat model RILF. Results Micro-CT findings showed density, volume loss, mediastinal...
Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and treatment delays, lowering chemotherapy efficacy survival rate. Thus, rapid recovery continuous maintenance of platelet count during cycles are crucial with CIT. Thrombopoietin (TPO) its receptor, myeloid proliferative leukemia (MPL) protein, play major role production. Although several MPL agonists have been developed regulate...
Therapeutic hypothermia (TH) has rarely been utilized as an adjunct to anticonvulsants in treating patients with refractory convulsive status epilepticus (CSE). However, determining the effectiveness of TH CSE is difficult due unavoidable use sedative drugs manage hypothermia. Additionally, not studied non-convulsive (NCSE). Here, we report successful without additional a patient temporal lobe epilepsy and NCSE. A 46-year-old man was referred neurology department because recurrent seizure...
Background: Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that overexpressed in several types of epithelial cancers, and suggested to be associated with an unfavorable prognosis.BRAF mutations are the most common genetic alteration papillary thyroid carcinoma (PTC).We evaluated correlation between TROP2 expression BRAF mutation PTC.Methods: First, we carried out pyrosequencing for immunohistochemistry tissue microarray consisting 52 PTC cases.Membranous...
The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role thyroid tissues has not been fully elucidated. Therefore, this study was conducted to characterize the expression of papillary cancer (PTC) cells anaplastic (ATC) cells.Expression activated Notch1 ATC PTC paraffin-embedded determined by immunohistochemistry. small interfering RNA techniquewas employed knock down cell lines.The higher cases than cases. Inhibition significantly...