A5016807045- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Fungal Infections and Studies
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- T-cell and Retrovirus Studies
- Histone Deacetylase Inhibitors Research
- Antifungal resistance and susceptibility
- Childhood Cancer Survivors' Quality of Life
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Sarcoma Diagnosis and Treatment
Seoul National University
2011-2025
Seoul National University Hospital
2016-2025
Weatherford College
2024
National University College
2017-2023
New Generation University College
2011-2023
Korea Institute of Radiological and Medical Sciences
2006-2023
Keimyung University
2022
Ulsan College
2022
Inje University Busan Paik Hospital
2022
Ulsan University Hospital
2022
The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and pathology acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery significance DNMT3A-destabilizing mutations (DNMT3AINS) in AML, we here investigate common characteristics DNMT3AINS AML methylomes through computational analyses. We present that AMLs are considerably different from those DNMT3AR882 they exhibit increased intratumor DNA methylation...
Significance Understanding the working mechanism of a chemotherapy drug is critical step toward achieving patient-specific treatment strategy. Decitabine an FDA-approved being used to treat myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Here, we employed image-based screening platform investigate downstream factors decitabine. We find that RNA-binding protein Staufen1 (Stau1) required for decitabine-mediated cancer cell death. show Stau1 stabilizes endogenous retrovirus...
// Dok Hyun Yoon 1,* , Seok Jin Kim 2,* Seong Jeong 3 Dong-Yeop Shin 4 Sung Hwa Bae 5 Junshik Hong 6 Kyu Park 7 Ho-Young Yhim 8 Deok-Hwan Yang 9 Hyewon Lee 10 Hye Kang 11 Mark 12 Hyeon-Seok Eom Jae-Yong Kwak Jae Hoon Cheolwon Suh 1 and Won Seog 2 Department of Oncology, Asan Medical Center, University Ulsan College Medicine, Seoul, Korea Samsung Sungkyunkwan School Hematology-Oncology, Ajou Suwon, Internal Seoul National Hospital, Catholic Daegu Daegu, Gachon Gil Incheon,...
Purpose Fibroblast growth factor (FGF) signals are important in carcinogenesis and progression of prostate cancer. Dovitinib is an oral, pan-class inhibitor vascular endothelial receptor (VEGFR), platelet-derived receptor, fibroblast (FGFR). We evaluated the efficacy toxicity dovitinib men with metastatic castration resistant cancer (mCRPC). Materials Methods This study was a single-arm, phase II, open-label, multicenter trial 500 mg/day (5-days-on/2-days-off schedule). The primary endpoint...
Key Points South Korean MPN patients had a significantly higher risk of developing second primary solid tumors than that the general population. Patients with SMF an overall survival comparable to those PMF less SAML.
Abstract Background Vitamin C suppresses leukaemogenesis by modulating Tet methylcytosine dioxygenase (TET) activity. However, its beneficial effect in the treatment of patients with acute myeloid leukaemia (AML) remains controversial. In this study, we aimed to identify a potential predictive biomarker for vitamin AML. Methods Gene expression patterns and their relevance survival AML were analysed The Cancer Genome Atlas (TCGA) Therapeutically Applicable Research Generate Effective...
Oral mucositis (OM) is a common complication of chemotherapy and remains significant unmet need. The aim this study was to investigate the role oral bacteriota HSV-1 in OM. Forty-six patients admitted for autologous hematopoietic stem cell transplantation were longitudinally evaluated OM, Candida, HSV-1, leukocyte count, buccal mucosal bacterial samples obtained during their admission period. communities collected at baseline post-chemotherapy, chosen from time with highest severity,...
This study investigated the prognostic factors of Castleman disease (CD) and focused specifically on multicentric CD (MCD). Seventy patients with were studied. Forty-three (61.5%) had unicentric (UCD) 27 (38.5%) MCD. Thirty-six UCD (83.7%) underwent surgical excision, 25 MCD (92.6%) received systemic treatment, including corticosteroids combination chemotherapy. In MCD, age >60 years presence splenomegaly for progression-free survival (hazard ratio [HR] 9.01, 95% confidence interval [CI]...
Summary We investigated the prognostic value of magnetic resonance imaging ( MRI ) pattern bone marrow involvement in patients with multiple myeloma MM eligible for autologous stem cell transplantation ASCT ). 126 untreated indicated underwent spine and cytogenetic analysis at diagnosis. All received after induction therapy VAD (vincristine, doxorubicin, dexamethasone; n = 55) or a thalidomide‐based regimen TCD ; 71). Thalidomide maintenance was performed 68 patients. The normal 27, focal...
CKD-516 is a newly developed vascular disrupting agent. This phase I dose-escalation study of was conducted to determine maximum-tolerated dose (MTD), safety, pharmacokinetics, and preliminary antitumor efficacy in patients with advanced solid tumors.Patients received intravenously on D1 D8 every 3 weeks, standard 3+3 design. Safety evaluated by National Cancer Institute Common Terminology Criteria for Adverse Events ver. 4.02 response assessed Response Evaluation Solid Tumor...
Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy safety of micafungin during first induction chemotherapy patients with acute leukemia. We also compared outcomes those posaconazole myeloid leukemia (AML).Medically fit newly diagnosed received 50 mg intravenously once daily from initiation to recovery neutrophil count, suspected fungal infection, or unacceptable drug-related toxicity (...
Acute myeloid leukemia (AML) is a type of in adults with high mortality rate and poor prognosis. Although targeted therapeutics, chemotherapy, hematopoietic stem cell transplantation can improve the prognosis, recurrence still high, 5-year survival approximately 40%. This study aimed to develop an IgG-based asymmetric bispecific antibody that targets CLL-1 CD3 for treating AML.ABL602 candidates were compared terms binding activity, T-cell activation, tumor-killing activities. ABL602-mediated...
This study aimed to assess the efficacy of dual T-cell suppression using individually tailored doses antithymocyte globulin (ATG) and attenuated dose post-transplant cyclophosphamide (PTCy) in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). We conducted a retrospective analysis 78 adults with acute leukemia or myelodysplastic syndrome who underwent haplo-HSCT intravenous busulfan fludarabine conditioning. Thirty-two patients received ATG/PTCy, while 46 ATG (7.5 mg/kg) as...