A5100350575- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Nanoplatforms for cancer theranostics
- MRI in cancer diagnosis
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Magnetism in coordination complexes
- Nanocluster Synthesis and Applications
- Marine and Coastal Research
- Effects of Radiation Exposure
- Advanced Sensor and Energy Harvesting Materials
- Plant Virus Research Studies
- Neuroscience and Neuropharmacology Research
- Boron Compounds in Chemistry
- Energetic Materials and Combustion
- Luminescence and Fluorescent Materials
- Carcinogens and Genotoxicity Assessment
- Medical Imaging Techniques and Applications
- Porphyrin and Phthalocyanine Chemistry
- Maritime Transport Emissions and Efficiency
- Cell death mechanisms and regulation
- Metal-Organic Frameworks: Synthesis and Applications
- Plant Disease Resistance and Genetics
- Alzheimer's disease research and treatments
- Thermal and Kinetic Analysis
Seoul National University
2014-2025
Korea Institute of Materials Science
2024
Hanbat National University
2020-2024
Korea Institute of Radiological and Medical Sciences
2012-2024
Kangwon National University
2024
Yonsei University
2014-2024
Kyungpook National University
2008-2022
Korea Maritime Institute
2022
Chungbuk National University
2021
Chungnam National University
2020
This paper describes a sequential doping/dedoping method for the enhancement of thermoelectric properties organic semiconductor that also permits fabrication transparent and flexible nanofilms. allows precise control oxidation level without deterioration film surface defects.
This study presents a method to prepare stretchable, conductive, water-permeable, and recyclable hybrid films using hydroxyethyl cellulose PEDOT:PSS for eco-friendly sensors, with high sensitivity, low power consumption, hysteresis.
A novel manganese(II) complex based on an ethylenediaminetetraacetic acid (EDTA) coordination cage bearing a benzothiazole aniline (BTA) moiety (Mn-EDTA-BTA) was designed and synthesized for use as liver-specific MRI contrast agent with high chelation stability. In addition to forming hydrophilic, stable Mn2+, this new Mn chelate rapidly taken up by liver hepatocytes excreted the kidneys biliary system. The kinetic inertness R1 relaxivity of were much higher than those mangafodipir trisodium...
Radiotherapy or accidental exposure to high-dose radiation can cause severe damage healthy organs. The gastrointestinal (GI) tract is a radiation-sensitive organ of the body. intestinal barrier first line defense in GI tract, and consists mucus secreted by goblet cells monolayer epithelium. Intestinal stem (ISCs) help maintenance function after injury regulating efficient regeneration Wnt/β-catenin pathway plays critical role maintaining epithelium regulates ISC self-renewal. Metformin most...
This study reports the synthesis, characterization, and photodynamic therapy activity of two orthogonal BODIPY dimers functionalized with TPP cations for mitochondrial targeting.
This study aims to compare the effectiveness of three magnetic resonance angiography (MRA) sequences-Time-of-Flight (TOF), Phase-Contrast (PC), and Time-Resolved Imaging Contrast Kinetics (TRICKS)-in visualizing cerebral arteries veins in dogs. The goal is determine most suitable MRA sequence for improving diagnostic accuracy canine imaging. Five healthy adult beagles underwent imaging using a 1.5-T MRI system. Quantitative measures, including signal-to-noise ratio (SNR) contrast-to-noise...
Papillary thyroid cancer (PTC) is the most prevalent histological type of (TC) worldwide. Although tumor metastasis occurs in regional lymph nodes, distant (DM) may also occur. Radioactive iodine (RAI) therapy an effective treatment for TC; however, resistance to RAI patients with DM. Therefore, this study, we investigated efficacy DM-related biomarkers as therapeutic targets PTC therapy. ABCA1 expression was higher aggressive BCPAP cells than other terms migration and invasion capacity. The...
This work presents an ultra-wideband conformal meandered loop antenna for wireless capsule endoscopy applications. The proposed surrounds the outer wall of a capsule, so that inner space can be used by battery and other electrical optical components. Fabricated on flexible substrate, has diameter 10 mm height 14 when wrapped around cylindrical capsule. achieves ultra-wide impedance bandwidth 200 MHz–2.05 GHz (164% fractional bandwidth), which provides sufficient coverage medical implant...
In this study, we designed and synthesized a highly stable manganese (Mn2+)-based hepatobiliary complex by tethering an ethoxybenzyl (EOB) moiety with ethylenediaminetetraacetic acid (EDTA) coordination cage as alternative to the well-established gadolinium (Gd3+) chelates evaluated its usage T1 magnetic resonance imaging (MRI) contrast agent (CA). This new exhibits higher r1 relaxivity (2.3 mM–1 s–1) than clinically approved Mn2+-based Mn-DPDP (1.6 at 1.5 T. Mn-EDTA-EOB shows much kinetic...
Polyacrylic acid (PAA)-coated lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability good biocompatibility were synthesized, characterized, investigated as a new class of negative (T2) magnetic resonance imaging (MRI) contrast agents at MR fields. Their r2 values appreciable 3.0 T field higher 9.4 field, whereas their r1 negligible all fields, indicating exclusive induction T2 relaxations T1 relaxations. effectiveness MRI fields was confirmed from strong...
Magnetic resonance imaging (MRI) is increasingly used to diagnose focal and diffuse liver disorders. Despite their enhanced efficacy, liver-targeted gadolinium-based contrast agents (GBCAs) raise safety concerns owing the release of toxic Gd3+ ions. A π-conjugated macrocyclic chelate, Mn-NOTA-NP, was designed synthesized as a non-gadolinium alternative for liver-specific MRI. Mn-NOTA-NP exhibits an r1 relaxivity 3.57 mM-1 s-1 in water 9.01 saline containing human serum albumin at 3 T, which...
Advanced photodynamic therapy requires photosensitizers with targeting, diagnostic, and therapeutic properties. To fulfill this multifunctionality, we report the synthesis of two triphenylphosphonium (TPP)-functionalized boron-dipyrromethene (BODIPY) dyes, TPPB-H TPPB-Br, which incorporate a hydrogen atom dibrominated vinyl moiety at 6-position BODIPY core, respectively. The heavy-atom effect moderately heavy bromine atoms allowed TPPB-Br to achieve proper balance between toxic singlet oxygen (
Reelin, an extracellular glycoprotein has important role in the proper migration and positioning of neurons during brain development. Lack reelin causes not only disorganized lamination cerebral cerebellar cortex but also malpositioning mesencephalic dopaminergic (mDA) neurons. However, accurate mDA is fully elucidated. In this study, reelin-deficient reeler mice exhibited a significant loss substantia nigra pars compacta (SNc) severe alteration cell distribution retrorubal field (RRF). This...
Pluripotent stem cells (PSC) are promising resources for regeneration therapy, but teratoma formation is one of the critical problems safe clinical application. After differentiation, precise detection and subsequent elimination undifferentiated PSC essential teratoma-free cell a practical procedure yet to be developed. CDy1, specific fluorescent probe, was investigated generation reactive oxygen species (ROS) demonstrated induce selective death upon visible light irradiation. Importantly,...
Water proton spin relaxivities, colloidal stability, and biocompatibility of nanoparticle magnetic resonance imaging (MRI) contrast agents depend on surface-coating ligands. In this study, hydrophilic biocompatible polyethylenimines (PEIs) different sizes (Mn = 1200 60,000 amu) were used as ligands for ultrasmall holmium oxide (Ho2O3) nanoparticles. The synthesized PEI1200- PEI60000-coated Ho2O3 nanoparticles, with an average particle diameter 2.05 1.90 nm, respectively, demonstrated low...
Nanoparticles are considered potential candidates for a new class of magnetic resonance imaging (MRI) contrast agents. Negative MRI agents require high moments. However, if nanoparticles can exclusively induce transverse water proton spin relaxation with negligible induction longitudinal relaxation, they may provide negative MR images despite having low moments, thus acting as an efficient T2 agent. In this study, carbon-coated paramagnetic dysprosium oxide (DYO@C) (core = DYO DyxOy; shell...
Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter 2.0 nm were synthesized using one-pot polyol method. The exhibited r1 and r2 19.1 = 53.7 s−1mM−1, respectively, (r1 are longitudinal transverse water–proton spin relaxivities, respectively) at 3.0 T MR...
Hematopoietic injury resulting from the damage of hematopoietic stem/progenitor cells (HSPCs) can be induced by either nuclear accident or radiotherapy. Radiomitigation HSPCs is critical for development medical countermeasure agents. StemRegenin 1 (SR1) modulates maintenance and function under non-stress conditions. However, impact SR1 in radiation-induced both vivo vitro remains unknown. In this study, we found that treatment with after irradiation C57BL/6 mice significantly mitigates...
Classification of foot–ground contact phases, as well the swing phase is essential in biomechanics domains where lower-limb motion analysis required; this used for rehabilitation, walking gait and improvement, exoskeleton capture. In study, sliding-window label overlapping time-series wearable data training dataset acquisition proposed to accurately detect which are composed 3 sub-phases phase, at a frequency 100 Hz with convolutional neural network (CNN) architecture. We not only succeeded...
The aim of this work was to evaluate a tumor-targeting porphyrin-based gadolinium complex (Gd-TDAP) for use as an MR/optical imaging agent and potential therapeutic agent. Gd-TDAP had higher longitudinal relaxivity (11.8 mM–1 s–1) than commercial MRI contrast (Omniscan; 3.7 in HSA solution (0.67 mM) at 3 T. characteristics were confirmed by T1-weighted MR optical using orthotopic brain tumor mouse model, which showed 1.3-fold uptake compared normal tissues. cell fraction data U87MG...
The purpose of this study is to assess the physicochemical properties and MRI diagnostic efficacy two newly synthesized 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-type Gd chelates, Gd-SucL Gd-GluL, with an asymmetric α-substituted pendant arm as potential hepatocyte-specific magnetic resonance imaging contrast agents (MRI CAs). Our findings show that fine conformational changes in chelating affect vivo pharmacokinetic behavior CA, a six-membered substituent more...
The burgeoning interest in developing boron neutron capture therapy (BNCT) tracers and their accompanying diagnostics for the treatment of recalcitrant tumors has prompted this investigation. Our study aims to devise a tumor strategy utilizing BNCT target αvβ3 integrin. To end, we propose pioneering boron-infused cyclic Arg-Gly-Asp (RGD) peptide, cRGD(d-BPA)K, designed as an efficacious tracer. Additionally, introduce its diagnostic complement, DOTA-cRGD(d-BPA)K, tailored positron emission...