A5100761862- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Acne and Rosacea Treatments and Effects
- Wound Healing and Treatments
- Microtubule and mitosis dynamics
- Dermatologic Treatments and Research
- RNA modifications and cancer
- Oral health in cancer treatment
- Genital Health and Disease
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Colorectal Cancer Treatments and Studies
- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Laser Applications in Dentistry and Medicine
- NF-κB Signaling Pathways
- Biomarkers in Disease Mechanisms
Korea Institute of Radiological and Medical Sciences
2017-2021
Background and Aims: Radiation-induced intestinal injury occurred in application of radiotherapy for abdominal pelvic cancers or nuclear accidents. enteritis may be considered an ideal model gastrointestinal inflammation. The endothelium is a crucial component inflammation, the endothelial dysfunction following radiation exposure induces proinflammatory response progression enteritis. Baicalein (5,6,7-trihydroxyflavonoid) flavonoid from Scutellaria baicalensis used oriental herbal medicine....
Current lung cancer treatments are far from satisfactory; thus, finding novel treatment targets is crucial. We recently identified procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3), which involved in fibrosis and tissue remodeling as a radioresistance-related protein cells; however, its mechanism unclear. In this study, we designed human PLOD3-specific short interfering (si)RNAs tested their effects on tumor growth inhibition vitro vivo. PLOD3 knockdown overcame chemoresistance...
Radiation-induced enteropathy remains a major complication after accidental or therapeutic exposure to ionizing radiation. Recent evidence suggests that intestinal microvascular damage significantly affects the development of radiation enteropathy. Mesenchymal stem cell (MSC) therapy is promising tool regenerate various tissues, including skin and intestine. Further, photobiomodulation (PBM), low-level light therapy, can accelerate wound healing, especially by stimulating angiogenesis, cells...
The skin is impacted by every form of external radiation therapy. However, effective therapeutic options for severe, acute radiation-induced reactions are limited. Although platelet-rich plasma (PRP) known to improve cutaneous wound healing, its effects in the context high-dose irradiation still poorly understood.We investigated regenerative functions PRP subjecting dorsal mice local (40 Gy) and exposing HaCaT cells gamma rays (5 Gy). benefits were gauged size, histologic features,...
Radiation-induced colitis is a common clinical problem associated with radiotherapy and accidental exposure to ionizing radiation. Goblet cells play pivotal role in the intestinal barrier against pathogenic bacteria. Rebamipide, an anti-gastric ulcer drug, has effects promote goblet cell proliferation. The aim of this study was investigate whether radiation-induced colonic injury could be alleviated by rebamipide.This orally administered rebamipide for 6 days mice, which were subjected 13 Gy...
Delayed wound healing after radiation exposure can cause serious cutaneous damage, and its treatment is a major clinical challenge. Although mesenchymal stem cells (MSCs) have emerged as promising therapeutic agent in regenerative medicine, they alone do not produce satisfactory effects combined injury (CRWI) model. Here, we investigated the effect of umbilical cord blood-derived (UCB)-MSCs platelet-rich plasma (PRP) on CRWI mouse First, assessed release cytokines from UCB-MSCs cultured with...
Background and Aims: Radiation-induced enteropathy is frequently observed after radiation therapy for abdominal pelvic cancer or occurs secondary to accidental exposure. The acute effects of irradiation on the intestine might be attributed inhibition mitosis in crypts, as loss proliferative functions impairs development small intestinal epithelium its barrier function. Especially, oxidative damage epithelial cells a key event initiation progression radiation-induced enteropathy. Pravastatin...
Kinesins act as molecular microtubule-dependent motor proteins and have various important cellular functions related to cell division, intracellular transport, membrane trafficking. However, the function of kinesin light chain 4 (KLC4) in cancer, especially radioresistance, has not been previously described. Thus, we investigated KLC4 lung cancer cells radioresistant R-H460 by analyzing alterations radiosensitivity after gene knockdown with siRNA evaluating phenotypes xenograft tumor growth....
Radiation-induced skin injury can take the form of serious cutaneous damage and have specific characteristics. Asymptomatic periods are classified as latent stage. The barrier plays a critical role in modulation permeability hydration protects body against harsh external environment. However, an analysis on dysfunction radiation exposure stage has not been conducted. Thus, we investigated whether is impaired by irradiation aimed to identify molecules involved dysfunction. We analyzed...
Abstract Intestinal organoids have recently emerged as an in vitro model relevant to the gut system owing their recapitulation of native intestinal epithelium with crypt–villus architecture. However, it is unclear whether reflect physiology vivo stress response. Here, we systemically investigated radiation response and animal models using mesenchymal stem cell‐conditioned medium (MSC‐CM), which contains secreted paracrine factors. Irradiated exhibited sequential induction viability loss...
Abstract The poor therapeutic efficacy of non-small cell lung cancer (NSCLC) is partly attributed to the acquisition chemoresistance. To investigate mechanism underlying this resistance, we examined potential link between kinesin light chain 4 (KLC4), which have previously reported be associated with radioresistance in NSCLC, and sensitivity chemotherapy human lines. KLC4 protein levels cells correlated degree chemoresistance cisplatin treatment. Furthermore, silencing enhanced cytotoxic...
To improve the poor survival rate of lung cancer patients, we investigated role HDGF-related protein 3 (HRP-3) as a potential biomarker for cancer. The expression endogenous HRP-3 in human tissues and xenograft tumor models is indicative its clinical relevance Additionally, demonstrated that directly binds to E2F1 promoter on chromatin. Interestingly, depletion A549 cells impedes binding promoter; this turn hampers interaction between Histone H3/H4 HDAC1/2 promoter, while concomitantly...
Abstract: Radiation-induced skin injury can be a serious cutaneous damage and have specific characteristics. Asymptomatic periods are classified as the latent stage. The barrier plays critical role in modulation of permeability hydration protects body against harsh external environment. However, an analysis on dysfunction radiation exposure stage has not been conducted. Thus, we investigated whether is impaired by irradiation aimed to identify molecules involved dysfunction. We analyzed...